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Quantitative trait locus analysis of contextual fear conditioning in mice.

Abstract：

:Family, twin and adoption studies provide evidence for a substantial genetic component underlying individual differences in general intelligence, specific cognitive abilities and susceptibility to psychopathologies related to fear-inducing events. Contextual fear conditioning, which is highly conserved across species, can serve as a model for elucidating genes that regulate individual differences in learning and emotion. In fear conditioning, an initially neutral stimulus, such as a tone or a particular environment (context), elicits a fear response after it has been paired with an aversive stimulus, such as shock. Two neural circuits have been implicated in fear conditioning. The fear component is regulated by amygdaloid pathways, while the contextual component is, at least in part, dependent on the hippocampus. C57BL/6J (B6) and DBA/2J (D2) mice differ in several types of complex learning. including contextual fear conditioning. A quantitative trait locus (QTL) analysis of contextual fear conditioning was performed in a B6/D2 F2 intercross population. Two QTLs for contextual conditioning (lod score > 4.3) were identified on chromosomes 10 and 16. QTLs for conditioning to the auditory cue (lod score > 4.3) were localized to chromosomes 1 and 10. Suggestive QTLs (lod score = 2.8-4.1) for contextual conditioning were detected on chromosomes 1, 2 and 3.

journal_name

Nat Genet

journal_title

Nature genetics

authors

Wehner JM,Radcliffe RA,Rosmann ST,Christensen SC,Rasmussen DL,Fulker DW,Wiles M

doi

10.1038/ng1197-331

subject

Has Abstract

pub_date

1997-11-01 00:00:00

pages

331-4

issue

3

eissn

1061-4036

issn

1546-1718

journal_volume

17

pub_type

杂志文章

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