Abstract:
:Pioneer transcription factors establish new cell-fate competence by triggering chromatin remodeling. However, many features of pioneer action, such as their kinetics and stability, remain poorly defined. Here, we show that Pax7, by opening a unique repertoire of enhancers, is necessary and sufficient for specification of one pituitary lineage. Pax7 binds its targeted enhancers rapidly, but chromatin remodeling and gene activation are slower. Enhancers opened by Pax7 show a loss of DNA methylation and acquire stable epigenetic memory, as evidenced by binding of nonpioneer factors after Pax7 withdrawal. This work shows that transient Pax7 expression is sufficient for stable specification of cell identity.
journal_name
Nat Genetjournal_title
Nature geneticsauthors
Mayran A,Khetchoumian K,Hariri F,Pastinen T,Gauthier Y,Balsalobre A,Drouin Jdoi
10.1038/s41588-017-0035-2subject
Has Abstractpub_date
2018-02-01 00:00:00pages
259-269issue
2eissn
1061-4036issn
1546-1718pii
10.1038/s41588-017-0035-2journal_volume
50pub_type
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