Abstract:
:c-Jun is a major component of the heterodimeric transcription factor AP-1 and is essential for embryonic development, as fetuses lacking Jun die at mid-gestation with impaired hepatogenesis and primary Jun-/- fibroblasts have a severe proliferation defect and undergo premature senescence in vitro. c-Jun and AP-1 activities are regulated by c-Jun N-terminal phosphorylation (JNP) at serines 63 and 73 through Jun N-terminal kinases(JNKs). JNP is thought to be required for the anti-apoptotic function of c-Jun during hepatogenesis, as mice lacking the JNK kinase SEK1 exhibit liver defects similar to those seen in Jun-/- fetuses. To investigate the physiological relevance of JNP, we replaced endogenous Jun by a mutant Jun allele with serines 63 and 73 mutated to alanines (Jun(tm1wag); hereafter referred to as JunAA). Here we show that primary JunAA fibroblasts have proliferation- and stress-induced apoptotic defects, accompanied by reduced AP-1 activity. JunAA mice are viable and fertile, smaller than controls and resistant to epileptic seizures and neuronal apoptosis induced by the excitatory amino acid kainate. Primary mutant neurons are also protected from apoptosis and exhibit unaltered JNK activity. Our results provide evidence that JNP is dispensable for mouse development, and identify c-Jun as the essential substrate of JNK signalling during kainate-induced neuronal apoptosis.
journal_name
Nat Genetjournal_title
Nature geneticsauthors
Behrens A,Sibilia M,Wagner EFdoi
10.1038/6854keywords:
subject
Has Abstractpub_date
1999-03-01 00:00:00pages
326-9issue
3eissn
1061-4036issn
1546-1718journal_volume
21pub_type
杂志文章相关文献
NATURE GENETICS文献大全abstract::Chronic pancreatitis (CP) is a continuing or relapsing inflammatory disease of the pancreas. In approximately one-third of all cases, no aetiological factor can be found, and these patients are classified as having idiopathic disease. Pathophysiologically, autodigestion and inflammation may be caused by either increas...
journal_title:Nature genetics
pub_type: 杂志文章
doi:10.1038/76088
更新日期:2000-06-01 00:00:00
abstract::Sequence variants affecting blood lipids and coronary artery disease (CAD) may enhance understanding of the atherogenicity of lipid fractions. Using a large resource of whole-genome sequence data, we examined rare and low-frequency variants for association with non-HDL cholesterol, HDL cholesterol, LDL cholesterol, an...
journal_title:Nature genetics
pub_type: 杂志文章
doi:10.1038/ng.3561
更新日期:2016-06-01 00:00:00
abstract::Retrotransposition affects genome structure by increasing repetition and producing insertional mutations. Dispersion of the retrotransposon L1 throughout mammalian genomes suggests that L1 activity might be an important evolutionary force. Here we report that L1 retrotransposition contributes to rapid genome evolution...
journal_title:Nature genetics
pub_type: 杂志文章
doi:10.1038/3104
更新日期:1998-11-01 00:00:00
abstract::In a recent genome-wide association study of generalized vitiligo, we identified ten confirmed susceptibility loci. By testing additional loci that showed suggestive association in the genome-wide study, using two replication cohorts of European descent, we observed replicated association of generalized vitiligo with ...
journal_title:Nature genetics
pub_type: 杂志文章,多中心研究
doi:10.1038/ng.602
更新日期:2010-07-01 00:00:00
abstract::Loss of tight association between epidermis and dermis underlies several blistering disorders and is frequently caused by impaired function of extracellular matrix (ECM) proteins. Here we describe a new protein in mouse, Fras1, that is specifically detected in a linear fashion underlying the epidermis and the basal su...
journal_title:Nature genetics
pub_type: 杂志文章
doi:10.1038/ng1168
更新日期:2003-06-01 00:00:00
abstract::Epilepsy affects at least 2% of the population at some time in their lives. The epilepsies are a heterogeneous group of disorders, many with an inherited component. Although specific genes have been identified in a few rare diseases causing seizures as part of a more diffuse brain disorder, the molecular pathology of ...
journal_title:Nature genetics
pub_type: 杂志文章
doi:10.1038/ng1095-201
更新日期:1995-10-01 00:00:00
abstract::Studying consanguineous families with Ghosal hematodiaphyseal dysplasia syndrome (GHDD), a disorder of increased bone density, we identified mutations in TBXAS1, which encodes thromboxane synthase (TXAS). TXAS, an enzyme of the arachidonic acid cascade, produces thromboxane A(2) (TXA(2)). Platelets from subjects with ...
journal_title:Nature genetics
pub_type: 杂志文章
doi:10.1038/ng.2007.66
更新日期:2008-03-01 00:00:00
abstract::A genome-wide association screen for primary biliary cirrhosis risk alleles was performed in an Italian cohort. The results from the Italian cohort replicated IL12A and IL12RB associations, and a combined meta-analysis using a Canadian dataset identified newly associated loci at SPIB (P = 7.9 x 10(-11), odds ratio (OR...
journal_title:Nature genetics
pub_type: 杂志文章
doi:10.1038/ng.627
更新日期:2010-08-01 00:00:00
abstract::Comparisons of chromosome X and the autosomes can illuminate differences in the histories of males and females as well as shed light on the forces of natural selection. We compared the patterns of variation in these parts of the genome using two datasets that we assembled for this study that are both genomic in scale....
journal_title:Nature genetics
pub_type: 杂志文章
doi:10.1038/ng.303
更新日期:2009-01-01 00:00:00
abstract::There is increasing evidence showing that the stromal cells surrounding cancer epithelial cells, rather than being passive bystanders, might have a role in modifying tumor outgrowth. The molecular basis of this aspect of carcinoma etiology is controversial. Some studies have reported a high frequency of genetic aberra...
journal_title:Nature genetics
pub_type: 杂志文章
doi:10.1038/ng.117
更新日期:2008-05-01 00:00:00
abstract::Joubert syndrome-related disorders (JSRD) are a group of syndromes sharing the neuroradiological features of cerebellar vermis hypoplasia and a peculiar brainstem malformation known as the 'molar tooth sign'. We identified mutations in the CEP290 gene in five families with variable neurological, retinal and renal mani...
journal_title:Nature genetics
pub_type: 杂志文章
doi:10.1038/ng1805
更新日期:2006-06-01 00:00:00
abstract::It is generally assumed that the male:female (M:F) ratio in patients with type 1 (insulin-dependent) diabetes mellitus (IDDM) is 1. A recent survey, however, revealed that high incidence countries (mainly European) have a high M:F ratio and low incidence ones (Asian and African) have a low M:F ratio. We have now analy...
journal_title:Nature genetics
pub_type: 杂志文章
doi:10.1038/995
更新日期:1998-07-01 00:00:00
abstract::Epileptic encephalopathies are severe brain disorders with the epileptic component contributing to the worsening of cognitive and behavioral manifestations. Acquired epileptic aphasia (Landau-Kleffner syndrome, LKS) and continuous spike and waves during slow-wave sleep syndrome (CSWSS) represent rare and closely relat...
journal_title:Nature genetics
pub_type: 杂志文章
doi:10.1038/ng.2726
更新日期:2013-09-01 00:00:00
abstract::Dentinogenesis imperfecta 1 (DGI1, MIM 125490) is an autosomal dominant dental disease characterized by abnormal dentin production and mineralization. The DGI1 locus was recently refined to a 2-Mb interval on 4q21 (ref. 1). Here we study three Chinese families carrying DGI1. We find that the affected individuals of tw...
journal_title:Nature genetics
pub_type: 杂志文章
doi:10.1038/84848
更新日期:2001-02-01 00:00:00
abstract::Current efforts in cellular disease modeling and regenerative medicine are limited by the paucity of cell types that can be generated in the laboratory. A new study introduces a computational framework, Mogrify, that uses network biology to predict combinations of transcription factors necessary for direct conversion ...
journal_title:Nature genetics
pub_type: 评论,新闻
doi:10.1038/ng.3516
更新日期:2016-03-01 00:00:00
abstract::Crosses between the two North American rodent species Peromyscus polionotus (PO) and Peromyscus maniculatus (BW) yield parent-of-origin effects on both embryonic and placental growth. The two species are approximately the same size, but a female BW crossed with a male PO produces offspring that are smaller than either...
journal_title:Nature genetics
pub_type: 杂志文章
doi:10.1038/75518
更新日期:2000-05-01 00:00:00
abstract::Therapeutic cloning, whereby somatic cell nuclear transfer (SCNT) is used to generate patient-specific embryonic stem cells (ESCs) from blastocysts cloned by nuclear transfer (ntESCs), holds great promise for the treatment of many human diseases. ntESCs have been derived in mice and cattle, but thus far there are no c...
journal_title:Nature genetics
pub_type: 杂志文章,评审
doi:10.1038/ng1973
更新日期:2007-03-01 00:00:00
abstract::The cardiac homeobox protein Nkx2-5 is essential in cardiac development, and mutations in Csx (which encodes Nkx2-5) cause various congenital heart diseases. Using the yeast two-hybrid system with Nkx2-5 as the 'bait', we isolated the T-box-containing transcription factor Tbx5; mutations in TBX5 cause heart and limb m...
journal_title:Nature genetics
pub_type: 杂志文章
doi:10.1038/90123
更新日期:2001-07-01 00:00:00
abstract::Legionella pneumophila, the causative agent of Legionnaires' disease, replicates as an intracellular parasite of amoebae and persists in the environment as a free-living microbe. Here we have analyzed the complete genome sequences of L. pneumophila Paris (3,503,610 bp, 3,077 genes), an endemic strain that is predomina...
journal_title:Nature genetics
pub_type: 杂志文章
doi:10.1038/ng1447
更新日期:2004-11-01 00:00:00
abstract::A CRISPR screen conducted in a CD4+ T cell leukemia line has identified host factors required for HIV infection but dispensable for cellular survival. The results highlight sulfation on the HIV co-receptor CCR5 and cellular aggregation as potential targets for therapeutic intervention. ...
journal_title:Nature genetics
pub_type: 杂志文章
doi:10.1038/ng.3777
更新日期:2017-01-31 00:00:00
abstract::Genetic studies of complex traits have mainly identified associations with noncoding variants. To further determine the contribution of regulatory variation, we combined whole-genome and transcriptome data for 624 individuals from Sardinia to identify common and rare variants that influence gene expression and splicin...
journal_title:Nature genetics
pub_type: 杂志文章
doi:10.1038/ng.3840
更新日期:2017-05-01 00:00:00
abstract::Bardet-Biedl syndrome (BBS, MIM 209900) is a heterogeneous autosomal recessive disorder characterized by obesity, pigmentary retinopathy, polydactyly, renal malformations, mental retardation, and hypogenitalism. The disorder is also associated with diabetes mellitus, hypertension, and congenital heart disease. Six dis...
journal_title:Nature genetics
pub_type: 杂志文章
doi:10.1038/88925
更新日期:2001-06-01 00:00:00
abstract::Schwartz-Jampel syndrome (SJS1) is a rare autosomal recessive disorder characterized by permanent myotonia (prolonged failure of muscle relaxation) and skeletal dysplasia, resulting in reduced stature, kyphoscoliosis, bowing of the diaphyses and irregular epiphyses. Electromyographic investigations reveal repetitive m...
journal_title:Nature genetics
pub_type: 杂志文章
doi:10.1038/82638
更新日期:2000-12-01 00:00:00
abstract::Intestinal microbiota is known to be important in health and disease. Its composition is influenced by both environmental and host factors. Few large-scale studies have evaluated the association between host genetic variation and the composition of microbiota. We recruited a cohort of 1,561 healthy individuals, of who...
journal_title:Nature genetics
pub_type: 杂志文章
doi:10.1038/ng.3693
更新日期:2016-11-01 00:00:00
abstract::Enterotoxigenic Escherichia coli (ETEC), a major cause of infectious diarrhea, produce heat-stable and/or heat-labile enterotoxins and at least 25 different colonization factors that target the intestinal mucosa. The genes encoding the enterotoxins and most of the colonization factors are located on plasmids found acr...
journal_title:Nature genetics
pub_type: 杂志文章
doi:10.1038/ng.3145
更新日期:2014-12-01 00:00:00
abstract::The breast cancer risk variants identified in genome-wide association studies explain only a small fraction of the familial relative risk, and the genes responsible for these associations remain largely unknown. To identify novel risk loci and likely causal genes, we performed a transcriptome-wide association study ev...
journal_title:Nature genetics
pub_type: 杂志文章
doi:10.1038/s41588-018-0132-x
更新日期:2018-07-01 00:00:00
abstract::Genetic robustness characterizes the constancy of the phenotype in face of heritable perturbations. Previous investigations have used comprehensive single and double gene knockouts to study gene essentiality and pairwise gene interactions in the yeast Saccharomyces cerevisiae. Here we conduct an in silico multiple kno...
journal_title:Nature genetics
pub_type: 杂志文章
doi:10.1038/ng1856
更新日期:2006-09-01 00:00:00
abstract::Lafora's disease (LD; OMIM 254780) is an autosomal recessive form of progressive myoclonus epilepsy characterized by seizures and cumulative neurological deterioration. Onset occurs during late childhood and usually results in death within ten years of the first symptoms. With few exceptions, patients follow a homogen...
journal_title:Nature genetics
pub_type: 杂志文章
doi:10.1038/2470
更新日期:1998-10-01 00:00:00
abstract::Obesity results from the interaction of genetic and environmental factors. To search for sequence variants that affect variation in two common measures of obesity, weight and body mass index (BMI), both of which are highly heritable, we performed a genome-wide association (GWA) study with 305,846 SNPs typed in 25,344 ...
journal_title:Nature genetics
pub_type: 杂志文章
doi:10.1038/ng.274
更新日期:2009-01-01 00:00:00
abstract::The homeodomain protein IPF1 (also known as IDX1, STF1 and PDX1; see Methods) is critical for development of the pancreas in mice and is a key factor for the regulation of the insulin gene in the beta-cells of the endocrine pancreas. Targeted disruption of the Ipf1 gene encoding IPF1 in transgenic mice results in a fa...
journal_title:Nature genetics
pub_type: 杂志文章
doi:10.1038/ng0197-106
更新日期:1997-01-01 00:00:00