当前位置： SCI文献检索 > NATURE GENETICS期刊下所有文献 > Soluble epoxide hydrolase is a susceptibility factor for heart failure in a rat model of human disease.

Soluble epoxide hydrolase is a susceptibility factor for heart failure in a rat model of human disease.

Abstract：

:We aimed to identify genetic variants associated with heart failure by using a rat model of the human disease. We performed invasive cardiac hemodynamic measurements in F2 crosses between spontaneously hypertensive heart failure (SHHF) rats and reference strains. We combined linkage analyses with genome-wide expression profiling and identified Ephx2 as a heart failure susceptibility gene in SHHF rats. Specifically, we found that cis variation at Ephx2 segregated with heart failure and with increased transcript expression, protein expression and enzyme activity, leading to a more rapid hydrolysis of cardioprotective epoxyeicosatrienoic acids. To confirm our results, we tested the role of Ephx2 in heart failure using knockout mice. Ephx2 gene ablation protected from pressure overload-induced heart failure and cardiac arrhythmias. We further demonstrated differential regulation of EPHX2 in human heart failure, suggesting a cross-species role for Ephx2 in this complex disease.

journal_name

Nat Genet

journal_title

Nature genetics

authors

Monti J,Fischer J,Paskas S,Heinig M,Schulz H,Gösele C,Heuser A,Fischer R,Schmidt C,Schirdewan A,Gross V,Hummel O,Maatz H,Patone G,Saar K,Vingron M,Weldon SM,Lindpaintner K,Hammock BD,Rohde K,Dietz R,Cook SA,Sc

doi

10.1038/ng.129

subject

Has Abstract

pub_date

2008-05-01 00:00:00

pages

529-37

issue

5

eissn

1061-4036

issn

1546-1718

pii

ng.129

journal_volume

40

pub_type

杂志文章

相关文献

NATURE GENETICS文献大全
  • Closing gaps in the human genome with fosmid resources generated from multiple individuals.

    abstract：:The human genome sequence has been finished to very high standards; however, more than 340 gaps remained when the finished genome was published by the International Human Genome Sequencing Consortium in 2004. Using fosmid resources generated from multiple individuals, we targeted gaps in the euchromatic part of the hu...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng.2007.34

    authors： Bovee D,Zhou Y,Haugen E,Wu Z,Hayden HS,Gillett W,Tuzun E,Cooper GM,Sampas N,Phelps K,Levy R,Morrison VA,Sprague J,Jewett D,Buckley D,Subramaniam S,Chang J,Smith DR,Olson MV,Eichler EE,Kaul R

    更新日期：2008-01-01 00:00:00

  • Author Correction: PGBD5 promotes site-specific oncogenic mutations in human tumors.

    abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title：Nature genetics

    pub_type： 已发布勘误

    doi：10.1038/s41588-020-00711-z

    authors： Henssen AG,Koche R,Zhuang J,Jiang E,Reed C,Eisenberg A,Still E,MacArthur IC,Rodríguez-Fos E,Gonzalez S,Puiggròs M,Blackford AN,Mason CE,de Stanchina E,Gönen M,Emde AK,Shah M,Arora K,Reeves C,Socci ND,Perlman E,A

    更新日期：2020-11-01 00:00:00

  • Germline duplication of ATG2B and GSKIP predisposes to familial myeloid malignancies.

    abstract：:No major predisposition gene for familial myeloproliferative neoplasms (MPN) has been identified. Here we demonstrate that the autosomal dominant transmission of a 700-kb duplication in four genetically related families predisposes to myeloid malignancies, including MPN, frequently progressing to leukemia. Using induc...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng.3380

    authors： Saliba J,Saint-Martin C,Di Stefano A,Lenglet G,Marty C,Keren B,Pasquier F,Valle VD,Secardin L,Leroy G,Mahfoudhi E,Grosjean S,Droin N,Diop M,Dessen P,Charrier S,Palazzo A,Merlevede J,Meniane JC,Delaunay-Darivon C,F

    更新日期：2015-10-01 00:00:00

  • Colonic polyposis caused by mTOR-mediated chromosomal instability in Apc+/Delta716 Cdx2+/- compound mutant mice.

    abstract：:The mammalian homeobox transcription factor CDX2 has key roles in intestinal development and differentiation. Heterozygous Cdx2 mice develop one or two benign hamartomas in the proximal colon, whereas heterozygous Apc(Delta716) mice develop numerous adenomatous polyps, mostly in the small intestine. Here we show that ...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng1265

    authors： Aoki K,Tamai Y,Horiike S,Oshima M,Taketo MM

    更新日期：2003-12-01 00:00:00

  • Author Correction: Transcription phenotypes of pancreatic cancer are driven by genomic events during tumor evolution.

    abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title：Nature genetics

    pub_type： 已发布勘误

    doi：10.1038/s41588-020-0588-3

    authors： Chan-Seng-Yue M,Kim JC,Wilson GW,Ng K,Figueroa EF,O'Kane GM,Connor AA,Denroche RE,Grant RC,McLeod J,Wilson JM,Jang GH,Zhang A,Liang SB,Borgida A,Chadwick D,Kalimuthu S,Lungu I,Bartlett JMS,Krzyzanowski PM,Sandhu V

    更新日期：2020-04-01 00:00:00

  • Mutations in RNF135, a gene within the NF1 microdeletion region, cause phenotypic abnormalities including overgrowth.

    abstract：:17q11 microdeletions that encompass NF1 cause 5%-10% of cases of neurofibromatosis type 1, and individuals with microdeletions are typically taller than individuals with intragenic NF1 mutations, suggesting that deletion of a neighboring gene might promote human growth. We identified mutations in RNF135, which is with...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng2083

    authors： Douglas J,Cilliers D,Coleman K,Tatton-Brown K,Barker K,Bernhard B,Burn J,Huson S,Josifova D,Lacombe D,Malik M,Mansour S,Reid E,Cormier-Daire V,Cole T,Childhood Overgrowth Collaboration.,Rahman N

    更新日期：2007-08-01 00:00:00

  • Molecular basis of Thomsen's disease (autosomal dominant myotonia congenita).

    abstract：:Thomsen's disease (autosomal dominant myotonia congenita) has recently been linked to chromosome 7q35 in the region of the human skeletal muscle chloride channel gene (HUMCLC). Single strand conformation polymorphism analysis (SSCP) was used to screen DNA from members of four unrelated pedigrees with this disorder for...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng0493-305

    authors： George AL Jr,Crackower MA,Abdalla JA,Hudson AJ,Ebers GC

    更新日期：1993-04-01 00:00:00

  • Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis.

    abstract：:Sequence variation in human genes is largely confined to single-nucleotide polymorphisms (SNPs) and is valuable in tests of association with common diseases and pharmacogenetic traits. We performed a systematic and comprehensive survey of molecular variation to assess the nature, pattern and frequency of SNPs in 75 ca...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/10297

    authors： Halushka MK,Fan JB,Bentley K,Hsie L,Shen N,Weder A,Cooper R,Lipshutz R,Chakravarti A

    更新日期：1999-07-01 00:00:00

  • Defining the disease liability of variants in the cystic fibrosis transmembrane conductance regulator gene.

    abstract：:Allelic heterogeneity in disease-causing genes presents a substantial challenge to the translation of genomic variation into clinical practice. Few of the almost 2,000 variants in the cystic fibrosis transmembrane conductance regulator gene CFTR have empirical evidence that they cause cystic fibrosis. To address this ...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng.2745

    authors： Sosnay PR,Siklosi KR,Van Goor F,Kaniecki K,Yu H,Sharma N,Ramalho AS,Amaral MD,Dorfman R,Zielenski J,Masica DL,Karchin R,Millen L,Thomas PJ,Patrinos GP,Corey M,Lewis MH,Rommens JM,Castellani C,Penland CM,Cutting GR

    更新日期：2013-10-01 00:00:00

  • Identification of novel genes, SYT and SSX, involved in the t(X;18)(p11.2;q11.2) translocation found in human synovial sarcoma.

    abstract：:Human synovial sarcomas contain a recurrent and specific chromosomal translocation t(X;18)(p11.2;q11.2). By screening a synovial sarcoma cDNA library with a yeast artificial chromosome spanning the X chromosome breakpoint, we have identified a hybrid transcript that contains 5' sequences (designated SYT) mapping to ch...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng0894-502

    authors： Clark J,Rocques PJ,Crew AJ,Gill S,Shipley J,Chan AM,Gusterson BA,Cooper CS

    更新日期：1994-08-01 00:00:00

  • A Y-encoded subunit of the translation initiation factor Eif2 is essential for mouse spermatogenesis.

    abstract：:In mouse and man, deletions of specific regions of the Y chromosome have been linked to early failure of spermatogenesis and consequent sterility; the Y chromosomal gene(s) with this essential early role in spermatogenesis have not been identified. The partial deletion of the mouse Y short arm (the Sxrb deletion) that...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng717

    authors： Mazeyrat S,Saut N,Grigoriev V,Mahadevaiah SK,Ojarikre OA,Rattigan A,Bishop C,Eicher EM,Mitchell MJ,Burgoyne PS

    更新日期：2001-09-01 00:00:00

  • The glial cells missing-1 protein is essential for branching morphogenesis in the chorioallantoic placenta.

    abstract：:Trophoblast cells of the placenta are established at the blastocyst stage and differentiate into specialized subtypes after implantation. In mice, the outer layer of the placenta consists of trophoblast giant cells that invade the uterus and promote maternal blood flow to the implantation site by producing cytokines w...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/77076

    authors： Anson-Cartwright L,Dawson K,Holmyard D,Fisher SJ,Lazzarini RA,Cross JC

    更新日期：2000-07-01 00:00:00

  • Extensive genomic and transcriptional diversity identified through massively parallel DNA and RNA sequencing of eighteen Korean individuals.

    abstract：:Massively parallel sequencing technologies have identified a broad spectrum of human genome diversity. Here we deep sequenced and correlated 18 genomes and 17 transcriptomes of unrelated Korean individuals. This has allowed us to construct a genome-wide map of common and rare variants and also identify variants formed...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng.872

    authors： Ju YS,Kim JI,Kim S,Hong D,Park H,Shin JY,Lee S,Lee WC,Kim S,Yu SB,Park SS,Seo SH,Yun JY,Kim HJ,Lee DS,Yavartanoo M,Kang HP,Gokcumen O,Govindaraju DR,Jung JH,Chong H,Yang KS,Kim H,Lee C,Seo JS

    更新日期：2011-07-03 00:00:00

  • The noncoding RNAs SNORD50A and SNORD50B bind K-Ras and are recurrently deleted in human cancer.

    abstract：:Small nucleolar RNAs (snoRNAs) are conserved noncoding RNAs best studied as ribonucleoprotein (RNP) guides in RNA modification. To explore their role in cancer, we compared 5,473 tumor-normal genome pairs to identify snoRNAs with frequent copy number loss. The SNORD50A-SNORD50B snoRNA locus was deleted in 10-40% of 12...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng.3452

    authors： Siprashvili Z,Webster DE,Johnston D,Shenoy RM,Ungewickell AJ,Bhaduri A,Flockhart R,Zarnegar BJ,Che Y,Meschi F,Puglisi JD,Khavari PA

    更新日期：2016-01-01 00:00:00

  • MASA syndrome is due to mutations in the neural cell adhesion gene L1CAM.

    abstract：:MASA syndrome is a recessive X-linked disorder characterized by mental retardation, adducted thumbs, shuffling gait, aphasia and, in some cases, hydrocephalus. Since it has been shown that X-linked hydrocephalus can be caused by mutations in L1CAM, a neuronal cell adhesion molecule, we performed an L1CAM mutation anal...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng0794-408

    authors： Vits L,Van Camp G,Coucke P,Fransen E,De Boulle K,Reyniers E,Korn B,Poustka A,Wilson G,Schrander-Stumpel C

    更新日期：1994-07-01 00:00:00

  • Mutations in the gene encoding the lamin B receptor produce an altered nuclear morphology in granulocytes (Pelger-Huët anomaly).

    abstract：:Pelger-Huët anomaly (PHA; OMIM *169400) is an autosomal dominant disorder characterized by abnormal nuclear shape and chromatin organization in blood granulocytes. Affected individuals show hypolobulated neutrophil nuclei with coarse chromatin. Presumed homozygous individuals have ovoid neutrophil nuclei, as well as v...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng925

    authors： Hoffmann K,Dreger CK,Olins AL,Olins DE,Shultz LD,Lucke B,Karl H,Kaps R,Müller D,Vayá A,Aznar J,Ware RE,Sotelo Cruz N,Lindner TH,Herrmann H,Reis A,Sperling K

    更新日期：2002-08-01 00:00:00

  • The complete BRCA2 gene and mutations in chromosome 13q-linked kindreds.

    abstract：:Breast carcinoma is the most common malignancy among women in developed countries. Because family history remains the strongest single predictor of breast cancer risk, attention has focused on the role of highly penetrant, dominantly inherited genes in cancer-prone kindreds (1). BRCA1 was localized to chromosome 17 th...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng0396-333

    authors： Tavtigian SV,Simard J,Rommens J,Couch F,Shattuck-Eidens D,Neuhausen S,Merajver S,Thorlacius S,Offit K,Stoppa-Lyonnet D,Belanger C,Bell R,Berry S,Bogden R,Chen Q,Davis T,Dumont M,Frye C,Hattier T,Jammulapati S,Jane

    更新日期：1996-03-01 00:00:00

  • Mutations in a gene encoding a novel protein tyrosine phosphatase cause progressive myoclonus epilepsy.

    abstract：:Lafora's disease (LD; OMIM 254780) is an autosomal recessive form of progressive myoclonus epilepsy characterized by seizures and cumulative neurological deterioration. Onset occurs during late childhood and usually results in death within ten years of the first symptoms. With few exceptions, patients follow a homogen...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/2470

    authors： Minassian BA,Lee JR,Herbrick JA,Huizenga J,Soder S,Mungall AJ,Dunham I,Gardner R,Fong CY,Carpenter S,Jardim L,Satishchandra P,Andermann E,Snead OC 3rd,Lopes-Cendes I,Tsui LC,Delgado-Escueta AV,Rouleau GA,Scherer SW

    更新日期：1998-10-01 00:00:00

  • Natural variation at the DEP1 locus enhances grain yield in rice.

    abstract：:Grain yield is controlled by quantitative trait loci (QTLs) derived from natural variations in many crop plants. Here we report the molecular characterization of a major rice grain yield QTL that acts through the determination of panicle architecture. The dominant allele at the DEP1 locus is a gain-of-function mutatio...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng.352

    authors： Huang X,Qian Q,Liu Z,Sun H,He S,Luo D,Xia G,Chu C,Li J,Fu X

    更新日期：2009-04-01 00:00:00

  • Author Correction: Reference component analysis of single-cell transcriptomes elucidates cellular heterogeneity in human colorectal tumors.

    abstract：:In the version of the article published, the author list is not accurate. Igor Cima and Min-Han Tan should have been authors, appearing after Mark Wong in the author list, while Paul Jongjoon Choi should not have been listed as an author. Igor Cima and Min-Han Tan both have the affiliation Institute of Bioengineering ...

    journal_title：Nature genetics

    pub_type： 杂志文章,已发布勘误

    doi：10.1038/s41588-018-0299-1

    authors： Li H,Courtois ET,Sengupta D,Tan Y,Chen KH,Goh JJL,Kong SL,Chua C,Hon LK,Tan WS,Wong M,Cima I,Tan MH,Wee LJK,Hillmer AM,Tan IB,Robson P,Prabhakar S

    更新日期：2018-12-01 00:00:00

  • Genetic analysis of quantitative traits in the Japanese population links cell types to complex human diseases.

    abstract：:Clinical measurements can be viewed as useful intermediate phenotypes to promote understanding of complex human diseases. To acquire comprehensive insights into the underlying genetics, here we conducted a genome-wide association study (GWAS) of 58 quantitative traits in 162,255 Japanese individuals. Overall, we ident...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/s41588-018-0047-6

    authors： Kanai M,Akiyama M,Takahashi A,Matoba N,Momozawa Y,Ikeda M,Iwata N,Ikegawa S,Hirata M,Matsuda K,Kubo M,Okada Y,Kamatani Y

    更新日期：2018-03-01 00:00:00

  • Publisher Correction: Immune genes are primed for robust transcription by proximal long noncoding RNAs located in nuclear compartments.

    abstract：:In the version of this article initially published, '+' and '-' labels were missing from the graph keys at the bottom of Fig. 8d. The error has been corrected in the HTML and PDF versions of the article. ...

    journal_title：Nature genetics

    pub_type： 杂志文章,已发布勘误

    doi：10.1038/s41588-018-0341-3

    authors： Fanucchi S,Fok ET,Dalla E,Shibayama Y,Börner K,Chang EY,Stoychev S,Imakaev M,Grimm D,Wang KC,Li G,Sung WK,Mhlanga MM

    更新日期：2019-02-01 00:00:00

  • Common variants at 10p12.31, 10q21.1 and 13q12.13 are associated with sporadic pituitary adenoma.

    abstract：:Pituitary adenoma is one of the most common intracranial neoplasms, and its genetic basis remains largely unknown. To identify genetic susceptibility loci for sporadic pituitary adenoma, we performed a three-stage genome-wide association study (GWAS) in the Han Chinese population. We first analyzed genome-wide SNP dat...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng.3322

    authors： Ye Z,Li Z,Wang Y,Mao Y,Shen M,Zhang Q,Li S,Zhou L,Shou X,Chen J,Song Z,Ma Z,Zhang Z,Li Y,Ye H,Huang C,Wang T,He W,Zhang Y,Xie R,Qiao N,Qiu H,Huang S,Wang M,Shen J,Wen Z,Li W,Liu K,Zhou J,Wang L,

    更新日期：2015-07-01 00:00:00

  • Loss-of-function mutations in FGFR1 cause autosomal dominant Kallmann syndrome.

    abstract：:We took advantage of overlapping interstitial deletions at chromosome 8p11-p12 in two individuals with contiguous gene syndromes and defined an interval of roughly 540 kb associated with a dominant form of Kallmann syndrome, KAL2. We establish here that loss-of-function mutations in FGFR1 underlie KAL2 whereas a gain-...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng1122

    authors： Dodé C,Levilliers J,Dupont JM,De Paepe A,Le Dû N,Soussi-Yanicostas N,Coimbra RS,Delmaghani S,Compain-Nouaille S,Baverel F,Pêcheux C,Le Tessier D,Cruaud C,Delpech M,Speleman F,Vermeulen S,Amalfitano A,Bachelot Y,Boucha

    更新日期：2003-04-01 00:00:00

  • Variants with large effects on blood lipids and the role of cholesterol and triglycerides in coronary disease.

    abstract：:Sequence variants affecting blood lipids and coronary artery disease (CAD) may enhance understanding of the atherogenicity of lipid fractions. Using a large resource of whole-genome sequence data, we examined rare and low-frequency variants for association with non-HDL cholesterol, HDL cholesterol, LDL cholesterol, an...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng.3561

    authors： Helgadottir A,Gretarsdottir S,Thorleifsson G,Hjartarson E,Sigurdsson A,Magnusdottir A,Jonasdottir A,Kristjansson H,Sulem P,Oddsson A,Sveinbjornsson G,Steinthorsdottir V,Rafnar T,Masson G,Jonsdottir I,Olafsson I,Eyjolfsson

    更新日期：2016-06-01 00:00:00

  • Localization to Xq27 of a susceptibility gene for testicular germ-cell tumours.

    abstract：:Testicular germ-cell tumours (TGCT) affect 1 in 500 men and are the most common cancer in males aged 15-40 in Western European populations. The incidence of TGCT has risen dramatically over the last century. Known risk factors for TGCT include a history of undescended testis (UDT), testicular dysgenesis, infertility, ...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/72877

    authors： Rapley EA,Crockford GP,Teare D,Biggs P,Seal S,Barfoot R,Edwards S,Hamoudi R,Heimdal K,Fossâ SD,Tucker K,Donald J,Collins F,Friedlander M,Hogg D,Goss P,Heidenreich A,Ormiston W,Daly PA,Forman D,Oliver TD,Leahy M

    更新日期：2000-02-01 00:00:00

  • Association of the INS VNTR with size at birth. ALSPAC Study Team. Avon Longitudinal Study of Pregnancy and Childhood.

    abstract：:Size at birth is an important determinant of perinatal survival and has also been associated with the risk for cardiovascular disease and type 2 diabetes in adult life. Common genetic variation that regulates fetal growth could therefore influence perinatal survival and predispose to the development of adult disease. ...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng0598-98

    authors： Dunger DB,Ong KK,Huxtable SJ,Sherriff A,Woods KA,Ahmed ML,Golding J,Pembrey ME,Ring S,Bennett ST,Todd JA

    更新日期：1998-05-01 00:00:00

  • Renal disease susceptibility and hypertension are under independent genetic control in the fawn-hooded rat.

    abstract：:Hypertension, diabetes and hyperlipidemia are risk factors for life-threatening complications such as end-stage renal disease, coronary artery disease and stroke. Why some patients develop complications is unclear, but only susceptibility genes may be involved. To test this notion, we studied crosses involving the faw...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng0196-44

    authors： Brown DM,Provoost AP,Daly MJ,Lander ES,Jacob HJ

    更新日期：1996-01-01 00:00:00

  • Substitutions in woolly mammoth hemoglobin confer biochemical properties adaptive for cold tolerance.

    abstract：:We have genetically retrieved, resurrected and performed detailed structure-function analyses on authentic woolly mammoth hemoglobin to reveal for the first time both the evolutionary origins and the structural underpinnings of a key adaptive physiochemical trait in an extinct species. Hemoglobin binds and carries O(2...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng.574

    authors： Campbell KL,Roberts JE,Watson LN,Stetefeld J,Sloan AM,Signore AV,Howatt JW,Tame JR,Rohland N,Shen TJ,Austin JJ,Hofreiter M,Ho C,Weber RE,Cooper A

    更新日期：2010-06-01 00:00:00

  • Mutation of DNASE1 in people with systemic lupus erythematosus.

    abstract：:Systemic lupus erythematosus (SLE) is a highly prevalent human autoimmune diseases that causes progressive glomerulonephritis, arthritis and an erythematoid rash. Mice deficient in deoxyribonuclease I (Dnase1) develop an SLE-like syndrome. Here we describe two patients with a heterozygous nonsense mutation in exon 2 o...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/91070

    authors： Yasutomo K,Horiuchi T,Kagami S,Tsukamoto H,Hashimura C,Urushihara M,Kuroda Y

    更新日期：2001-08-01 00:00:00