Genome-wide meta-analyses identify three loci associated with primary biliary cirrhosis.

Abstract:

:A genome-wide association screen for primary biliary cirrhosis risk alleles was performed in an Italian cohort. The results from the Italian cohort replicated IL12A and IL12RB associations, and a combined meta-analysis using a Canadian dataset identified newly associated loci at SPIB (P = 7.9 x 10(-11), odds ratio (OR) = 1.46), IRF5-TNPO3 (P = 2.8 x 10(-10), OR = 1.63) and 17q12-21 (P = 1.7 x 10(-10), OR = 1.38).

journal_name

Nat Genet

journal_title

Nature genetics

authors

Liu X,Invernizzi P,Lu Y,Kosoy R,Lu Y,Bianchi I,Podda M,Xu C,Xie G,Macciardi F,Selmi C,Lupoli S,Shigeta R,Ransom M,Lleo A,Lee AT,Mason AL,Myers RP,Peltekian KM,Ghent CN,Bernuzzi F,Zuin M,Rosina F,Borghesio E

doi

10.1038/ng.627

subject

Has Abstract

pub_date

2010-08-01 00:00:00

pages

658-60

issue

8

eissn

1061-4036

issn

1546-1718

pii

ng.627

journal_volume

42

pub_type

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