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A brief history of gene therapy.

Abstract：

:The concepts of gene therapy arose initially during the 1960s and early 1970s whilst the development of genetically marked cells lines and the clarification of mechanisms of cell transformation by the papaovaviruses polyoma and SV40 was in progress. With the arrival of recombinant DNA techniques, cloned genes became available and were used to demonstrate that foreign genes could indeed correct genetic defects and disease phenotypes in mammalian cells in vitro. Efficient retroviral vectors and other gene transfer methods have permitted convincing demonstrations of efficient phenotype correction in vitro and in vivo, now making gene therapy a broadly accepted approach to therapy and justifying clinically applied studies with human patients.

journal_name

Nat Genet

journal_title

Nature genetics

authors

Friedmann T

doi

10.1038/ng1092-93

keywords:

subject

Has Abstract

pub_date

1992-10-01 00:00:00

pages

93-8

issue

2

eissn

1061-4036

issn

1546-1718

journal_volume

2

pub_type

历史文章,杂志文章,评审

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