当前位置： SCI文献检索 > Contrast Media & Molecular Imaging期刊下所有文献 > Disruptive chemical doping in a ferritin-based iron oxide nanoparticle to decrease r2 and enhance detection with T1-weighted MRI.

Disruptive chemical doping in a ferritin-based iron oxide nanoparticle to decrease r2 and enhance detection with T1-weighted MRI.

Abstract：

:Inorganic doping was used to create flexible, paramagnetic nanoparticle contrast agents for in vivo molecular magnetic resonance imaging (MRI) with low transverse relaxivity (r2). Most nanoparticle contrast agents formed from superparamagnetic metal oxides are developed with high r2. While sensitive, they can have limited in vivo detection due to a number of constraints with T2 or T2*-weighted imaging. T1-weighted imaging is often preferred for molecular MRI, but most T1-shortening agents are small chelates with low metal payload or are nanoparticles that also shorten T2 and limit the range of concentrations detectable with T1-weighting. Here we used tungsten and iron deposition to form doped iron oxide crystals inside the apoferritin cavity to form a WFe nanoparticle with a disordered crystal and un-coupled atomic magnetic moments. The atomic magnetic moments were thus localized, resulting in a principally paramagnetic nanoparticle. The WFe nanoparticles had no coercivity or saturation magnetization at 5 K and sweeping up to ± 20,000 Oe, while native ferritin had a coercivity of 3000 Oe and saturation at ± 20,000 Oe. This tungsten-iron crystal paramagnetism resulted in an increased WFe particle longitudinal relaxivity (r1) of 4870 mm(-1) s(-1) and a reduced transverse relaxivity (r2) of 9076 mm(-1) s(-1) compared with native ferritin. The accumulation of the particles was detected with T1-weighted MRI in concentrations from 20 to 400 nm in vivo, both injected in the rat brain and targeted to the rat kidney glomerulus. The WFe apoferritin nanoparticles were not cytotoxic up to 700 nm particle concentrations, making them potentially important for targeted molecular MRI.

journal_name

Contrast Media Mol Imaging

journal_title

Contrast media & molecular imaging

authors

Clavijo Jordan MV,Beeman SC,Baldelomar EJ,Bennett KM

doi

10.1002/cmmi.1578

subject

Has Abstract

pub_date

2014-09-01 00:00:00

pages

323-32

issue

5

eissn

1555-4309

issn

1555-4317

journal_volume

9

pub_type

杂志文章

相关文献

Contrast Media & Molecular Imaging文献大全
  • Ferumoxides-protamine sulfate is more effective than ferucarbotran for cell labeling: implications for clinically applicable cell tracking using MRI.

    abstract：:The use of superparamagnetic iron oxide (SPIO) for labeling cells holds great promise for clinically applicable cell tracking using magnetic resonance imaging. For clinical application, an effectively and specifically labeled cell preparation is highly desired (i.e. a large amount of intracellular iron and a negligibl...

    journal_title：Contrast media & molecular imaging

    pub_type： 杂志文章

    doi：10.1002/cmmi.289

    authors： van Buul GM,Farrell E,Kops N,van Tiel ST,Bos PK,Weinans H,Krestin GP,van Osch GJ,Bernsen MR

    更新日期：2009-09-01 00:00:00

  • High-throughput screening of chemical exchange saturation transfer MR contrast agents.

    abstract：:A new high-throughput MRI method for screening chemical exchange saturation transfer (CEST) agents is demonstrated, allowing simultaneous testing of multiple samples with minimal attention to sample configuration and shimming of the main magnetic field (B(0)). This approach, which is applicable to diamagnetic, paramag...

    journal_title：Contrast media & molecular imaging

    pub_type： 杂志文章

    doi：10.1002/cmmi.383

    authors： Liu G,Gilad AA,Bulte JW,van Zijl PC,McMahon MT

    更新日期：2010-05-01 00:00:00

  • Classification of acute and delayed contrast media-induced reactions: proposal of a three-step system.

    abstract：:Physicians and scientists use a broad spectrum of terms to classify contrast media (CM)-induced adverse reactions. In particular, the designation of hypersensitivity reactions is quite varied. Consequently, comparisons of different papers dealing with this subject are difficult or even impossible. Moreover, general de...

    journal_title：Contrast media & molecular imaging

    pub_type： 杂志文章

    doi：10.1002/cmmi.1475

    authors： Böhm I,Heverhagen JT,Klose KJ

    更新日期：2012-11-01 00:00:00

  • Antibody-functionalized nanoparticles for imaging cancer: influence of conjugation to gold nanoparticles on the biodistribution of 89Zr-labeled cetuximab in mice.

    abstract：:Antibody-labeled gold nanoparticles represent a promising novel tool regarding cancer imaging and therapy. Nevertheless, the characterization of biodistribution of such immunonanocarriers has been poorly documented. In this study, the biodistribution of (89)Zr-labeled cetuximab before and after the coupling reaction t...

    journal_title：Contrast media & molecular imaging

    pub_type： 杂志文章

    doi：10.1002/cmmi.1539

    authors： Karmani L,Labar D,Valembois V,Bouchat V,Nagaswaran PG,Bol A,Gillart J,Levêque P,Bouzin C,Bonifazi D,Michiels C,Feron O,Grégoire V,Lucas S,Vander Borght T,Gallez B

    更新日期：2013-09-01 00:00:00

  • Synthesis and in vitro evaluation of MR molecular imaging probes using J591 mAb-conjugated SPIONs for specific detection of prostate cancer.

    abstract：:Carcinoma of the prostate is the most frequent diagnosed malignant tumor in men and is the second leading cause of cancer-related death in this group. The cure rate of prostate cancer is highly dependent on the stage of disease at the diagnosis and early detection is key to designing effective treatment strategies. Th...

    journal_title：Contrast media & molecular imaging

    pub_type： 杂志文章

    doi：10.1002/cmmi.1514

    authors： Abdolahi M,Shahbazi-Gahrouei D,Laurent S,Sermeus C,Firozian F,Allen BJ,Boutry S,Muller RN

    更新日期：2013-03-01 00:00:00

  • The influence of ferucarbotran on the chondrogenesis of human mesenchymal stem cells.

    abstract：:For in vivo applications of magnetically labeled stem cells, biological effects of the labeling procedure have to be precluded. This study evaluates the effect of different ferucarbotran cell labeling protocols on chondrogenic differentiation of human mesenchymal stem cells (hMSC) as well as their implications for MR ...

    journal_title：Contrast media & molecular imaging

    pub_type： 杂志文章

    doi：10.1002/cmmi.276

    authors： Henning TD,Sutton EJ,Kim A,Golovko D,Horvai A,Ackerman L,Sennino B,McDonald D,Lotz J,Daldrup-Link HE

    更新日期：2009-07-01 00:00:00

  • MR imaging of human pancreatic cancer xenograft labeled with superparamagnetic iron oxide in nude mice.

    abstract：:The aim of this work was to investigate the MRI findings on tumor xenografts induced in nude mice by the inoculation of human pancreatic cancer cells labeled with superparamagnetic iron oxide (SPIO), and to monitor the kinetics of SPIO distribution in tumor xenografts. The labeled cancer cells were subcutaneously inoc...

    journal_title：Contrast media & molecular imaging

    pub_type： 杂志文章

    doi：10.1002/cmmi.465

    authors： Wu CY,Pu Y,Liu G,Shao Y,Ma QS,Zhang XM

    更新日期：2012-01-01 00:00:00

  • An imageable retinoid acid derivative to detect human cancer xenografts and study therapeutic dosing to reduce its toxicity.

    abstract：:Developing agents with 'seek, treat and see' capability is critical for personalized molecular medicine. Those agents will specifically target the disease markers for diagnosis and apply the biologically effective dose for treatment. Retinoids regulate a multitude of biological processes. In addition, retinoic acid ca...

    journal_title：Contrast media & molecular imaging

    pub_type： 杂志文章

    doi：10.1002/cmmi.419

    authors： Wang W,Qiu X,Zhang F,Sun J,Cameron AG,Wendt JA,Mawad ME,Ke S

    更新日期：2011-07-01 00:00:00

  • Magnetosomes Extracted from Magnetospirillum gryphiswaldense as Theranostic Agents in an Experimental Model of Glioblastoma.

    abstract：:Magnetic fluid hyperthermia (MFH) with chemically synthesized nanoparticles is currently used in clinical trials as it destroys tumor cells with an extremely localized deposition of thermal energy. In this paper, we investigated an MFH protocol based on magnetic nanoparticles naturally produced by magnetotactic bacter...

    journal_title：Contrast media & molecular imaging

    pub_type： 杂志文章

    doi：10.1155/2018/2198703

    authors： Mannucci S,Tambalo S,Conti G,Ghin L,Milanese A,Carboncino A,Nicolato E,Marinozzi MR,Benati D,Bassi R,Marzola P,Sbarbati A

    更新日期：2018-07-11 00:00:00

  • Diagnostic Performance of PET or PET/CT with Different Radiotracers in Patients with Suspicious Lung Cancer or Pleural Tumours according to Published Meta-Analyses.

    abstract：Purpose:Several meta-analyses have reported data about the diagnostic performance of positron emission tomography or positron emission tomography/computed tomography (PET or PET/CT) with different radiotracers in patients with suspicious lung cancer (LC) or pleural tumours (PT). This review article aims at providing an...

    journal_title：Contrast media & molecular imaging

    pub_type： 杂志文章,评审

    doi：10.1155/2020/5282698

    authors： Lococo F,Muoio B,Chiappetta M,Nachira D,Petracca Ciavarella L,Margaritora S,Treglia G

    更新日期：2020-04-25 00:00:00

  • Increased myocardial wall thickening as index of viability assessment: a preliminary report on delayed contrast MRI.

    abstract：PURPOSE:Regional wall thickening measurement by delayed contrast MRI may assess myocardial viability and functional recovery of ischemic cardiomyopathy. MATERIALS AND METHODS:Delayed contrast MRI data was used in 40 patients with significant coronary artery disease and severe left ventricular dysfunction. Regional wal...

    journal_title：Contrast media & molecular imaging

    pub_type： 杂志文章

    doi：10.1002/cmmi.260

    authors： Sharma R,Katz JK

    更新日期：2009-01-01 00:00:00

  • Hepatic 18F-FDG Uptake Measurements on PET/MR: Impact of Volume of Interest Location on Repeatability.

    abstract：Background:To investigate same day 18F-FDG (Fluorodeoxyglucose) PET (Positron Emission Tomography)/MR (Magnetic Resonance) test-retest repeatability of Standardized Uptake Value measurements normalized for body weight (SUV) and lean body mass (SUL) in different locations in the liver. Methods:This prospective study wa...

    journal_title：Contrast media & molecular imaging

    pub_type： 杂志文章

    doi：10.1155/2017/8639731

    authors： Domachevsky L,Bernstine H,Nidam M,Stein D,Goldberg N,Stern D,Abadi-Korek I,Groshar D

    更新日期：2017-05-30 00:00:00

  • 99mTc-Radiolabeled TPGS Nanomicelles Outperform 99mTc-Sestamibi as Breast Cancer Imaging Agent.

    abstract：:D-α-Tocopheryl polyethylene glycol 1000 succinate (TPGS) is a Food and Drug Administration (FDA) approved biomaterial that can form nanosized micelles in aqueous solution. TPGS micelles stand as an interesting system to perform drug delivery as they can carry lipophilic drugs and overcome P glycoprotein efflux as well...

    journal_title：Contrast media & molecular imaging

    pub_type： 杂志文章

    doi：10.1155/2019/4087895

    authors： Tesan FC,Nicoud MB,Nuñez M,Medina VA,Chiappetta DA,Salgueiro MJ

    更新日期：2019-04-23 00:00:00

  • Effect of anesthesia carrier gas on in vivo circulation times of ultrasound microbubble contrast agents in rats.

    abstract：PURPOSE:Microbubble contrast agents are currently implemented in a variety of both clinical and preclinical ultrasound imaging studies. The therapeutic and diagnostic capabilities of these contrast agents are limited by their short in-vivo lifetimes, and research to lengthen their circulation times is on going. In this...

    journal_title：Contrast media & molecular imaging

    pub_type： 杂志文章

    doi：10.1002/cmmi.414

    authors： Mullin L,Gessner R,Kwan J,Kaya M,Borden MA,Dayton PA

    更新日期：2011-05-01 00:00:00

  • Ability of 18F-FDG PET/CT Radiomic Features to Distinguish Breast Carcinoma from Breast Lymphoma.

    abstract：:Purpose. To investigate the value of SUV metrics and radiomic features based on the ability of 18F-FDG PET/CT in differentiating between breast lymphoma and breast carcinoma. Methods. A total of 67 breast nodules from 44 patients who underwent 18F-FDG PET/CT pretreatment were retrospectively analyzed. Radiomic paramet...

    journal_title：Contrast media & molecular imaging

    pub_type： 杂志文章

    doi：10.1155/2019/4507694

    authors： Ou X,Wang J,Zhou R,Zhu S,Pang F,Zhou Y,Tian R,Ma X

    更新日期：2019-02-25 00:00:00

  • Iron Oxide Nanoradiomaterials: Combining Nanoscale Properties with Radioisotopes for Enhanced Molecular Imaging.

    abstract：:The combination of the size-dependent properties of nanomaterials with radioisotopes is emerging as a novel tool for molecular imaging. There are numerous examples already showing how the controlled synthesis of nanoparticles and the incorporation of a radioisotope in the nanostructure offer new features beyond the si...

    journal_title：Contrast media & molecular imaging

    pub_type： 杂志文章,评审

    doi：10.1155/2017/1549580

    authors： Pellico J,Llop J,Fernández-Barahona I,Bhavesh R,Ruiz-Cabello J,Herranz F

    更新日期：2017-11-21 00:00:00

  • Preclinical Imaging Biomarkers for Postischaemic Neurovascular Remodelling.

    abstract：:In the pursuit of understanding the pathological alterations that underlie ischaemic injuries, such as vascular remodelling and reorganisation, there is a need for recognising the capabilities and limitations of in vivo imaging techniques. Thus, this review presents contemporary published research of imaging modalitie...

    journal_title：Contrast media & molecular imaging

    pub_type： 杂志文章,评审

    doi：10.1155/2019/3128529

    authors： Gandhi R,Tsoumpas C

    更新日期：2019-02-03 00:00:00

  • Early Prediction of Treatment Response of Neuroendocrine Hepatic Metastases after Peptide Receptor Radionuclide Therapy with 90Y-DOTATOC Using Diffusion Weighted and Dynamic Contrast-Enhanced MRI.

    abstract：:The purpose of this study was to determine if parameters derived from diffusion-weighted (DW-) and dynamic contrast-enhanced (DCE-) magnetic resonance imaging (MRI) can help to assess early response to peptide receptor radionuclide therapy (PRRT) with 90Y-DOTATOC in neuroendocrine hepatic metastases (NET-HM). Twenty p...

    journal_title：Contrast media & molecular imaging

    pub_type： 杂志文章

    doi：10.1155/2019/1517208

    authors： Weikert T,Maas OC,Haas T,Klarhöfer M,Bremerich J,Forrer F,Sauter AW,Sommer G

    更新日期：2019-11-11 00:00:00

  • Labeling of multiple cell lines using a new iron oxide agent for cell tracking by MRI.

    abstract：:Stem cells, cancer cells and immune cells were labeled by co-incubation with a new ultra-small iron oxide nanoparticle called Molday ION Rhodamine-B (MIRB). Iron staining, fluorescence imaging, transmission electron microscopy and flow cytometry were used to assess cell viability, function and labeling efficiency. Thi...

    journal_title：Contrast media & molecular imaging

    pub_type： 杂志文章

    doi：10.1002/cmmi.456

    authors： McFadden C,Mallett CL,Foster PJ

    更新日期：2011-11-01 00:00:00

  • Contrast-Enhanced MicroCT for Virtual 3D Anatomical Pathology of Biological Tissues: A Literature Review.

    abstract：:To date, the combination of histological sectioning, staining, and microscopic assessment of the 2D sections is still the golden standard for structural and compositional analysis of biological tissues. X-ray microfocus computed tomography (microCT) is an emerging 3D imaging technique with high potential for 3D struct...

    journal_title：Contrast media & molecular imaging

    pub_type： 杂志文章,评审

    doi：10.1155/2019/8617406

    authors： de Bournonville S,Vangrunderbeeck S,Kerckhofs G

    更新日期：2019-02-28 00:00:00

  • Use of 18F-FDG-PET/CT for Retroperitoneal/Intra-Abdominal Soft Tissue Sarcomas.

    abstract：Rationale:To assess the diagnostic value of 18F-FDG-PET/CT for different retroperitoneal soft tissue sarcomas (STS) and other similar tumors. To analyze the predictive value of 18F-FDG-PET/CT for histological grade and main prognostic factors. Methods:195 patients with 44 different diseases have been included. Relatio...

    journal_title：Contrast media & molecular imaging

    pub_type： 杂志文章

    doi：10.1155/2018/2601281

    authors： Liu DN,Li ZW,Wang HY,Zhao M,Zhao W,Hao CY

    更新日期：2018-07-02 00:00:00

  • Multifunctional microbubbles and nanobubbles for photoacoustic imaging.

    abstract：:Photoacoustic imaging is an emerging imaging modality for noninvasive detection of tissue structural and functional anomalies. Multifunctional microbubbles (MBs) and nanobubbles (NBs) are contrast agents integrating multiple disease-targeting, imaging and therapeutic functions. Multifunctional MBs and NBs represent an...

    journal_title：Contrast media & molecular imaging

    pub_type： 杂志文章,评审

    doi：10.1002/cmmi.442

    authors： Xu RX

    更新日期：2011-09-01 00:00:00

  • A First Report on [18F]FPRGD2 PET/CT Imaging in Multiple Myeloma.

    abstract：:An observational study was set up to assess the feasibility of [18F]FPRGD2 PET/CT for imaging patients with multiple myeloma (MM) and to compare its detection rate with low dose CT alone and combined [18F]NaF/[18F]FDG PET/CT images. Four patients (2 newly diagnosed patients and 2 with relapsed MM) were included and un...

    journal_title：Contrast media & molecular imaging

    pub_type： 杂志文章

    doi：10.1155/2017/6162845

    authors： Withofs N,Cousin F,De Prijck B,Bonnet C,Hustinx R,Gambhir SS,Beguin Y,Caers J

    更新日期：2017-07-27 00:00:00

  • Sortase A-mediated site-specific labeling of camelid single-domain antibody-fragments: a versatile strategy for multiple molecular imaging modalities.

    abstract：:A generic site-specific conjugation method that generates a homogeneous product is of utmost importance in tracer development for molecular imaging and therapy. We explored the protein-ligation capacity of the enzyme Sortase A to label camelid single-domain antibody-fragments, also known as nanobodies. The versatility...

    journal_title：Contrast media & molecular imaging

    pub_type： 杂志文章

    doi：10.1002/cmmi.1696

    authors： Massa S,Vikani N,Betti C,Ballet S,Vanderhaegen S,Steyaert J,Descamps B,Vanhove C,Bunschoten A,van Leeuwen FW,Hernot S,Caveliers V,Lahoutte T,Muyldermans S,Xavier C,Devoogdt N

    更新日期：2016-09-01 00:00:00

  • Electron paramagnetic resonance as a sensitive tool to assess the iron oxide content in cells for MRI cell labeling studies.

    abstract：:MRI cell tracking is a promising technique to track various cell types (stem cells, tumor cells, etc.) in living animals. Usually, cells are incubated with iron oxides (T(2) contrast agent) in order to take up the particles before being injected in vivo. Iron oxide quantification is important in such studies for valid...

    journal_title：Contrast media & molecular imaging

    pub_type： 杂志文章

    doi：10.1002/cmmi.497

    authors： Danhier P,De Preter G,Boutry S,Mahieu I,Leveque P,Magat J,Haufroid V,Sonveaux P,Bouzin C,Feron O,Muller RN,Jordan BF,Gallez B

    更新日期：2012-05-01 00:00:00

  • E-selectin targeting to visualize tumors in vivo.

    abstract：:Generally angiogenic factors induce the expression of E-selectin in vascular endothelial cells in the tumors. In this study, we employed an anti-E-selectin monoclonal antibody to target tumors in vivo and evaluated an optical imaging reagent to visualize tumor regions. The anti-E-selectin antibody was conjugated on th...

    journal_title：Contrast media & molecular imaging

    pub_type： 杂志文章

    doi：10.1002/cmmi.367

    authors： Hirai M,Hiramatsu Y,Iwashita S,Otani T,Chen L,Li YG,Okada M,Oie K,Igarashi K,Wakita H,Seno M

    更新日期：2010-03-01 00:00:00

  • Clinical and Prognostic Value of PET/CT Imaging with Combination of 68Ga-DOTATATE and 18F-FDG in Gastroenteropancreatic Neuroendocrine Neoplasms.

    abstract：Background:To evaluate the clinical and prognostic value of PET/CT with combination of 68Ga-DOTATATE and 18F-FDG in gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs). Method:83 patients of GEP-NENs who underwent 68Ga-DOTATATE and 18F-FDG PET/CT were enrolled between June 2013 and December 2016. Well-different...

    journal_title：Contrast media & molecular imaging

    pub_type： 杂志文章

    doi：10.1155/2018/2340389

    authors： Zhang P,Yu J,Li J,Shen L,Li N,Zhu H,Zhai S,Zhang Y,Yang Z,Lu M

    更新日期：2018-02-26 00:00:00

  • VCAM-1-targeting gold nanoshell probe for photoacoustic imaging of atherosclerotic plaque in mice.

    abstract：:The development of molecular probes and novel imaging modalities, allowing better resolution and specificity, is associated with an increased potential for molecular imaging of atherosclerotic plaques especially in basic and pre-clinical research applications. In that context, a photoacoustic molecular probe based on ...

    journal_title：Contrast media & molecular imaging

    pub_type： 杂志文章

    doi：10.1002/cmmi.1491

    authors： Rouleau L,Berti R,Ng VW,Matteau-Pelletier C,Lam T,Saboural P,Kakkar AK,Lesage F,Rhéaume E,Tardif JC

    更新日期：2013-01-01 00:00:00

  • Functionalization of Gadolinium Chelates Silica Nanoparticle through Silane Chemistry for Simultaneous MRI/64Cu PET Imaging.

    abstract：:Multimodal nanoprobes are highly demanded for biomedical imaging applications to enhance the reliability of the diagnostic results. Among different types of nano-objects, ultrasmall silica gadolinium nanoparticle (SiGdNP) appears as a safe, effective, and versatile platform for this purpose. In this study, a new metho...

    journal_title：Contrast media & molecular imaging

    pub_type： 杂志文章

    doi：10.1155/2018/7938267

    authors： Tran VL,Thakare V,Natuzzi M,Moreau M,Oudot A,Vrigneaud JM,Courteau A,Louis C,Roux S,Boschetti F,Denat F,Tillement O,Lux F

    更新日期：2018-11-01 00:00:00

  • Comparison of 68Ga-DOTA-Siglec-9 and 18F-Fluorodeoxyribose-Siglec-9: Inflammation Imaging and Radiation Dosimetry.

    abstract：:Sialic acid-binding immunoglobulin-like lectin 9 (Siglec-9) is a ligand of inflammation-inducible vascular adhesion protein-1 (VAP-1). We compared 68Ga-DOTA- and 18F-fluorodeoxyribose- (FDR-) labeled Siglec-9 motif peptides for PET imaging of inflammation. Methods. Firstly, we examined 68Ga-DOTA-Siglec-9 and 18F-FDR-S...

    journal_title：Contrast media & molecular imaging

    pub_type： 杂志文章

    doi：10.1155/2017/7645070

    authors： Virtanen H,Silvola JMU,Autio A,Li XG,Liljenbäck H,Hellberg S,Siitonen R,Ståhle M,Käkelä M,Airaksinen AJ,Helariutta K,Tolvanen T,Veres TZ,Saraste A,Knuuti J,Jalkanen S,Roivainen A

    更新日期：2017-12-31 00:00:00