Abstract:
:Recovery from blood loss requires a greatly enhanced supply of iron to support expanded erythropoiesis. After hemorrhage, suppression of the iron-regulatory hormone hepcidin allows increased iron absorption and mobilization from stores. We identified a new hormone, erythroferrone (ERFE), that mediates hepcidin suppression during stress erythropoiesis. ERFE is produced by erythroblasts in response to erythropoietin. ERFE-deficient mice fail to suppress hepcidin rapidly after hemorrhage and exhibit a delay in recovery from blood loss. ERFE expression is greatly increased in Hbb(th3/+) mice with thalassemia intermedia, where it contributes to the suppression of hepcidin and the systemic iron overload characteristic of this disease.
journal_name
Nat Genetjournal_title
Nature geneticsauthors
Kautz L,Jung G,Valore EV,Rivella S,Nemeth E,Ganz Tdoi
10.1038/ng.2996subject
Has Abstractpub_date
2014-07-01 00:00:00pages
678-84issue
7eissn
1061-4036issn
1546-1718pii
ng.2996journal_volume
46pub_type
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