Abstract:
:Manipulation or non-physiological embryo culture environments can lead to defective fetal programming in livestock. Our demonstration of reduced fetal methylation and expression of ovine IGF2R suggests pre-implantation embryo procedures may be vulnerable to epigenetic alterations in imprinted genes. This highlights the potential benefits of epigenetic diagnostic screening in developing embryo procedures.
journal_name
Nat Genetjournal_title
Nature geneticsauthors
Young LE,Fernandes K,McEvoy TG,Butterwith SC,Gutierrez CG,Carolan C,Broadbent PJ,Robinson JJ,Wilmut I,Sinclair KDdoi
10.1038/84769keywords:
subject
Has Abstractpub_date
2001-02-01 00:00:00pages
153-4issue
2eissn
1061-4036issn
1546-1718journal_volume
27pub_type
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