Abstract:
:Protein-protein interactions may impose constraints on both structural and regulatory evolution. Here we show that protein-protein interactions are negatively associated with evolutionary variation in gene expression. Moreover, interacting proteins have similar levels of variation in expression, and their expression levels are positively correlated across strains. Our results suggest that interacting proteins undergo similar evolutionary dynamics, and that their expression levels are evolutionarily coupled. These patterns hold for organisms as diverse as budding yeast and fruit flies.
journal_name
Nat Genetjournal_title
Nature geneticsauthors
Lemos B,Meiklejohn CD,Hartl DLdoi
10.1038/ng1427keywords:
subject
Has Abstractpub_date
2004-10-01 00:00:00pages
1059-60issue
10eissn
1061-4036issn
1546-1718pii
ng1427journal_volume
36pub_type
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