当前位置： SCI文献检索 > NATURE GENETICS期刊下所有文献 > The roles of MAD1, MAD2 and MAD3 in meiotic progression and the segregation of nonexchange chromosomes.

The roles of MAD1, MAD2 and MAD3 in meiotic progression and the segregation of nonexchange chromosomes.

Abstract：

:Errors in meiotic chromosome segregation are the leading cause of spontaneous abortions and birth defects. In humans, chromosomes that fail to experience crossovers (or exchanges) are error-prone, more likely than exchange chromosomes to mis-segregate in meiosis. We used a yeast model to investigate the mechanisms that partition nonexchange chromosomes. These studies showed that the spindle checkpoint genes MAD1, MAD2 and MAD3 have different roles. We identified a new meiotic role for MAD3; though dispensable for the segregation of exchange chromosomes, it is essential for the segregation of nonexchange chromosomes. This function of Mad3p could also be carried out by human BubR1. MAD1 and MAD2 act in a surveillance mechanism that mediates a metaphase delay in response to nonexchange chromosomes, whereas MAD3 acts as a crucial meiotic timer, mediating a prophase delay in every meiosis. These findings suggest plausible models for the basis of errant meiotic segregation in humans.

journal_name

Nat Genet

journal_title

Nature genetics

authors

Cheslock PS,Kemp BJ,Boumil RM,Dawson DS

doi

10.1038/ng1588

keywords:

subject

Has Abstract

pub_date

2005-07-01 00:00:00

pages

756-60

issue

7

eissn

1061-4036

issn

1546-1718

pii

ng1588

journal_volume

37

pub_type

杂志文章

相关文献

NATURE GENETICS文献大全
  • Bayesian inference analyses of the polygenic architecture of rheumatoid arthritis.

    abstract：:The genetic architectures of common, complex diseases are largely uncharacterized. We modeled the genetic architecture underlying genome-wide association study (GWAS) data for rheumatoid arthritis and developed a new method using polygenic risk-score analyses to infer the total liability-scale variance explained by as...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng.2232

    authors： Stahl EA,Wegmann D,Trynka G,Gutierrez-Achury J,Do R,Voight BF,Kraft P,Chen R,Kallberg HJ,Kurreeman FA,Diabetes Genetics Replication and Meta-analysis Consortium.,Myocardial Infarction Genetics Consortium.,Kathiresan S,Wijmenga

    更新日期：2012-03-25 00:00:00

  • Muscle connective tissue controls development of the diaphragm and is a source of congenital diaphragmatic hernias.

    abstract：:The diaphragm is an essential mammalian skeletal muscle, and defects in diaphragm development are the cause of congenital diaphragmatic hernias (CDHs), a common and often lethal birth defect. The diaphragm is derived from multiple embryonic sources, but how these give rise to the diaphragm is unknown, and, despite the...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng.3250

    authors： Merrell AJ,Ellis BJ,Fox ZD,Lawson JA,Weiss JA,Kardon G

    更新日期：2015-05-01 00:00:00

  • Exome sequencing of liver fluke-associated cholangiocarcinoma.

    abstract：:Opisthorchis viverrini-related cholangiocarcinoma (CCA), a fatal bile duct cancer, is a major public health concern in areas endemic for this parasite. We report here whole-exome sequencing of eight O. viverrini-related tumors and matched normal tissue. We identified and validated 206 somatic mutations in 187 genes us...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng.2273

    authors： Ong CK,Subimerb C,Pairojkul C,Wongkham S,Cutcutache I,Yu W,McPherson JR,Allen GE,Ng CC,Wong BH,Myint SS,Rajasegaran V,Heng HL,Gan A,Zang ZJ,Wu Y,Wu J,Lee MH,Huang D,Ong P,Chan-on W,Cao Y,Qian CN,Lim KH,Ooi

    更新日期：2012-05-06 00:00:00

  • Genome-wide association study identifies a common variant associated with risk of endometrial cancer.

    abstract：:Endometrial cancer is the most common malignancy of the female genital tract in developed countries. To identify genetic variants associated with endometrial cancer risk, we performed a genome-wide association study involving 1,265 individuals with endometrial cancer (cases) from Australia and the UK and 5,190 control...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng.812

    authors： Spurdle AB,Thompson DJ,Ahmed S,Ferguson K,Healey CS,O'Mara T,Walker LC,Montgomery SB,Dermitzakis ET,Australian National Endometrial Cancer Study Group.,Fahey P,Montgomery GW,Webb PM,Fasching PA,Beckmann MW,Ekici AB,Hein A

    更新日期：2011-05-01 00:00:00

  • Genetic and epigenetic incompatibilities underlie hybrid dysgenesis in Peromyscus.

    abstract：:Crosses between the two North American rodent species Peromyscus polionotus (PO) and Peromyscus maniculatus (BW) yield parent-of-origin effects on both embryonic and placental growth. The two species are approximately the same size, but a female BW crossed with a male PO produces offspring that are smaller than either...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/75518

    authors： Vrana PB,Fossella JA,Matteson P,del Rio T,O'Neill MJ,Tilghman SM

    更新日期：2000-05-01 00:00:00

  • Human homologs of a Drosophila Enhancer of split gene product define a novel family of nuclear proteins.

    abstract：:Notch and the m9/10 gene (groucho) of the Enhancer of split (E(spI)) complex are members of the "Notch group" of genes, which is required for a variety of cell fate choices in Drosophila. We have characterized human cDNA clones encoding a family of proteins, designated TLE, that are homologous to the E(spI) m9/10 gene...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng1092-119

    authors： Stifani S,Blaumueller CM,Redhead NJ,Hill RE,Artavanis-Tsakonas S

    更新日期：1992-10-01 00:00:00

  • Pyruvate kinase deficiency in mice protects against malaria.

    abstract：:The global health impact of malaria is enormous, with an estimated 300-500 million clinical cases and 1 million annual deaths. In humans, initial susceptibility to infection with Plasmodium species, disease severity and ultimate outcome of malaria (self-healing or lethal) are under complex genetic control. Alleles ass...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng1260

    authors： Min-Oo G,Fortin A,Tam MF,Nantel A,Stevenson MM,Gros P

    更新日期：2003-12-01 00:00:00

  • Identification of Grf1 on mouse chromosome 9 as an imprinted gene by RLGS-M.

    abstract：:Normal mammalian development requires a diploid combination of both haploid parental genomes. Uniparental disomy for certain segments of specific chromosomes results in aberrant development or prenatal lethality, indicating that the parental genomes have undergone modifications during gametogenesis. These modification...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng0996-106

    authors： Plass C,Shibata H,Kalcheva I,Mullins L,Kotelevtseva N,Mullins J,Kato R,Sasaki H,Hirotsune S,Okazaki Y,Held WA,Hayashizaki Y,Chapman VM

    更新日期：1996-09-01 00:00:00

  • A mouse model for spinal muscular atrophy.

    abstract：:The survival motor neuron gene is present in humans in a telomeric copy, SMN1, and several centromeric copies, SMN2. Homozygous mutation of SMN1 is associated with proximal spinal muscular atrophy (SMA), a severe motor neuron disease characterized by early childhood onset of progressive muscle weakness. To understand ...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/71709

    authors： Hsieh-Li HM,Chang JG,Jong YJ,Wu MH,Wang NM,Tsai CH,Li H

    更新日期：2000-01-01 00:00:00

  • Refsum disease is caused by mutations in the phytanoyl-CoA hydroxylase gene.

    abstract：:Refsum disease is an autosomal-recessively inherited disorder characterized clinically by a tetrad of abnormalities: retinitis pigmentosa, peripheral neuropathy, cerebellar ataxia and elevated protein levels in the cerebrospinal fluid (CSF) without an increase in the number of cells in the CSF. All patients exhibit ac...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng1097-190

    authors： Jansen GA,Ofman R,Ferdinandusse S,Ijlst L,Muijsers AO,Skjeldal OH,Stokke O,Jakobs C,Besley GT,Wraith JE,Wanders RJ

    更新日期：1997-10-01 00:00:00

  • Biochemical networking contributes more to genetic buffering in human and mouse metabolic pathways than does gene duplication.

    abstract：:During evolution different genes evolve at unequal rates, reflecting the varying functional constraints on phenotype. An important contributor to this variation is genetic buffering, which reduces the potential detrimental effects of mutations. We studied whether gene duplication and redundant metabolic networks affec...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng945

    authors： Kitami T,Nadeau JH

    更新日期：2002-09-01 00:00:00

  • Dense fine-mapping study identifies new susceptibility loci for primary biliary cirrhosis.

    abstract：:We genotyped 2,861 cases of primary biliary cirrhosis (PBC) from the UK PBC Consortium and 8,514 UK population controls across 196,524 variants within 186 known autoimmune risk loci. We identified 3 loci newly associated with PBC (at P<5×10(-8)), increasing the number of known susceptibility loci to 25. The most assoc...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng.2395

    authors： Liu JZ,Almarri MA,Gaffney DJ,Mells GF,Jostins L,Cordell HJ,Ducker SJ,Day DB,Heneghan MA,Neuberger JM,Donaldson PT,Bathgate AJ,Burroughs A,Davies MH,Jones DE,Alexander GJ,Barrett JC,Sandford RN,Anderson CA,UK Primary

    更新日期：2012-10-01 00:00:00

  • Molecular portraits and the family tree of cancer.

    abstract：:The twenty-first century heralds a new era for the biological sciences and medicine. The tools of our time are allowing us to analyze complex genomes more comprehensively than ever before. A principal technology contributing to this explosion of information is the DNA microarray, which enables us to study genome-wide ...

    journal_title：Nature genetics

    pub_type： 杂志文章,评审

    doi：10.1038/ng1038

    authors： Chung CH,Bernard PS,Perou CM

    更新日期：2002-12-01 00:00:00

  • Genetic variation of a bacterial pathogen within individuals with cystic fibrosis provides a record of selective pressures.

    abstract：:Advances in sequencing technologies have enabled the identification of mutations acquired by bacterial pathogens during infection. However, it remains unclear whether adaptive mutations fix in the population or lead to pathogen diversification within the patient. Here we study the genotypic diversity of Burkholderia d...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng.2848

    authors： Lieberman TD,Flett KB,Yelin I,Martin TR,McAdam AJ,Priebe GP,Kishony R

    更新日期：2014-01-01 00:00:00

  • Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease.

    abstract：:We performed a meta-analysis of 14 genome-wide association studies of coronary artery disease (CAD) comprising 22,233 individuals with CAD (cases) and 64,762 controls of European descent followed by genotyping of top association signals in 56,682 additional individuals. This analysis identified 13 loci newly associate...

    journal_title：Nature genetics

    pub_type： 杂志文章,meta分析

    doi：10.1038/ng.784

    authors： Schunkert H,König IR,Kathiresan S,Reilly MP,Assimes TL,Holm H,Preuss M,Stewart AF,Barbalic M,Gieger C,Absher D,Aherrahrou Z,Allayee H,Altshuler D,Anand SS,Andersen K,Anderson JL,Ardissino D,Ball SG,Balmforth AJ,Ba

    更新日期：2011-03-06 00:00:00

  • Genome-wide association study identifies multiple susceptibility loci for pulmonary fibrosis.

    abstract：:We performed a genome-wide association study of non-Hispanic, white individuals with fibrotic idiopathic interstitial pneumonias (IIPs; n = 1,616) and controls (n = 4,683), with follow-up replication analyses in 876 cases and 1,890 controls. We confirmed association with TERT at 5p15, MUC5B at 11p15 and the 3q26 regio...

    journal_title：Nature genetics

    pub_type： 杂志文章,meta分析

    doi：10.1038/ng.2609

    authors： Fingerlin TE,Murphy E,Zhang W,Peljto AL,Brown KK,Steele MP,Loyd JE,Cosgrove GP,Lynch D,Groshong S,Collard HR,Wolters PJ,Bradford WZ,Kossen K,Seiwert SD,du Bois RM,Garcia CK,Devine MS,Gudmundsson G,Isaksson HJ,Kami

    更新日期：2013-06-01 00:00:00

  • The noncoding RNAs SNORD50A and SNORD50B bind K-Ras and are recurrently deleted in human cancer.

    abstract：:Small nucleolar RNAs (snoRNAs) are conserved noncoding RNAs best studied as ribonucleoprotein (RNP) guides in RNA modification. To explore their role in cancer, we compared 5,473 tumor-normal genome pairs to identify snoRNAs with frequent copy number loss. The SNORD50A-SNORD50B snoRNA locus was deleted in 10-40% of 12...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng.3452

    authors： Siprashvili Z,Webster DE,Johnston D,Shenoy RM,Ungewickell AJ,Bhaduri A,Flockhart R,Zarnegar BJ,Che Y,Meschi F,Puglisi JD,Khavari PA

    更新日期：2016-01-01 00:00:00

  • Transcriptome analysis of the acoelomate human parasite Schistosoma mansoni.

    abstract：:Schistosoma mansoni is the primary causative agent of schistosomiasis, which affects 200 million individuals in 74 countries. We generated 163,000 expressed-sequence tags (ESTs) from normalized cDNA libraries from six selected developmental stages of the parasite, resulting in 31,000 assembled sequences and 92% sampli...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng1237

    authors： Verjovski-Almeida S,DeMarco R,Martins EA,Guimarães PE,Ojopi EP,Paquola AC,Piazza JP,Nishiyama MY Jr,Kitajima JP,Adamson RE,Ashton PD,Bonaldo MF,Coulson PS,Dillon GP,Farias LP,Gregorio SP,Ho PL,Leite RA,Malaquias LC,

    更新日期：2003-10-01 00:00:00

  • The pallid gene encodes a novel, syntaxin 13-interacting protein involved in platelet storage pool deficiency.

    abstract：:Pallid (pa) is 1 of 13 platelet storage pool deficiency (SPD) mouse mutants. pa animals suffer from prolonged bleeding time, pigment dilution, kidney lysosomal enzyme elevation, serum alpha1-antitrypsin activity deficiency and abnormal otolith formation. As with other mouse mutants of this class, characterization of p...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/15507

    authors： Huang L,Kuo YM,Gitschier J

    更新日期：1999-11-01 00:00:00

  • Mutations in the fibroblast growth factor receptor 2 gene cause Crouzon syndrome.

    abstract：:Crouzon syndrome is an autosomal dominant condition causing premature fusion of the cranial sutures (craniosynostosis) and maps to chromosome 10q25-q26. We now present evidence that mutations in the fibroblast growth factor receptor 2 gene (FGFR2) cause Crouzon syndrome. We found SSCP variations in the B exon of FGFR2...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng0994-98

    authors： Reardon W,Winter RM,Rutland P,Pulleyn LJ,Jones BM,Malcolm S

    更新日期：1994-09-01 00:00:00

  • An inducible long noncoding RNA amplifies DNA damage signaling.

    abstract：:Long noncoding RNAs (lncRNAs) are prevalent genes with frequently precise regulation but mostly unknown functions. Here we demonstrate that lncRNAs guide the organismal DNA damage response. DNA damage activated transcription of the DINO (Damage Induced Noncoding) lncRNA via p53. DINO was required for p53-dependent gen...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng.3673

    authors： Schmitt AM,Garcia JT,Hung T,Flynn RA,Shen Y,Qu K,Payumo AY,Peres-da-Silva A,Broz DK,Baum R,Guo S,Chen JK,Attardi LD,Chang HY

    更新日期：2016-11-01 00:00:00

  • Heterozygous missense mutations in BSCL2 are associated with distal hereditary motor neuropathy and Silver syndrome.

    abstract：:Distal hereditary motor neuropathy (dHMN) or distal spinal muscular atrophy (OMIM #182960) is a heterogeneous group of disorders characterized by an almost exclusive degeneration of motor nerve fibers, predominantly in the distal part of the limbs. Silver syndrome (OMIM #270685) is a rare form of hereditary spastic pa...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng1313

    authors： Windpassinger C,Auer-Grumbach M,Irobi J,Patel H,Petek E,Hörl G,Malli R,Reed JA,Dierick I,Verpoorten N,Warner TT,Proukakis C,Van den Bergh P,Verellen C,Van Maldergem L,Merlini L,De Jonghe P,Timmerman V,Crosby AH,Wagn

    更新日期：2004-03-01 00:00:00

  • The genomic landscape of balanced cytogenetic abnormalities associated with human congenital anomalies.

    abstract：:Despite the clinical significance of balanced chromosomal abnormalities (BCAs), their characterization has largely been restricted to cytogenetic resolution. We explored the landscape of BCAs at nucleotide resolution in 273 subjects with a spectrum of congenital anomalies. Whole-genome sequencing revised 93% of karyot...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng.3720

    authors： Redin C,Brand H,Collins RL,Kammin T,Mitchell E,Hodge JC,Hanscom C,Pillalamarri V,Seabra CM,Abbott MA,Abdul-Rahman OA,Aberg E,Adley R,Alcaraz-Estrada SL,Alkuraya FS,An Y,Anderson MA,Antolik C,Anyane-Yeboa K,Atkin JF

    更新日期：2017-01-01 00:00:00

  • Haplotype-resolved genome analyses of a heterozygous diploid potato.

    abstract：:Potato (Solanum tuberosum L.) is the most important tuber crop worldwide. Efforts are underway to transform the crop from a clonally propagated tetraploid into a seed-propagated, inbred-line-based hybrid, but this process requires a better understanding of potato genome. Here, we report the 1.67-Gb haplotype-resolved ...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/s41588-020-0699-x

    authors： Zhou Q,Tang D,Huang W,Yang Z,Zhang Y,Hamilton JP,Visser RGF,Bachem CWB,Robin Buell C,Zhang Z,Zhang C,Huang S

    更新日期：2020-10-01 00:00:00

  • Bioinformatics in the post-sequence era.

    abstract：:In the past decade, bioinformatics has become an integral part of research and development in the biomedical sciences. Bioinformatics now has an essential role both in deciphering genomic, transcriptomic and proteomic data generated by high-throughput experimental technologies and in organizing information gathered fr...

    journal_title：Nature genetics

    pub_type： 历史文章,杂志文章,评审

    doi：10.1038/ng1109

    authors： Kanehisa M,Bork P

    更新日期：2003-03-01 00:00:00

  • OPA1, encoding a dynamin-related GTPase, is mutated in autosomal dominant optic atrophy linked to chromosome 3q28.

    abstract：:Autosomal dominant optic atrophy (ADOA) is the most prevalent hereditary optic neuropathy resulting in progressive loss of visual acuity, centrocoecal scotoma and bilateral temporal atrophy of the optic nerve with an onset within the first two decades of life. The predominant locus for this disorder (OPA1; MIM 165500)...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/79944

    authors： Alexander C,Votruba M,Pesch UE,Thiselton DL,Mayer S,Moore A,Rodriguez M,Kellner U,Leo-Kottler B,Auburger G,Bhattacharya SS,Wissinger B

    更新日期：2000-10-01 00:00:00

  • Convergent evolution of the genomes of marine mammals.

    abstract：:Marine mammals from different mammalian orders share several phenotypic traits adapted to the aquatic environment and therefore represent a classic example of convergent evolution. To investigate convergent evolution at the genomic level, we sequenced and performed de novo assembly of the genomes of three species of m...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng.3198

    authors： Foote AD,Liu Y,Thomas GW,Vinař T,Alföldi J,Deng J,Dugan S,van Elk CE,Hunter ME,Joshi V,Khan Z,Kovar C,Lee SL,Lindblad-Toh K,Mancia A,Nielsen R,Qin X,Qu J,Raney BJ,Vijay N,Wolf JB,Hahn MW,Muzny DM,Worley KC,

    更新日期：2015-03-01 00:00:00

  • Signalling by the W/Kit receptor tyrosine kinase is negatively regulated in vivo by the protein tyrosine phosphatase Shp1.

    abstract：:Protein tyrosine phosphorylation plays a key role in regulating eukaryotic cell proliferation and differentiation. Genetic analysis in invertebrates has been invaluable for dissecting the signalling events downstream of receptor tyrosine kinases (RTKs). We have used this approach in mammals to analyse the interactions...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng0796-309

    authors： Paulson RF,Vesely S,Siminovitch KA,Bernstein A

    更新日期：1996-07-01 00:00:00

  • Fras1 deficiency results in cryptophthalmos, renal agenesis and blebbed phenotype in mice.

    abstract：:Loss of tight association between epidermis and dermis underlies several blistering disorders and is frequently caused by impaired function of extracellular matrix (ECM) proteins. Here we describe a new protein in mouse, Fras1, that is specifically detected in a linear fashion underlying the epidermis and the basal su...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng1168

    authors： Vrontou S,Petrou P,Meyer BI,Galanopoulos VK,Imai K,Yanagi M,Chowdhury K,Scambler PJ,Chalepakis G

    更新日期：2003-06-01 00:00:00

  • Nalp1b controls mouse macrophage susceptibility to anthrax lethal toxin.

    abstract：:The pathogenesis of Bacillus anthracis, the bacterium that causes anthrax, depends on secretion of three factors that combine to form two bipartite toxins. Edema toxin, consisting of protective antigen (PA) and edema factor (EF), causes the edema associated with cutaneous anthrax infections, whereas lethal toxin (LeTx...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng1724

    authors： Boyden ED,Dietrich WF

    更新日期：2006-02-01 00:00:00