Abstract:
:The CRISPR-Cas9 system enables global screens of gene function with high sensitivity and specificity, but off-target effects have been reported for CRISPR guide RNAs targeting genes that are amplified at high copy number. A new study describes a computational approach to correct for this copy number effect, increasing the specificity of CRIPSR screens to identify essential genes.
journal_name
Nat Genetjournal_title
Nature geneticsauthors
Shen JP,Ideker Tdoi
10.1038/ng.3994subject
Has Abstractpub_date
2017-11-29 00:00:00pages
1674-1675issue
12eissn
1061-4036issn
1546-1718pii
ng.3994journal_volume
49pub_type
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