Identification of erythroferrone as an erythroid regulator of iron metabolism.

Abstract:

:Recovery from blood loss requires a greatly enhanced supply of iron to support expanded erythropoiesis. After hemorrhage, suppression of the iron-regulatory hormone hepcidin allows increased iron absorption and mobilization from stores. We identified a new hormone, erythroferrone (ERFE), that mediates hepcidin suppression during stress erythropoiesis. ERFE is produced by erythroblasts in response to erythropoietin. ERFE-deficient mice fail to suppress hepcidin rapidly after hemorrhage and exhibit a delay in recovery from blood loss. ERFE expression is greatly increased in Hbb(th3/+) mice with thalassemia intermedia, where it contributes to the suppression of hepcidin and the systemic iron overload characteristic of this disease.

journal_name

Nat Genet

journal_title

Nature genetics

authors

Kautz L,Jung G,Valore EV,Rivella S,Nemeth E,Ganz T

doi

10.1038/ng.2996

subject

Has Abstract

pub_date

2014-07-01 00:00:00

pages

678-84

issue

7

eissn

1061-4036

issn

1546-1718

pii

ng.2996

journal_volume

46

pub_type

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