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Untangling the genetics from the epigenetics in pancreatic cancer metastasis.

Abstract：

:Comparative genomic analyses of primary tumors and metastases within individuals with pancreatic cancer have exposed the complex clonal dynamics that underlie the dissemination of cancer cells to distant sites. Recent studies implicate non-genetic mechanisms in this process, particularly fluctuations in chromatin states and metabolism, which can endow rare cells within a primary tumor with metastatic potential.

journal_name

Nat Genet

journal_title

Nature genetics

authors

Vakoc CR,Tuveson DA

doi

10.1038/ng.3798

subject

Has Abstract

pub_date

2017-02-24 00:00:00

pages

323-324

issue

3

eissn

1061-4036

issn

1546-1718

pii

ng.3798

journal_volume

49

pub_type

杂志文章

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