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Susceptibility to insulin dependent diabetes mellitus maps to a 4.1 kb segment of DNA spanning the insulin gene and associated VNTR.

Abstract：

:Recent studies have demonstrated that a locus at 11p15.5 confers susceptibility to insulin dependent diabetes mellitus (IDDM). This locus has been shown to lie within a 19 kb region. We present a detailed sequence comparison of the predominant haplotypes found in this region in a population of French Caucasian IDDM patients and controls. Identification of polymorphisms both associated and unassociated with IDDM has allowed us to define further the region of association to 4.1 kb. Ten polymorphisms within this region are in strong linkage disequilibrium with each other and extend across the insulin gene locus and the variable number tandem repeat (VNTR) situated immediately 5' to the insulin gene. These represent a set of candidate disease polymorphisms one or more of which may account for the susceptibility to IDDM.

journal_name

Nat Genet

journal_title

Nature genetics

authors

Lucassen AM,Julier C,Beressi JP,Boitard C,Froguel P,Lathrop M,Bell JI

doi

10.1038/ng0793-305

subject

Has Abstract

pub_date

1993-07-01 00:00:00

pages

305-10

issue

3

eissn

1061-4036

issn

1546-1718

journal_volume

4

pub_type

杂志文章

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