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nagie oko, encoding a MAGUK-family protein, is essential for cellular patterning of the retina.

Abstract：

:A layered organization of cells is a common architectural feature of many neuronal formations. Mutations of the zebrafish gene nagie oko (nok) produce a severe disruption of retinal architecture, indicating a key role for this locus in neuronal patterning. We show that nok encodes a membrane-associated guanylate kinase-family scaffolding protein. Nok localizes to the vicinity of junctional complexes in retinal neuroepithelium and in the photoreceptor cell layer. Mosaic analysis indicates that the nok retinal patterning phenotype is not cell-autonomous. We propose that nok function in patterning of postmitotic neurons is mediated through neuroepithelial cells and is necessary for guiding neurons to their proper destinations in retinal laminae.

journal_name

Nat Genet

journal_title

Nature genetics

authors

Wei X,Malicki J

doi

10.1038/ng883

keywords:

subject

Has Abstract

pub_date

2002-06-01 00:00:00

pages

150-7

issue

2

eissn

1061-4036

issn

1546-1718

pii

ng883

journal_volume

31

pub_type

杂志文章

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