Abstract:
:Accumulation of genetic incompatibilities within species can lead to reproductive isolation and, potentially, speciation. In this study, we show that allelic variation at SRF3 (Strubbelig Receptor Family 3), encoding a receptor-like kinase, conditions the occurrence of incompatibility between Arabidopsis thaliana accessions. The geographical distribution of SRF3 alleles reveals that allelic forms causing epistatic incompatibility with a Landsberg erecta allele at the RPP1 resistance locus are present in A. thaliana accessions in central Asia. Incompatible SRF3 alleles condition for an enhanced early immune response to pathogens as compared to the resistance-dampening effect of compatible SRF3 forms in isogenic backgrounds. Variation in disease susceptibility suggests a basis for the molecular patterns of a recent selective sweep detected at the SRF3 locus in central Asian populations.
journal_name
Nat Genetjournal_title
Nature geneticsauthors
Alcázar R,García AV,Kronholm I,de Meaux J,Koornneef M,Parker JE,Reymond Mdoi
10.1038/ng.704subject
Has Abstractpub_date
2010-12-01 00:00:00pages
1135-9issue
12eissn
1061-4036issn
1546-1718pii
ng.704journal_volume
42pub_type
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