Abstract:
:The apolipoprotein E (APOE) E4 allele is associated with Alzheimer's disease, cardiovascular disease, and decreased longevity. To probe the mechanism of these associations, cell lines were created which secrete each apoE isoform. ApoE conditioned media, purified apoE, and commercially obtained apoE protected B12 cells from hydrogen peroxide cytotoxicity with E2 > E3 > E4. Physiological levels of apoE protected cells from beta-amyloid peptides, while higher doses of apoE led to increased cytotoxicity. E2 > E3 > E4 possessed antioxidant activity, and apoE bound certain metal ions. The decreased antioxidant activity of E4 could contribute to its association with Alzheimer's disease, cardiovascular disease and decreased longevity.
journal_name
Nat Genetjournal_title
Nature geneticsauthors
Miyata M,Smith JDdoi
10.1038/ng0996-55subject
Has Abstractpub_date
1996-09-01 00:00:00pages
55-61issue
1eissn
1061-4036issn
1546-1718journal_volume
14pub_type
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