The VITESSE algorithm for rapid exact multilocus linkage analysis via genotype set-recoding and fuzzy inheritance.

Abstract:

:As genetic marker maps have improved, multipoint linkage analysis has become a crucial part of all disease mapping studies. Paradoxically, multipoint lod scores become increasingly difficult to compute, particularly as the numbers of markers, marker alleles and untyped people increase. We have solved this problem by using a novel set-recording scheme to recode each person's genotype and 'fuzzy inheritance' to infer transmission probabilities. Our approach is implemented in a memory-efficient computer program, VITESSE, for extremely rapid computation of exact multipoint likelihoods. VITESSE enables fast and precise multipoint mapping of disease loci with highly polymorphic markers.

journal_name

Nat Genet

journal_title

Nature genetics

authors

O'Connell JR,Weeks DE

doi

10.1038/ng1295-402

subject

Has Abstract

pub_date

1995-12-01 00:00:00

pages

402-8

issue

4

eissn

1061-4036

issn

1546-1718

journal_volume

11

pub_type

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