Abstract:
:As genetic marker maps have improved, multipoint linkage analysis has become a crucial part of all disease mapping studies. Paradoxically, multipoint lod scores become increasingly difficult to compute, particularly as the numbers of markers, marker alleles and untyped people increase. We have solved this problem by using a novel set-recording scheme to recode each person's genotype and 'fuzzy inheritance' to infer transmission probabilities. Our approach is implemented in a memory-efficient computer program, VITESSE, for extremely rapid computation of exact multipoint likelihoods. VITESSE enables fast and precise multipoint mapping of disease loci with highly polymorphic markers.
journal_name
Nat Genetjournal_title
Nature geneticsauthors
O'Connell JR,Weeks DEdoi
10.1038/ng1295-402subject
Has Abstractpub_date
1995-12-01 00:00:00pages
402-8issue
4eissn
1061-4036issn
1546-1718journal_volume
11pub_type
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