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X-chromosome inactivation occurs at different times in different tissues of the post-implantation mouse embryo.

Abstract：

:During mammalian development, one of the two X chromosomes in female embryos is randomly inactivated in the somatic cell in order to achieve gene dosage compensation. But is X inactivation established simultaneously or is it accomplished over time in a lineage-dependent fashion? We have examined this question in mouse embryos carrying an X-linked lacZ transgene. This transgene is subject to inactivation and the loss of beta-galactosidase activity provides a direct indication of X inactivation in individual cells. We find that X inactivation proceeds with different schedules in different somatic tissues, and the notochord, the heart, cranial mesoderm and the hindgut are among the last tissues to undergo X inactivation.

journal_name

Nat Genet

journal_title

Nature genetics

authors

Tan SS,Williams EA,Tam PP

doi

10.1038/ng0293-170

subject

Has Abstract

pub_date

1993-02-01 00:00:00

pages

170-4

issue

2

eissn

1061-4036

issn

1546-1718

journal_volume

3

pub_type

杂志文章

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