Clinical applications of spectral molecular imaging: potential and challenges.

abstract：:In the pursuit of understanding the pathological alterations that underlie ischaemic injuries, such as vascular remodelling and reorganisation, there is a need for recognising the capabilities and limitations of in vivo imaging techniques. Thus, this review presents contemporary published research of imaging modalitie...

journal_title：Contrast media & molecular imaging

authors： Gandhi R,Tsoumpas C

更新日期：2019-02-03 00:00:00

abstract：:Purpose. To investigate the value of SUV metrics and radiomic features based on the ability of 18F-FDG PET/CT in differentiating between breast lymphoma and breast carcinoma. Methods. A total of 67 breast nodules from 44 patients who underwent 18F-FDG PET/CT pretreatment were retrospectively analyzed. Radiomic paramet...

journal_title：Contrast media & molecular imaging

authors： Ou X,Wang J,Zhou R,Zhu S,Pang F,Zhou Y,Tian R,Ma X

更新日期：2019-02-25 00:00:00

abstract：:Photoacoustic imaging is an emerging imaging modality for noninvasive detection of tissue structural and functional anomalies. Multifunctional microbubbles (MBs) and nanobubbles (NBs) are contrast agents integrating multiple disease-targeting, imaging and therapeutic functions. Multifunctional MBs and NBs represent an...

journal_title：Contrast media & molecular imaging

authors： Xu RX

更新日期：2011-09-01 00:00:00

abstract：:Recent advances in artificial intelligence (AI) and deep learning (DL) have impacted many scientific fields including biomedical maging. Magnetic resonance imaging (MRI) is a well-established method in breast imaging with several indications including screening, staging, and therapy monitoring. The rapid development a...

journal_title：Contrast media & molecular imaging

authors： Meyer-Bäse A,Morra L,Meyer-Bäse U,Pinker K

更新日期：2020-08-28 00:00:00

abstract：Aim:To evaluate reproducibility and stability of radiomic features as effects of the use of different volume segmentation methods and reconstruction settings. The potential of radiomics in really capturing the presence of heterogeneous tumor uptake and irregular shape was also investigated. Materials and Methods:An an...

journal_title：Contrast media & molecular imaging

authors： Gallivanone F,Interlenghi M,D'Ambrosio D,Trifirò G,Castiglioni I

更新日期：2018-09-10 00:00:00

abstract：:Glioblastoma multiforme is the most aggressive form of brain tumor. Early and accurate diagnosis of glioma and its borders is an important step for its successful treatment. One of the promising targets for selective visualization of glioma and its margins is connexin 43 (Cx43), which is highly expressed in reactive a...

journal_title：Contrast media & molecular imaging

authors： Abakumova T,Abakumov M,Shein S,Chelushkin P,Bychkov D,Mukhin V,Yusubalieva G,Grinenko N,Kabanov A,Nukolova N,Chekhonin V

更新日期：2016-01-01 00:00:00

abstract：:A generic site-specific conjugation method that generates a homogeneous product is of utmost importance in tracer development for molecular imaging and therapy. We explored the protein-ligation capacity of the enzyme Sortase A to label camelid single-domain antibody-fragments, also known as nanobodies. The versatility...

journal_title：Contrast media & molecular imaging

authors： Massa S,Vikani N,Betti C,Ballet S,Vanderhaegen S,Steyaert J,Descamps B,Vanhove C,Bunschoten A,van Leeuwen FW,Hernot S,Caveliers V,Lahoutte T,Muyldermans S,Xavier C,Devoogdt N

更新日期：2016-09-01 00:00:00

abstract：:Stem cells, cancer cells and immune cells were labeled by co-incubation with a new ultra-small iron oxide nanoparticle called Molday ION Rhodamine-B (MIRB). Iron staining, fluorescence imaging, transmission electron microscopy and flow cytometry were used to assess cell viability, function and labeling efficiency. Thi...

journal_title：Contrast media & molecular imaging

authors： McFadden C,Mallett CL,Foster PJ

更新日期：2011-11-01 00:00:00

abstract：:The aim of this work was to investigate the MRI findings on tumor xenografts induced in nude mice by the inoculation of human pancreatic cancer cells labeled with superparamagnetic iron oxide (SPIO), and to monitor the kinetics of SPIO distribution in tumor xenografts. The labeled cancer cells were subcutaneously inoc...

journal_title：Contrast media & molecular imaging

authors： Wu CY,Pu Y,Liu G,Shao Y,Ma QS,Zhang XM

更新日期：2012-01-01 00:00:00

abstract：:Generally angiogenic factors induce the expression of E-selectin in vascular endothelial cells in the tumors. In this study, we employed an anti-E-selectin monoclonal antibody to target tumors in vivo and evaluated an optical imaging reagent to visualize tumor regions. The anti-E-selectin antibody was conjugated on th...

journal_title：Contrast media & molecular imaging

authors： Hirai M,Hiramatsu Y,Iwashita S,Otani T,Chen L,Li YG,Okada M,Oie K,Igarashi K,Wakita H,Seno M

更新日期：2010-03-01 00:00:00

abstract：:The development of molecular probes and novel imaging modalities, allowing better resolution and specificity, is associated with an increased potential for molecular imaging of atherosclerotic plaques especially in basic and pre-clinical research applications. In that context, a photoacoustic molecular probe based on ...

journal_title：Contrast media & molecular imaging

authors： Rouleau L,Berti R,Ng VW,Matteau-Pelletier C,Lam T,Saboural P,Kakkar AK,Lesage F,Rhéaume E,Tardif JC

更新日期：2013-01-01 00:00:00

abstract：:Various contrast agents (Magnevist, Gadovist and Multihance) loaded into polymeric nanocapsules were synthesized by the inverse miniemulsion technique. The relaxivity of the resultant contrast agents was assessed at 1.5 T magnetic field strength. The ionic relaxivity of the contrast agents could at least be maintained...

journal_title：Contrast media & molecular imaging

authors： Sharma S,Paiphansiri U,Hombach V,Mailänder V,Zimmermann O,Landfester K,Rasche V

更新日期：2010-03-01 00:00:00

abstract：:Knowledge of the longitudinal and transverse relaxation times (T(1) and T(2)) of water protons in an aqueous solution of an MRI contrast agent is essential for its characterization. These parameters can be measured at low field on low resolution spectrometers or at high field on high resolution spectrometers. The reli...

journal_title：Contrast media & molecular imaging

authors： Henoumont C,Laurent S,Vander Elst L

更新日期：2009-11-01 00:00:00

abstract：Objective:We aimed to propose an automatic method based on Support Vector Machine (SVM) and Dynamic Contrast-Enhanced Magnetic Resonance Imaging (DCE-MRI) to segment the tumor lesions of head and neck cancer (HNC). Materials and Methods:120 DCE-MRI samples were collected. Five curve features and two principal componen...

journal_title：Contrast media & molecular imaging

authors： Deng W,Luo L,Lin X,Fang T,Liu D,Dan G,Chen H

更新日期：2017-09-07 00:00:00

abstract：:Gold nanoparticles coated by gadolinium (III) chelates (Au@DTDTPA) where DTDTPA is a dithiolated bisamide derivative of diethylenetriamine-N,N,N',N'',N''-pentaacetic acid (DTPA), constituted contrast agents for both X-ray computed tomography and magnetic resonance imaging. In an MRI context, highly stable Gd(3+) compl...

journal_title：Contrast media & molecular imaging

authors： Mogilireddy V,Déchamps-Olivier I,Alric C,Laurent G,Laurent S,Vander Elst L,Muller R,Bazzi R,Roux S,Tillement O,Chuburu F

更新日期：2015-05-01 00:00:00

abstract：:Two novel Gd-based contrast agents (CAs) for the molecular imaging of matrix metalloproteinases (MMPs) were synthetized and characterized in vitro and in vivo. These probes were based on the PLG*LWAR peptide sequence, known to be hydrolyzed between Gly and Leu by a broad panel of MMPs. A Gd-DOTA chelate was conjugated...

journal_title：Contrast media & molecular imaging

authors： Gringeri CV,Menchise V,Rizzitelli S,Cittadino E,Catanzaro V,Dati G,Chaabane L,Digilio G,Aime S

更新日期：2012-03-01 00:00:00

abstract：:To date, the combination of histological sectioning, staining, and microscopic assessment of the 2D sections is still the golden standard for structural and compositional analysis of biological tissues. X-ray microfocus computed tomography (microCT) is an emerging 3D imaging technique with high potential for 3D struct...

journal_title：Contrast media & molecular imaging

authors： de Bournonville S,Vangrunderbeeck S,Kerckhofs G

更新日期：2019-02-28 00:00:00

abstract：:A new high-throughput MRI method for screening chemical exchange saturation transfer (CEST) agents is demonstrated, allowing simultaneous testing of multiple samples with minimal attention to sample configuration and shimming of the main magnetic field (B(0)). This approach, which is applicable to diamagnetic, paramag...

journal_title：Contrast media & molecular imaging

authors： Liu G,Gilad AA,Bulte JW,van Zijl PC,McMahon MT

更新日期：2010-05-01 00:00:00

abstract：:Quantum dots (QDs) are fluorescent nanoparticles with broad excitation and narrow, wavelength-tunable emission spectra. They are used extensively for in vitro fluorescence imaging studies and more recently for in vivo small animal and pre-clinical studies. To date there has been little concern about the selection of Q...

journal_title：Contrast media & molecular imaging

authors： Rosenblum LT,Kosaka N,Mitsunaga M,Choyke PL,Kobayashi H

更新日期：2011-05-01 00:00:00

abstract：:The use of superparamagnetic iron oxide (SPIO) for labeling cells holds great promise for clinically applicable cell tracking using magnetic resonance imaging. For clinical application, an effectively and specifically labeled cell preparation is highly desired (i.e. a large amount of intracellular iron and a negligibl...

journal_title：Contrast media & molecular imaging

authors： van Buul GM,Farrell E,Kops N,van Tiel ST,Bos PK,Weinans H,Krestin GP,van Osch GJ,Bernsen MR

更新日期：2009-09-01 00:00:00

abstract：:We evaluated the difference in the status of dopamine transporters (DATs) depending on Parkinsonism, cerebellar, and autonomic features using F-18 FP-CIT positron emission tomography (PET) in multiple system atrophy with cerebellar ataxia (MSA-C). We also assessed whether the DAT PET could be useful in the management ...

journal_title：Contrast media & molecular imaging

authors： Jeong YJ,Cheon SM,Kang DY,Kim JW

更新日期：2017-11-29 00:00:00

abstract：:D-α-Tocopheryl polyethylene glycol 1000 succinate (TPGS) is a Food and Drug Administration (FDA) approved biomaterial that can form nanosized micelles in aqueous solution. TPGS micelles stand as an interesting system to perform drug delivery as they can carry lipophilic drugs and overcome P glycoprotein efflux as well...

journal_title：Contrast media & molecular imaging

authors： Tesan FC,Nicoud MB,Nuñez M,Medina VA,Chiappetta DA,Salgueiro MJ

更新日期：2019-04-23 00:00:00

abstract：Objective:To synthesize 68Ga-Glu-urea-Lys(Ahx)-HBED-CC (68Ga-PSMA-11) with a synthesis module and investigate PET-CT imaging to monitor PSMA expression during prostate cancer (PCa) progression and tumor growth in mice bearing subcutaneous PCa xenografts. Method:The radiochemical purity and stability of  68Ga-PSMA-11 w...

journal_title：Contrast media & molecular imaging

authors： Wang Y,Shao G,Wu J,Cui C,Zang S,Qiu F,Jia R,Wang Z,Wang F

更新日期：2018-04-26 00:00:00

abstract：:The transplantation of pancreatic islets containing β-cells, which produce insulin, is an alternative approach to the treatment of type 1 diabetes mellitus. The non-invasive visualization of transplanted islets can be performed using MRI; however, this requires labeling of the islets with a suitable contrast agent pri...

journal_title：Contrast media & molecular imaging

authors： Herynek V,Berková Z,Dovolilová E,Jirák D,Kříž J,Girman P,Saudek F,Hájek M

更新日期：2011-07-01 00:00:00

abstract：:A novel tumor stroma targeting and membrane-penetrating cyclic peptide, named iCREKA, was designed and labeled by fluorescein isothiocyanate (FITC) and positron emitter 18F to build the tumor-targeting tracers. The FITC-iCREKA was proved to have significantly higher cellular uptake in the glioma U87 cells in the prese...

journal_title：Contrast media & molecular imaging

authors： Wang LJ,Li HS,Wang QS,Wu HB,Han YJ,Zhou WL,Wang M,Huang S

更新日期：2018-03-04 00:00:00

abstract：:Inorganic doping was used to create flexible, paramagnetic nanoparticle contrast agents for in vivo molecular magnetic resonance imaging (MRI) with low transverse relaxivity (r2). Most nanoparticle contrast agents formed from superparamagnetic metal oxides are developed with high r2. While sensitive, they can have lim...

journal_title：Contrast media & molecular imaging

authors： Clavijo Jordan MV,Beeman SC,Baldelomar EJ,Bennett KM

更新日期：2014-09-01 00:00:00

abstract：:Chemical exchange saturation transfer (CEST) MRI is sensitive to dilute proteins and peptides as well as microenvironmental properties. However, the complexity of the CEST MRI effect, which varies with the labile proton content, exchange rate and experimental conditions, underscores the need for developing quantitativ...

journal_title：Contrast media & molecular imaging

authors： Sun PZ,Wang Y,Dai Z,Xiao G,Wu R

更新日期：2014-07-01 00:00:00

abstract：:Perfluorocarbon (PFC) double emulsions loaded with a water-soluble, therapeutic agent can be triggered by ultrasound in a process known as acoustic droplet vaporization. Elucidating the stability and biodistribution of these sonosensitive vehicles and encapsulated agents is critical in developing targeted drug deliver...

journal_title：Contrast media & molecular imaging

authors： Fabiilli ML,Piert MR,Koeppe RA,Sherman PS,Quesada CA,Kripfgans OD

更新日期：2013-07-01 00:00:00

abstract：:Various studies have shown that various cell types can be labeled with iron oxide particles and visualized by magnetic resonance imaging (MRI). However, reported protocols for cell labeling show a large variation in terms of labeling dose and incubation time. It is therefore not clear how different labeling protocols ...

journal_title：Contrast media & molecular imaging

authors： van Tiel ST,Wielopolski PA,Houston GC,Krestin GP,Bernsen MR

更新日期：2010-09-01 00:00:00

abstract：:Magnetic fluid hyperthermia (MFH) with chemically synthesized nanoparticles is currently used in clinical trials as it destroys tumor cells with an extremely localized deposition of thermal energy. In this paper, we investigated an MFH protocol based on magnetic nanoparticles naturally produced by magnetotactic bacter...

journal_title：Contrast media & molecular imaging

authors： Mannucci S,Tambalo S,Conti G,Ghin L,Milanese A,Carboncino A,Nicolato E,Marinozzi MR,Benati D,Bassi R,Marzola P,Sbarbati A

更新日期：2018-07-11 00:00:00