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Multiple knockout analysis of genetic robustness in the yeast metabolic network.

Abstract：

:Genetic robustness characterizes the constancy of the phenotype in face of heritable perturbations. Previous investigations have used comprehensive single and double gene knockouts to study gene essentiality and pairwise gene interactions in the yeast Saccharomyces cerevisiae. Here we conduct an in silico multiple knockout investigation of a flux balance analysis model of the yeast's metabolic network. Cataloging gene sets that provide mutual functional backup, we identify sets of up to eight interacting genes and characterize the 'k robustness' (the depth of backup interactions) of each gene. We find that 74% (360) of the metabolic genes participate in processes that are essential to growth in a standard laboratory environment, compared with only 13% previously found to be essential using single knockouts. The genes' k robustness is shown to be a solid indicator of their biological buffering capacity and is correlated with both the genes' environmental specificity and their evolutionary retention.

journal_name

Nat Genet

journal_title

Nature genetics

authors

Deutscher D,Meilijson I,Kupiec M,Ruppin E

doi

10.1038/ng1856

subject

Has Abstract

pub_date

2006-09-01 00:00:00

pages

993-8

issue

9

eissn

1061-4036

issn

1546-1718

pii

ng1856

journal_volume

38

pub_type

杂志文章

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