Abstract:
:We report on whole-exome sequencing (WES) of 213 melanomas. Our analysis established NF1, encoding a negative regulator of RAS, as the third most frequently mutated gene in melanoma, after BRAF and NRAS. Inactivating NF1 mutations were present in 46% of melanomas expressing wild-type BRAF and RAS, occurred in older patients and showed a distinct pattern of co-mutation with other RASopathy genes, particularly RASA2. Functional studies showed that NF1 suppression led to increased RAS activation in most, but not all, melanoma cases. In addition, loss of NF1 did not predict sensitivity to MEK or ERK inhibitors. The rebound pathway, as seen by the induction of phosphorylated MEK, occurred in cells both sensitive and resistant to the studied drugs. We conclude that NF1 is a key tumor suppressor lost in melanomas, and that concurrent RASopathy gene mutations may enhance its role in melanomagenesis.
journal_name
Nat Genetjournal_title
Nature geneticsauthors
Krauthammer M,Kong Y,Bacchiocchi A,Evans P,Pornputtapong N,Wu C,McCusker JP,Ma S,Cheng E,Straub R,Serin M,Bosenberg M,Ariyan S,Narayan D,Sznol M,Kluger HM,Mane S,Schlessinger J,Lifton RP,Halaban Rdoi
10.1038/ng.3361subject
Has Abstractpub_date
2015-09-01 00:00:00pages
996-1002issue
9eissn
1061-4036issn
1546-1718pii
ng.3361journal_volume
47pub_type
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