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Renal disease susceptibility and hypertension are under independent genetic control in the fawn-hooded rat.

Abstract：

:Hypertension, diabetes and hyperlipidemia are risk factors for life-threatening complications such as end-stage renal disease, coronary artery disease and stroke. Why some patients develop complications is unclear, but only susceptibility genes may be involved. To test this notion, we studied crosses involving the fawn-hooded rat, an animal model of hypertension that develops chronic renal failure. Here, we report the localization of two genes, Rf-1 and Rf-2, responsible for about half of the genetic variation in key indices of renal impairment. In addition, we localize a gene, Bpfh-1, responsible for about 26% of the genetic variation in blood pressure. Rf-1 strongly affects the risk of renal impairment, but has no significant effect on blood pressure. Our results show that susceptibility to a complication of hypertension is under at least partially independent genetic control from susceptibility to hypertension itself.

journal_name

Nat Genet

journal_title

Nature genetics

authors

Brown DM,Provoost AP,Daly MJ,Lander ES,Jacob HJ

doi

10.1038/ng0196-44

subject

Has Abstract

pub_date

1996-01-01 00:00:00

pages

44-51

issue

1

eissn

1061-4036

issn

1546-1718

journal_volume

12

pub_type

杂志文章

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