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A double-stranded RNA binding protein required for activation of repressed messages in mammalian germ cells.

Abstract：

:Chromatin packaging in mammalian spermatozoa requires an ordered replacement of the somatic histones by two classes of spermatid-specific basic proteins, the transition proteins and the protamines. Temporal expression of transition proteins and protamines during spermatid differentiation is under translational control, and premature translation of protamine 1 leads to precocious nuclear condensation and sterility. We have previously suggested that the double-stranded (ds) RNA binding protein Prbp (encoded by the gene Tarbp2) functions as a translational regulator during mouse spermatogenesis. Here we show that Prbp is required for proper translational activation of the mRNAs encoding the protamines. We generated mice that carry a targeted disruption of Tarbp2 and determined that they were sterile and severely oligospermic. Using immunohistological analysis, we determined that the endogenous Prm2 mRNA and a reporter mRNA carrying protamine 1 translational-control elements were translated in a mosaic pattern. We showed that failure to synthesize the protamines resulted in delayed replacement of the transition proteins and subsequent failure of spermiation. The timing of Prbp expression suggests that it may function as a chaperone in the assembly of specific translationally regulated ribonucleoprotein particles.

journal_name

Nat Genet

journal_title

Nature genetics

authors

Zhong J,Peters AH,Lee K,Braun RE

doi

10.1038/9684

keywords:

subject

Has Abstract

pub_date

1999-06-01 00:00:00

pages

171-4

issue

2

eissn

1061-4036

issn

1546-1718

journal_volume

22

pub_type

杂志文章

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