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Genetic and epigenetic incompatibilities underlie hybrid dysgenesis in Peromyscus.

Abstract：

:Crosses between the two North American rodent species Peromyscus polionotus (PO) and Peromyscus maniculatus (BW) yield parent-of-origin effects on both embryonic and placental growth. The two species are approximately the same size, but a female BW crossed with a male PO produces offspring that are smaller than either parent. In the reciprocal cross, the offspring are oversized and typically die before birth. Rare survivors are exclusively female, consistent with Haldane's rule, which states that in instances of hybrid sterility or inviability, the heterogametic sex tends to be more severely affected. To understand these sex- and parent-of-origin-specific patterns of overgrowth, we analysed reciprocal backcrosses. Our studies reveal that hybrid inviability is partially due to a maternally expressed X-linked PO locus and an imprinted paternally expressed autosomal BW locus. In addition, the hybrids display skewing of X-chromosome inactivation in favour of the expression of the BW X chromosome. The most severe overgrowth is accompanied by widespread relaxation of imprinting of mostly paternally expressed genes. Both genetic and epigenetic mechanisms underlie hybrid inviability in Peromyscus and hence have a role in the establishment and maintenance of reproductive isolation barriers in mammals.

journal_name

Nat Genet

journal_title

Nature genetics

authors

Vrana PB,Fossella JA,Matteson P,del Rio T,O'Neill MJ,Tilghman SM

doi

10.1038/75518

keywords:

subject

Has Abstract

pub_date

2000-05-01 00:00:00

pages

120-4

issue

1

eissn

1061-4036

issn

1546-1718

journal_volume

25

pub_type

杂志文章

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