Abstract:
:A scarlet fever outbreak began in mainland China and Hong Kong in 2011 (refs. 1-6). Macrolide- and tetracycline-resistant Streptococcus pyogenes emm12 isolates represent the majority of clinical cases. Recently, we identified two mobile genetic elements that were closely associated with emm12 outbreak isolates: the integrative and conjugative element ICE-emm12, encoding genes for tetracycline and macrolide resistance, and prophage ΦHKU.vir, encoding the superantigens SSA and SpeC, as well as the DNase Spd1 (ref. 4). Here we sequenced the genomes of 141 emm12 isolates, including 132 isolated in Hong Kong between 2005 and 2011. We found that the introduction of several ICE-emm12 variants, ΦHKU.vir and a new prophage, ΦHKU.ssa, occurred in three distinct emm12 lineages late in the twentieth century. Acquisition of ssa and transposable elements encoding multidrug resistance genes triggered the expansion of scarlet fever-associated emm12 lineages in Hong Kong. The occurrence of multidrug-resistant ssa-harboring scarlet fever strains should prompt heightened surveillance within China and abroad for the dissemination of these mobile genetic elements.
journal_name
Nat Genetjournal_title
Nature geneticsauthors
Davies MR,Holden MT,Coupland P,Chen JH,Venturini C,Barnett TC,Zakour NL,Tse H,Dougan G,Yuen KY,Walker MJdoi
10.1038/ng.3147subject
Has Abstractpub_date
2015-01-01 00:00:00pages
84-7issue
1eissn
1061-4036issn
1546-1718pii
ng.3147journal_volume
47pub_type
杂志文章相关文献
NATURE GENETICS文献大全abstract::Although ribosomes are ubiquitous and essential for life, recent data indicate that monogenic causes of ribosomal dysfunction can confer a remarkable degree of specificity in terms of human disease phenotype. Box C/D small nucleolar RNAs (snoRNAs) are evolutionarily conserved non-protein-coding RNAs involved in riboso...
journal_title:Nature genetics
pub_type: 杂志文章
doi:10.1038/ng.3661
更新日期:2016-10-01 00:00:00
abstract::Using microarrays, we identified de novo copy number variations in the SHANK2 synaptic scaffolding gene in two unrelated individuals with autism-spectrum disorder (ASD) and mental retardation. DNA sequencing of SHANK2 in 396 individuals with ASD, 184 individuals with mental retardation and 659 unaffected individuals (...
journal_title:Nature genetics
pub_type: 杂志文章
doi:10.1038/ng.589
更新日期:2010-06-01 00:00:00
abstract::Numerous genetic loci have been associated with systolic blood pressure (SBP) and diastolic blood pressure (DBP) in Europeans. We now report genome-wide association studies of pulse pressure (PP) and mean arterial pressure (MAP). In discovery (N = 74,064) and follow-up studies (N = 48,607), we identified at genome-wid...
journal_title:Nature genetics
pub_type: 杂志文章,meta分析
doi:10.1038/ng.922
更新日期:2011-09-11 00:00:00
abstract::The three-dimensional organization of the genome has an important role in orchestrating gene expression, but its regulation is poorly understood. Now, a new study uncovers a major role for Polycomb components of the PRC1 complex in organizing physical networks of genes that are co-repressed to maintain pluripotency. ...
journal_title:Nature genetics
pub_type: 评论,新闻
doi:10.1038/ng.3411
更新日期:2015-10-01 00:00:00
abstract::The Polycomb repressive complexes PRC1 and PRC2 maintain embryonic stem cell (ESC) pluripotency by silencing lineage-specifying developmental regulator genes. Emerging evidence suggests that Polycomb complexes act through controlling spatial genome organization. We show that PRC1 functions as a master regulator of mou...
journal_title:Nature genetics
pub_type: 杂志文章
doi:10.1038/ng.3393
更新日期:2015-10-01 00:00:00
abstract::Although Burkitt lymphomas and follicular lymphomas both have features of germinal center B cells, they are biologically and clinically quite distinct. Here we performed whole-genome bisulfite, genome and transcriptome sequencing in 13 IG-MYC translocation-positive Burkitt lymphoma, nine BCL2 translocation-positive fo...
journal_title:Nature genetics
pub_type: 杂志文章
doi:10.1038/ng.3413
更新日期:2015-11-01 00:00:00
abstract::We report the 207-Mb genome sequence of the North American Arabidopsis lyrata strain MN47 based on 8.3× dideoxy sequence coverage. We predict 32,670 genes in this outcrossing species compared to the 27,025 genes in the selfing species Arabidopsis thaliana. The much smaller 125-Mb genome of A. thaliana, which diverged ...
journal_title:Nature genetics
pub_type: 杂志文章
doi:10.1038/ng.807
更新日期:2011-05-01 00:00:00
abstract::Pioneer transcription factors establish new cell-fate competence by triggering chromatin remodeling. However, many features of pioneer action, such as their kinetics and stability, remain poorly defined. Here, we show that Pax7, by opening a unique repertoire of enhancers, is necessary and sufficient for specification...
journal_title:Nature genetics
pub_type: 杂志文章
doi:10.1038/s41588-017-0035-2
更新日期:2018-02-01 00:00:00
abstract::The vast majority of patients with fragile X syndrome show a folate-sensitive fragile site at Xq27.3 (FRAXA) at the cytogenetic level, and both amplification of the (CGG)n repeat and hypermethylation of the CpG island in the 5' fragile X gene (FMR-1) at the molecular level. We have studied the FMR-1 gene of a patient ...
journal_title:Nature genetics
pub_type: 杂志文章
doi:10.1038/ng0193-31
更新日期:1993-01-01 00:00:00
abstract::Consistent but indirect evidence has implicated genetic factors in smoking behavior. We report meta-analyses of several smoking phenotypes within cohorts of the Tobacco and Genetics Consortium (n = 74,053). We also partnered with the European Network of Genetic and Genomic Epidemiology (ENGAGE) and Oxford-GlaxoSmithKl...
journal_title:Nature genetics
pub_type: 杂志文章,meta分析
doi:10.1038/ng.571
更新日期:2010-05-01 00:00:00
abstract::The cardiac homeobox protein Nkx2-5 is essential in cardiac development, and mutations in Csx (which encodes Nkx2-5) cause various congenital heart diseases. Using the yeast two-hybrid system with Nkx2-5 as the 'bait', we isolated the T-box-containing transcription factor Tbx5; mutations in TBX5 cause heart and limb m...
journal_title:Nature genetics
pub_type: 杂志文章
doi:10.1038/90123
更新日期:2001-07-01 00:00:00
abstract::It is generally assumed that the male:female (M:F) ratio in patients with type 1 (insulin-dependent) diabetes mellitus (IDDM) is 1. A recent survey, however, revealed that high incidence countries (mainly European) have a high M:F ratio and low incidence ones (Asian and African) have a low M:F ratio. We have now analy...
journal_title:Nature genetics
pub_type: 杂志文章
doi:10.1038/995
更新日期:1998-07-01 00:00:00
abstract::Regulatory variants are often context specific, modulating gene expression in a subset of possible cellular states. Although these genetic effects can play important roles in disease, the molecular mechanisms underlying context specificity are poorly understood. Here, we identified shared quantitative trait loci (QTLs...
journal_title:Nature genetics
pub_type: 杂志文章
doi:10.1038/s41588-018-0046-7
更新日期:2018-03-01 00:00:00
abstract::From chromosomal region 17q21.3, where a tumour suppressor gene(s) for breast and ovarian cancers is thought to be present, we have isolated a novel gene from a cosmid clone that revealed somatic rearrangements in two breast cancers. The gene (MDC) encodes a 524-amino acid metalloprotease-like, disintegrin-like and cy...
journal_title:Nature genetics
pub_type: 杂志文章
doi:10.1038/ng1093-151
更新日期:1993-10-01 00:00:00
abstract::The importance of individual microRNAs (miRNAs) has been established in specific cancers. However, a comprehensive analysis of the contribution of miRNAs to the pathogenesis of any specific cancer is lacking. Here we show that in T-cell acute lymphoblastic leukemia (T-ALL), a small set of miRNAs is responsible for the...
journal_title:Nature genetics
pub_type: 杂志文章
doi:10.1038/ng.858
更新日期:2011-06-05 00:00:00
abstract::Charcot-Marie-Tooth disease type 1B (CMT1B) is genetically linked to chromosome 1q21-23. The major peripheral myelin protein gene, P0, has been cloned and localized to the same chromosomal region. P0 is a 28 kDa glycoprotein involved in the compaction of the multilamellar myelin sheet and accounts for more than half o...
journal_title:Nature genetics
pub_type: 杂志文章
doi:10.1038/ng0993-35
更新日期:1993-09-01 00:00:00
abstract::Cell fate during development is defined by transcription factors that act as molecular switches to activate or repress specific gene expression programmes. The POU transcription factor Oct-3/4 (encoded by Pou5f1) is a candidate regulator in pluripotent and germline cells and is essential for the initial formation of a...
journal_title:Nature genetics
pub_type: 杂志文章
doi:10.1038/74199
更新日期:2000-04-01 00:00:00
abstract::New genetic data has enabled scientists to re-examine the relationship between human genetic variation and 'race'. We review the results of genetic analyses that show that human genetic variation is geographically structured, in accord with historical patterns of gene flow and genetic drift. Analysis of many loci now ...
journal_title:Nature genetics
pub_type: 杂志文章
doi:10.1038/ng1435
更新日期:2004-11-01 00:00:00
abstract::Altering cytosine methylation by genetic means leads to a variety of developmental defects in mice, plants and fungi. Deregulation of cytosine methylation also has a role in human carcinogenesis. In some cases, these defects have been tied to the inheritance of epigenetic alterations (such as chromatin imprints and DN...
journal_title:Nature genetics
pub_type: 杂志文章
doi:10.1038/8803
更新日期:1999-05-01 00:00:00
abstract::How the human brain rapidly builds up its lipid content during brain growth and maintains its lipids in adulthood has remained elusive. Two new studies show that inactivating mutations in MFSD2A, known to be expressed specifically at the blood-brain barrier, lead to microcephaly, thereby offering a simple and surprisi...
journal_title:Nature genetics
pub_type: 杂志文章
doi:10.1038/ng.3348
更新日期:2015-07-01 00:00:00
abstract::PDGF-C is a member of the platelet-derived growth factor (PDGF) family, which signals through PDGF receptor (PDGFR) alphaalpha and alphabeta dimers. Here we show that Pdgfc(-/-) mice die in the perinatal period owing to feeding and respiratory difficulties associated with a complete cleft of the secondary palate. This...
journal_title:Nature genetics
pub_type: 杂志文章
doi:10.1038/ng1415
更新日期:2004-10-01 00:00:00
abstract::Expansion of trinucleotide repeats can give rise to genetic disease. We have developed a technique, repeat expansion detection (RED), that can identify potentially pathological repeat expansion without prior knowledge of chromosomal location. Human genomic DNA is used as a template for a two-step cycling process that ...
journal_title:Nature genetics
pub_type: 杂志文章
doi:10.1038/ng0693-135
更新日期:1993-06-01 00:00:00
abstract::Gains and losses in DNA methylation are prominent features of mammalian cell types. To gain insight into the mechanisms that promote shifts in DNA methylation and contribute to changes in cell fate, including malignant transformation, we performed genome-wide mapping of 5-methylcytosine and 5-hydroxymethylcytosine in ...
journal_title:Nature genetics
pub_type: 杂志文章
doi:10.1038/ng.2836
更新日期:2014-01-01 00:00:00
abstract::Desmin-related myopathies (DRM) are inherited neuromuscular disorders characterized by adult onset and delayed accumulation of aggregates of desmin, a protein belonging to the type III intermediate filament family, in the sarcoplasma of skeletal and cardiac muscles. In this paper, we have mapped the locus for DRM in a...
journal_title:Nature genetics
pub_type: 杂志文章
doi:10.1038/1765
更新日期:1998-09-01 00:00:00
abstract::Alcohol misuse is the leading cause of cirrhosis and the second most common indication for liver transplantation in the Western world. We performed a genome-wide association study for alcohol-related cirrhosis in individuals of European descent (712 cases and 1,426 controls) with subsequent validation in two independe...
journal_title:Nature genetics
pub_type: 杂志文章
doi:10.1038/ng.3417
更新日期:2015-12-01 00:00:00
abstract::A major challenge in inflammatory bowel disease (IBD) is the integration of diverse IBD data sets to construct predictive models of IBD. We present a predictive model of the immune component of IBD that informs causal relationships among loci previously linked to IBD through genome-wide association studies (GWAS) usin...
journal_title:Nature genetics
pub_type: 杂志文章
doi:10.1038/ng.3947
更新日期:2017-10-01 00:00:00
abstract::The genetic basis of most conditions characterized by congenital contractures is largely unknown. Here we show that mutations in the embryonic myosin heavy chain (MYH3) gene cause Freeman-Sheldon syndrome (FSS), one of the most severe multiple congenital contracture (that is, arthrogryposis) syndromes, and nearly one-...
journal_title:Nature genetics
pub_type: 杂志文章
doi:10.1038/ng1775
更新日期:2006-05-01 00:00:00
abstract::Trophoblast cells of the placenta are established at the blastocyst stage and differentiate into specialized subtypes after implantation. In mice, the outer layer of the placenta consists of trophoblast giant cells that invade the uterus and promote maternal blood flow to the implantation site by producing cytokines w...
journal_title:Nature genetics
pub_type: 杂志文章
doi:10.1038/77076
更新日期:2000-07-01 00:00:00
abstract::To compare lung adenocarcinoma (ADC) and lung squamous cell carcinoma (SqCC) and to identify new drivers of lung carcinogenesis, we examined the exome sequences and copy number profiles of 660 lung ADC and 484 lung SqCC tumor-normal pairs. Recurrent alterations in lung SqCCs were more similar to those of other squamou...
journal_title:Nature genetics
pub_type: 杂志文章
doi:10.1038/ng.3564
更新日期:2016-06-01 00:00:00
abstract::Motile cilia induce fluid movement through their rhythmic beating activity. In mammals, the transcription factor Foxj1 has been implicated in motile cilia formation. Here we show that a zebrafish Foxj1 homolog, foxj1a, is a target of Hedgehog signaling in the floor plate. Loss of Foxj1a compromises the assembly of mot...
journal_title:Nature genetics
pub_type: 杂志文章
doi:10.1038/ng.263
更新日期:2008-12-01 00:00:00