当前位置： SCI文献检索 > NATURE GENETICS期刊下所有文献 > A detrimental mitochondrial-nuclear interaction causes cytoplasmic male sterility in rice.

A detrimental mitochondrial-nuclear interaction causes cytoplasmic male sterility in rice.

Abstract：

:Plant cytoplasmic male sterility (CMS) results from incompatibilities between the organellar and nuclear genomes and prevents self pollination, enabling hybrid crop breeding to increase yields. The Wild Abortive CMS (CMS-WA) has been exploited in the majority of 'three-line' hybrid rice production since the 1970s, but the molecular basis of this trait remains unknown. Here we report that a new mitochondrial gene, WA352, which originated recently in wild rice, confers CMS-WA because the protein it encodes interacts with the nuclear-encoded mitochondrial protein COX11. In CMS-WA lines, WA352 accumulates preferentially in the anther tapetum, thereby inhibiting COX11 function in peroxide metabolism and triggering premature tapetal programmed cell death and consequent pollen abortion. WA352-induced sterility can be suppressed by two restorer-of-fertility (Rf) genes, suggesting the existence of different mechanisms to counteract deleterious cytoplasmic factors. Thus, CMS-related cytoplasmic-nuclear incompatibility is driven by a detrimental interaction between a newly evolved mitochondrial gene and a conserved, essential nuclear gene.

journal_name

Nat Genet

journal_title

Nature genetics

authors

Luo D,Xu H,Liu Z,Guo J,Li H,Chen L,Fang C,Zhang Q,Bai M,Yao N,Wu H,Wu H,Ji C,Zheng H,Chen Y,Ye S,Li X,Zhao X,Li R,Liu YG

doi

10.1038/ng.2570

subject

Has Abstract

pub_date

2013-05-01 00:00:00

pages

573-7

issue

5

eissn

1061-4036

issn

1546-1718

pii

ng.2570

journal_volume

45

pub_type

杂志文章

相关文献

NATURE GENETICS文献大全
  • DNA methylation dynamics during B cell maturation underlie a continuum of disease phenotypes in chronic lymphocytic leukemia.

    abstract：:Charting differences between tumors and normal tissue is a mainstay of cancer research. However, clonal tumor expansion from complex normal tissue architectures potentially obscures cancer-specific events, including divergent epigenetic patterns. Using whole-genome bisulfite sequencing of normal B cell subsets, we obs...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng.3488

    authors： Oakes CC,Seifert M,Assenov Y,Gu L,Przekopowitz M,Ruppert AS,Wang Q,Imbusch CD,Serva A,Koser SD,Brocks D,Lipka DB,Bogatyrova O,Weichenhan D,Brors B,Rassenti L,Kipps TJ,Mertens D,Zapatka M,Lichter P,Döhner H,Küppe

    更新日期：2016-03-01 00:00:00

  • Genome-wide association study identifies a susceptibility locus at 21q21 for ventricular fibrillation in acute myocardial infarction.

    abstract：:Sudden cardiac death from ventricular fibrillation during acute myocardial infarction is a leading cause of total and cardiovascular mortality. To our knowledge, we here report the first genome-wide association study for this trait, conducted in a set of 972 individuals with a first acute myocardial infarction, 515 of...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng.623

    authors： Bezzina CR,Pazoki R,Bardai A,Marsman RF,de Jong JSSG,Blom MT,Scicluna BP,Jukema JW,Bindraban NR,Lichtner P,Pfeufer A,Bishopric NH,Roden DM,Meitinger T,Chugh SS,Myerburg RJ,Jouven X,Kääb S,Dekker LRC,Tan HL,Tanck M

    更新日期：2010-08-01 00:00:00

  • Soundbites.

    abstract：:Dentinogenesis imperfecta (DGI) is characterized by discolored teeth with an opalescent sheen and dentin that fails to support enamel, causing it to easily chip. Two new studies show that DGI is associated with mutations in DSPP, a gene encoding dentin sialophosphoprotein that is processed into two proteins: dentin si...

    journal_title：Nature genetics

    pub_type： 评论,杂志文章

    doi：10.1038/84728

    authors： Patel P

    更新日期：2001-02-01 00:00:00

  • Epilepsy and brain abnormalities in mice lacking the Otx1 gene.

    abstract：:The morphogenesis of the brain and the differentiation of the neural structures are highly complex processes. A series of temporally and spatially regulated morphogenetic events gives rise to smaller areas that are phylogenetically, functionally and often morphogenetically different. Candidate genes for positional inf...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng1096-218

    authors： Acampora D,Mazan S,Avantaggiato V,Barone P,Tuorto F,Lallemand Y,Brûlet P,Simeone A

    更新日期：1996-10-01 00:00:00

  • The roles of MAD1, MAD2 and MAD3 in meiotic progression and the segregation of nonexchange chromosomes.

    abstract：:Errors in meiotic chromosome segregation are the leading cause of spontaneous abortions and birth defects. In humans, chromosomes that fail to experience crossovers (or exchanges) are error-prone, more likely than exchange chromosomes to mis-segregate in meiosis. We used a yeast model to investigate the mechanisms tha...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng1588

    authors： Cheslock PS,Kemp BJ,Boumil RM,Dawson DS

    更新日期：2005-07-01 00:00:00

  • Mutations in CAV3 cause mechanical hyperirritability of skeletal muscle in rippling muscle disease.

    abstract：:Hereditary rippling muscle disease (RMD) is an autosomal dominant human disorder characterized by mechanically triggered contractions of skeletal muscle. Genome-wide linkage analysis has identified an RMD locus on chromosome 3p25. We found missense mutations in positional candidate CAV3 (encoding caveolin 3; ref. 5) i...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/90050

    authors： Betz RC,Schoser BG,Kasper D,Ricker K,Ramírez A,Stein V,Torbergsen T,Lee YA,Nöthen MM,Wienker TF,Malin JP,Propping P,Reis A,Mortier W,Jentsch TJ,Vorgerd M,Kubisch C

    更新日期：2001-07-01 00:00:00

  • A single natural nucleotide mutation alters bacterial pathogen host tropism.

    abstract：:The capacity of microbial pathogens to alter their host tropism leading to epidemics in distinct host species populations is a global public and veterinary health concern. To investigate the molecular basis of a bacterial host-switching event in a tractable host species, we traced the evolutionary trajectory of the co...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng.3219

    authors： Viana D,Comos M,McAdam PR,Ward MJ,Selva L,Guinane CM,González-Muñoz BM,Tristan A,Foster SJ,Fitzgerald JR,Penadés JR

    更新日期：2015-04-01 00:00:00

  • The apolipoprotein(a) gene is regulated by sex hormones and acute-phase inducers in YAC transgenic mice.

    abstract：:High plasma concentrations of apolipoprotein (a) (apo(a)) have been implicated as a major independent risk factor for atherosclerosis in humans. Apo(a) is a large, evolutionarily new gene (present primarily in primates) for which considerable controversy exists concerning the factors that regulate its expression. To i...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng0495-424

    authors： Frazer KA,Narla G,Zhang JL,Rubin EM

    更新日期：1995-04-01 00:00:00

  • The deoxyguanosine kinase gene is mutated in individuals with depleted hepatocerebral mitochondrial DNA.

    abstract：:Mitochondrial DNA (mtDNA)-depletion syndromes (MDS; OMIM 251880) are phenotypically heterogeneous, autosomal-recessive disorders characterized by tissue-specific reduction in mtDNA copy number. Affected individuals with the hepatocerebral form of MDS have early progressive liver failure and neurological abnormalities,...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng746

    authors： Mandel H,Szargel R,Labay V,Elpeleg O,Saada A,Shalata A,Anbinder Y,Berkowitz D,Hartman C,Barak M,Eriksson S,Cohen N

    更新日期：2001-11-01 00:00:00

  • Cohesin promotes stochastic domain intermingling to ensure proper regulation of boundary-proximal genes.

    abstract：:The human genome can be segmented into topologically associating domains (TADs), which have been proposed to spatially sequester genes and regulatory elements through chromatin looping. Interactions between TADs have also been suggested, presumably because of variable boundary positions across individual cells. Howeve...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/s41588-020-0647-9

    authors： Luppino JM,Park DS,Nguyen SC,Lan Y,Xu Z,Yunker R,Joyce EF

    更新日期：2020-08-01 00:00:00

  • Author Correction: The copy number variation landscape of congenital anomalies of the kidney and urinary tract.

    abstract：:In the version of this article initially published, affiliation 38 incorrectly read "ICNU-Nephrology and Urology Department, Barcelona, Spain"; "Renal Division, Hospital Clinic, IDIBAPS, University of Barcelona, Barcelona, Spain" is the correct affiliation. The error has been corrected in the HTML and PDF versions of ...

    journal_title：Nature genetics

    pub_type： 杂志文章,已发布勘误

    doi：10.1038/s41588-019-0376-0

    authors： Verbitsky M,Westland R,Perez A,Kiryluk K,Liu Q,Krithivasan P,Mitrotti A,Fasel DA,Batourina E,Sampson MG,Bodria M,Werth M,Kao C,Martino J,Capone VP,Vivante A,Shril S,Kil BH,Marasa M,Zhang JY,Na YJ,Lim TY,Ahram

    更新日期：2019-04-01 00:00:00

  • A genome-wide association study identifies new susceptibility loci for esophageal adenocarcinoma and Barrett's esophagus.

    abstract：:Esophageal adenocarcinoma is a cancer with rising incidence and poor survival. Most such cancers arise in a specialized intestinal metaplastic epithelium, which is diagnostic of Barrett's esophagus. In a genome-wide association study, we compared esophageal adenocarcinoma cases (n = 2,390) and individuals with precanc...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng.2796

    authors： Levine DM,Ek WE,Zhang R,Liu X,Onstad L,Sather C,Lao-Sirieix P,Gammon MD,Corley DA,Shaheen NJ,Bird NC,Hardie LJ,Murray LJ,Reid BJ,Chow WH,Risch HA,Nyrén O,Ye W,Liu G,Romero Y,Bernstein L,Wu AH,Casson AG,Chano

    更新日期：2013-12-01 00:00:00

  • Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes.

    abstract：:Type 1 diabetes (T1D) is a common autoimmune disorder that arises from the action of multiple genetic and environmental risk factors. We report the findings of a genome-wide association study of T1D, combined in a meta-analysis with two previously published studies. The total sample set included 7,514 cases and 9,045 ...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng.381

    authors： Barrett JC,Clayton DG,Concannon P,Akolkar B,Cooper JD,Erlich HA,Julier C,Morahan G,Nerup J,Nierras C,Plagnol V,Pociot F,Schuilenburg H,Smyth DJ,Stevens H,Todd JA,Walker NM,Rich SS,Type 1 Diabetes Genetics Consortium.

    更新日期：2009-06-01 00:00:00

  • Distinct interactions of PML-RARalpha and PLZF-RARalpha with co-repressors determine differential responses to RA in APL.

    abstract：:Acute promyelocytic leukaemia (APL), associated with chromosomal translocations involving the retinoic acid receptor alpha gene (RARA) and the PML gene, is sensitive to retinoic acid (RA) treatment, while APL patients harbouring translocations between RARA and the PLZF gene do not respond to RA. We have generated PML-...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng0298-126

    authors： He LZ,Guidez F,Tribioli C,Peruzzi D,Ruthardt M,Zelent A,Pandolfi PP

    更新日期：1998-02-01 00:00:00

  • Mutations in the SHANK2 synaptic scaffolding gene in autism spectrum disorder and mental retardation.

    abstract：:Using microarrays, we identified de novo copy number variations in the SHANK2 synaptic scaffolding gene in two unrelated individuals with autism-spectrum disorder (ASD) and mental retardation. DNA sequencing of SHANK2 in 396 individuals with ASD, 184 individuals with mental retardation and 659 unaffected individuals (...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng.589

    authors： Berkel S,Marshall CR,Weiss B,Howe J,Roeth R,Moog U,Endris V,Roberts W,Szatmari P,Pinto D,Bonin M,Riess A,Engels H,Sprengel R,Scherer SW,Rappold GA

    更新日期：2010-06-01 00:00:00

  • Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.

    abstract：:To further understanding of the genetic basis of type 2 diabetes (T2D) susceptibility, we aggregated published meta-analyses of genome-wide association studies (GWAS), including 26,488 cases and 83,964 controls of European, east Asian, south Asian and Mexican and Mexican American ancestry. We observed a significant ex...

    journal_title：Nature genetics

    pub_type： 杂志文章,meta分析

    doi：10.1038/ng.2897

    authors： DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) Consortium.,Asian Genetic Epidemiology Network Type 2 Diabetes (AGEN-T2D) Consortium.,South Asian Type 2 Diabetes (SAT2D) Consortium.,Mexican American Type 2 Diabetes (MAT2D) Consortium.,

    更新日期：2014-03-01 00:00:00

  • Transposon mutagenesis identifies genetic drivers of Braf(V600E) melanoma.

    abstract：:Although nearly half of human melanomas harbor oncogenic BRAF(V600E) mutations, the genetic events that cooperate with these mutations to drive melanogenesis are still largely unknown. Here we show that Sleeping Beauty (SB) transposon-mediated mutagenesis drives melanoma progression in Braf(V600E) mutant mice and iden...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng.3275

    authors： Mann MB,Black MA,Jones DJ,Ward JM,Yew CC,Newberg JY,Dupuy AJ,Rust AG,Bosenberg MW,McMahon M,Print CG,Copeland NG,Jenkins NA

    更新日期：2015-05-01 00:00:00

  • Ocular retardation mouse caused by Chx10 homeobox null allele: impaired retinal progenitor proliferation and bipolar cell differentiation.

    abstract：:Ocular retardation (or) is a murine eye mutation causing microphthalmia, a thin hypocellular retina and optic nerve aplasia. Here we show that mice carrying the OrJ allele have a premature stop codon in the homeobox of the Chx10 gene, a gene expressed at high levels in uncommitted retinal progenitor cells and mature b...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng0496-376

    authors： Burmeister M,Novak J,Liang MY,Basu S,Ploder L,Hawes NL,Vidgen D,Hoover F,Goldman D,Kalnins VI,Roderick TH,Taylor BA,Hankin MH,McInnes RR

    更新日期：1996-04-01 00:00:00

  • Triplication of a 21q22 region contributes to B cell transformation through HMGN1 overexpression and loss of histone H3 Lys27 trimethylation.

    abstract：:Down syndrome confers a 20-fold increased risk of B cell acute lymphoblastic leukemia (B-ALL), and polysomy 21 is the most frequent somatic aneuploidy among all B-ALLs. Yet the mechanistic links between chromosome 21 triplication and B-ALL remain undefined. Here we show that germline triplication of only 31 genes orth...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng.2949

    authors： Lane AA,Chapuy B,Lin CY,Tivey T,Li H,Townsend EC,van Bodegom D,Day TA,Wu SC,Liu H,Yoda A,Alexe G,Schinzel AC,Sullivan TJ,Malinge S,Taylor JE,Stegmaier K,Jaffe JD,Bustin M,te Kronnie G,Izraeli S,Harris MH,Steve

    更新日期：2014-06-01 00:00:00

  • Localization to Xq27 of a susceptibility gene for testicular germ-cell tumours.

    abstract：:Testicular germ-cell tumours (TGCT) affect 1 in 500 men and are the most common cancer in males aged 15-40 in Western European populations. The incidence of TGCT has risen dramatically over the last century. Known risk factors for TGCT include a history of undescended testis (UDT), testicular dysgenesis, infertility, ...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/72877

    authors： Rapley EA,Crockford GP,Teare D,Biggs P,Seal S,Barfoot R,Edwards S,Hamoudi R,Heimdal K,Fossâ SD,Tucker K,Donald J,Collins F,Friedlander M,Hogg D,Goss P,Heidenreich A,Ormiston W,Daly PA,Forman D,Oliver TD,Leahy M

    更新日期：2000-02-01 00:00:00

  • Genome screening by searching for shared segments: mapping a gene for benign recurrent intrahepatic cholestasis.

    abstract：:It is now feasible to map disease genes by screening the genome for linkage disequilibrium between the disease and marker alleles. This report presents the first application of this approach for a previously unmapped locus. A gene for benign recurrent intrahepatic cholestasis (BRIC) was mapped to chromosome 18 by sear...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng1294-380

    authors： Houwen RH,Baharloo S,Blankenship K,Raeymaekers P,Juyn J,Sandkuijl LA,Freimer NB

    更新日期：1994-12-01 00:00:00

  • A genetics-led approach defines the drug target landscape of 30 immune-related traits.

    abstract：:Most candidate drugs currently fail later-stage clinical trials, largely due to poor prediction of efficacy on early target selection1. Drug targets with genetic support are more likely to be therapeutically valid2,3, but the translational use of genome-scale data such as from genome-wide association studies for drug ...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/s41588-019-0456-1

    authors： Fang H,ULTRA-DD Consortium.,De Wolf H,Knezevic B,Burnham KL,Osgood J,Sanniti A,Lledó Lara A,Kasela S,De Cesco S,Wegner JK,Handunnetthi L,McCann FE,Chen L,Sekine T,Brennan PE,Marsden BD,Damerell D,O'Callaghan CA,Boun

    更新日期：2019-07-01 00:00:00

  • Disruption of dog-1 in Caenorhabditis elegans triggers deletions upstream of guanine-rich DNA.

    abstract：:Genetic integrity is crucial to normal cell function, and mutations in genes required for DNA replication and repair underlie various forms of genetic instability and disease, including cancer. One structural feature of intact genomes is runs of homopolymeric dC/dG. Here we describe an unusual mutator phenotype in Cae...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng928

    authors： Cheung I,Schertzer M,Rose A,Lansdorp PM

    更新日期：2002-08-01 00:00:00

  • Integrated human genome-wide maps constructed using the CEPH reference panel.

    abstract：:High resolution linkage maps have proven to be invaluable tools in genetic investigations. We have assembled a collection of genetic maps constructed from primary data collected from investigators performing genotyping using the Centre Etude Polymorphism Humain (CEPH) reference pedigree panel. These maps were construc...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng0494-391

    authors： Buetow KH,Weber JL,Ludwigsen S,Scherpbier-Heddema T,Duyk GM,Sheffield VC,Wang Z,Murray JC

    更新日期：1994-04-01 00:00:00

  • An oncogenic MYB feedback loop drives alternate cell fates in adenoid cystic carcinoma.

    abstract：:Translocation events are frequent in cancer and may create chimeric fusions or 'regulatory rearrangements' that drive oncogene overexpression. Here we identify super-enhancer translocations that drive overexpression of the oncogenic transcription factor MYB as a recurrent theme in adenoid cystic carcinoma (ACC). Whole...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng.3502

    authors： Drier Y,Cotton MJ,Williamson KE,Gillespie SM,Ryan RJ,Kluk MJ,Carey CD,Rodig SJ,Sholl LM,Afrogheh AH,Faquin WC,Queimado L,Qi J,Wick MJ,El-Naggar AK,Bradner JE,Moskaluk CA,Aster JC,Knoechel B,Bernstein BE

    更新日期：2016-03-01 00:00:00

  • Structural forms of the human amylase locus and their relationships to SNPs, haplotypes and obesity.

    abstract：:Hundreds of genes reside in structurally complex, poorly understood regions of the human genome. One such region contains the three amylase genes (AMY2B, AMY2A and AMY1) responsible for digesting starch into sugar. Copy number of AMY1 is reported to be the largest genomic influence on obesity, although genome-wide ass...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng.3340

    authors： Usher CL,Handsaker RE,Esko T,Tuke MA,Weedon MN,Hastie AR,Cao H,Moon JE,Kashin S,Fuchsberger C,Metspalu A,Pato CN,Pato MT,McCarthy MI,Boehnke M,Altshuler DM,Frayling TM,Hirschhorn JN,McCarroll SA

    更新日期：2015-08-01 00:00:00

  • Mutations in SDHC cause autosomal dominant paraganglioma, type 3.

    abstract：:Nonchromaffin paragangliomas (PGLs) are usually benign, neural-crest-derived, slow-growing tumours of parasympathetic ganglia. Between 10% and 50% of cases are familial and are transmitted as autosomal dominant traits with incomplete and age-dependent penetrance. ...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/81551

    authors： Niemann S,Müller U

    更新日期：2000-11-01 00:00:00

  • Glycine receptor beta-subunit gene mutation in spastic mouse associated with LINE-1 element insertion.

    abstract：:Congenital myoclonus is a widespread neurologic disorder characterized by hyperexcitability, muscular spasticity and myoclonus associated with marked reduction in neural glycine binding sites. The recessive mouse mutation spastic (spa) is a prototype of inherited myoclonus. Here we show that defects in the gene encodi...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng0694-136

    authors： Kingsmore SF,Giros B,Suh D,Bieniarz M,Caron MG,Seldin MF

    更新日期：1994-06-01 00:00:00

  • SMARCB1 is required for widespread BAF complex-mediated activation of enhancers and bivalent promoters.

    abstract：:Perturbations to mammalian SWI/SNF (mSWI/SNF or BAF) complexes contribute to more than 20% of human cancers, with driving roles first identified in malignant rhabdoid tumor, an aggressive pediatric cancer characterized by biallelic inactivation of the core BAF complex subunit SMARCB1 (BAF47). However, the mechanism by...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng.3958

    authors： Nakayama RT,Pulice JL,Valencia AM,McBride MJ,McKenzie ZM,Gillespie MA,Ku WL,Teng M,Cui K,Williams RT,Cassel SH,Qing H,Widmer CJ,Demetri GD,Irizarry RA,Zhao K,Ranish JA,Kadoch C

    更新日期：2017-11-01 00:00:00

  • Identification of a novel X-linked gene responsible for Emery-Dreifuss muscular dystrophy.

    abstract：:Emery-Dreifuss muscular dystrophy (EDMD) is an X-linked recessive disorder characterized by slowly progressing contractures, wasting of skeletal muscle and cardiomyopathy. Heart block is a frequent cause of death. The disease gene has been mapped to distal Xq28. Among many genes in this region, we selected eight trans...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng1294-323

    authors： Bione S,Maestrini E,Rivella S,Mancini M,Regis S,Romeo G,Toniolo D

    更新日期：1994-12-01 00:00:00