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Pleiotropic fitness effects of the Tre1-Gr5a region in Drosophila melanogaster.

Abstract：

:The abundance of transposable elements and DNA repeat sequences in mammalian genomes raises the question of whether such insertions represent passive evolutionary baggage or may influence the expression of complex traits. We addressed this question in Drosophila melanogaster, in which the effects of single transposable elements on complex traits can be assessed in genetically identical individuals reared in controlled environments. Here we demonstrate that single P-element insertions in the intergenic region between the gustatory receptor 5a (Gr5a, also known as Tre) and trapped in endoderm 1 (Tre1), which encodes an orphan receptor, exert complex pleiotropic effects on fitness traits, including selective nutrient intake, life span, and resistance to starvation and heat stress. Mutations in this region interact epistatically with downstream components of the insulin signaling pathway. Transposon-induced sex-specific and sex-antagonistic effects further accentuate the complex influences that intergenic transposable elements can contribute to quantitative trait phenotypes.

journal_name

Nat Genet

journal_title

Nature genetics

authors

Rollmann SM,Magwire MM,Morgan TJ,Ozsoy ED,Yamamoto A,Mackay TF,Anholt RR

doi

10.1038/ng1823

subject

Has Abstract

pub_date

2006-07-01 00:00:00

pages

824-9

issue

7

eissn

1061-4036

issn

1546-1718

pii

ng1823

journal_volume

38

pub_type

杂志文章

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