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The ratio of human X chromosome to autosome diversity is positively correlated with genetic distance from genes.

Abstract：

:The ratio of X-linked to autosomal diversity was estimated from an analysis of six human genome sequences and found to deviate from the expected value of 0.75. However, the direction of this deviation depends on whether a particular sequence is close to or far from the nearest gene. This pattern may be explained by stronger locally acting selection on X-linked genes compared with autosomal genes, combined with larger effective population sizes for females than for males.

journal_name

Nat Genet

journal_title

Nature genetics

authors

Hammer MF,Woerner AE,Mendez FL,Watkins JC,Cox MP,Wall JD

doi

10.1038/ng.651

subject

Has Abstract

pub_date

2010-10-01 00:00:00

pages

830-1

issue

10

eissn

1061-4036

issn

1546-1718

pii

ng.651

journal_volume

42

pub_type

杂志文章

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