Ocular retardation mouse caused by Chx10 homeobox null allele: impaired retinal progenitor proliferation and bipolar cell differentiation.


:Ocular retardation (or) is a murine eye mutation causing microphthalmia, a thin hypocellular retina and optic nerve aplasia. Here we show that mice carrying the OrJ allele have a premature stop codon in the homeobox of the Chx10 gene, a gene expressed at high levels in uncommitted retinal progenitor cells and mature bipolar cells. No CHX10 protein was detectable in the retinal neuroepithelium of orJ homozygotes. The loss of CHX10 leads both to reduced proliferation of retinal progenitors and to a specific absence of differentiated bipolar cells. Other major retinal cell types were present and correctly positioned in the mutant retina, although rod outer segments were short and retinal lamination was incomplete. These results indicate that Chx10 is an essential component in the network of genes required for the development of the mammalian eye, with profound effects on retinal progenitor proliferation and bipolar cell specification or differentiation. off


Nat Genet


Nature genetics


Burmeister M,Novak J,Liang MY,Basu S,Ploder L,Hawes NL,Vidgen D,Hoover F,Goldman D,Kalnins VI,Roderick TH,Taylor BA,Hankin MH,McInnes RR




Has Abstract


1996-04-01 00:00:00












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    journal_title:Nature genetics

    pub_type: 杂志文章


    authors: Broughton BC,Steingrimsdottir H,Weber CA,Lehmann AR

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    journal_title:Nature genetics

    pub_type: 杂志文章


    authors: Bulik-Sullivan BK,Loh PR,Finucane HK,Ripke S,Yang J,Schizophrenia Working Group of the Psychiatric Genomics Consortium.,Patterson N,Daly MJ,Price AL,Neale BM

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    journal_title:Nature genetics

    pub_type: 杂志文章


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    pub_type: 杂志文章


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    pub_type: 杂志文章


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    journal_title:Nature genetics

    pub_type: 杂志文章,多中心研究


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    journal_title:Nature genetics

    pub_type: 杂志文章


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    pub_type: 杂志文章


    authors: Barna M,Hawe N,Niswander L,Pandolfi PP

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    pub_type: 杂志文章


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    pub_type: 杂志文章


    authors: Sankararaman S,Obozinski G,Jordan MI,Halperin E

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    pub_type: 杂志文章


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    pub_type: 评论,新闻


    authors: Gordon CT,Lyonnet S

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    pub_type: 杂志文章


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    journal_title:Nature genetics

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    journal_title:Nature genetics

    pub_type: 杂志文章


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    journal_title:Nature genetics

    pub_type: 杂志文章


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    pub_type: 杂志文章


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    journal_title:Nature genetics



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    更新日期:2007-02-01 00:00:00

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    journal_title:Nature genetics

    pub_type: 杂志文章


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    更新日期:2017-01-01 00:00:00

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    pub_type: 杂志文章,meta分析


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    journal_title:Nature genetics

    pub_type: 杂志文章


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    journal_title:Nature genetics

    pub_type: 杂志文章


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    更新日期:1995-07-01 00:00:00

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    journal_title:Nature genetics

    pub_type: 杂志文章


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    更新日期:1998-05-01 00:00:00

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    journal_title:Nature genetics

    pub_type: 杂志文章


    authors: Robert MF,Morin S,Beaulieu N,Gauthier F,Chute IC,Barsalou A,MacLeod AR

    更新日期:2003-01-01 00:00:00