当前位置： SCI文献检索 > NATURE GENETICS期刊下所有文献 > Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease.

Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease.

Abstract：

:We sought to identify new susceptibility loci for Alzheimer's disease through a staged association study (GERAD+) and by testing suggestive loci reported by the Alzheimer's Disease Genetic Consortium (ADGC) in a companion paper. We undertook a combined analysis of four genome-wide association datasets (stage 1) and identified ten newly associated variants with P ≤ 1 × 10(-5). We tested these variants for association in an independent sample (stage 2). Three SNPs at two loci replicated and showed evidence for association in a further sample (stage 3). Meta-analyses of all data provided compelling evidence that ABCA7 (rs3764650, meta P = 4.5 × 10(-17); including ADGC data, meta P = 5.0 × 10(-21)) and the MS4A gene cluster (rs610932, meta P = 1.8 × 10(-14); including ADGC data, meta P = 1.2 × 10(-16)) are new Alzheimer's disease susceptibility loci. We also found independent evidence for association for three loci reported by the ADGC, which, when combined, showed genome-wide significance: CD2AP (GERAD+, P = 8.0 × 10(-4); including ADGC data, meta P = 8.6 × 10(-9)), CD33 (GERAD+, P = 2.2 × 10(-4); including ADGC data, meta P = 1.6 × 10(-9)) and EPHA1 (GERAD+, P = 3.4 × 10(-4); including ADGC data, meta P = 6.0 × 10(-10)).

journal_name

Nat Genet

journal_title

Nature genetics

authors

Hollingworth P,Harold D,Sims R,Gerrish A,Lambert JC,Carrasquillo MM,Abraham R,Hamshere ML,Pahwa JS,Moskvina V,Dowzell K,Jones N,Stretton A,Thomas C,Richards A,Ivanov D,Widdowson C,Chapman J,Lovestone S,Powell J,Pr

doi

10.1038/ng.803

subject

Has Abstract

pub_date

2011-05-01 00:00:00

pages

429-35

issue

5

eissn

1061-4036

issn

1546-1718

pii

ng.803

journal_volume

43

pub_type

杂志文章,meta分析

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