Abstract:
:Identifying the genes involved in polygenic traits has been difficult. In the 1950s and 1960s, laboratory selection experiments for extreme geotaxic behavior in fruit flies established for the first time that a complex behavioral trait has a genetic basis. But the specific genes responsible for the behavior have never been identified using this classical model. To identify the individual genes involved in geotaxic response, we used cDNA microarrays to identify candidate genes and assessed fly lines mutant in these genes for behavioral confirmation. We have thus determined the identities of several genes that contribute to the complex, polygenic behavior of geotaxis.
journal_name
Nat Genetjournal_title
Nature geneticsauthors
Toma DP,White KP,Hirsch J,Greenspan RJdoi
10.1038/ng893keywords:
subject
Has Abstractpub_date
2002-08-01 00:00:00pages
349-53issue
4eissn
1061-4036issn
1546-1718pii
ng893journal_volume
31pub_type
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