Xlr3b is a new imprinted candidate for X-linked parent-of-origin effects on cognitive function in mice.

Abstract:

:Imprinted genes show differential expression between maternal and paternal alleles as a consequence of epigenetic modification that can result in 'parent-of-origin' effects on phenotypic traits. There is increasing evidence from mouse and human studies that imprinted genes may influence behavior and cognitive functioning. Previous work in girls with Turner syndrome (45,XO) has suggested that there are X-linked parent-of-origin effects on brain development and cognitive functioning, although the interpretation of these data in terms of imprinted gene effects has been questioned. We used a 39,XO mouse model to examine the influence of the parental origin of the X chromosome on cognitive behaviors and expression of X-linked genes in brain. Our findings confirm the existence of X-linked imprinted effects on cognitive processes and identify a new maternally expressed imprinted gene candidate on the X chromosome, Xlr3b, which may be of importance in mediating the behavioral effects.

journal_name

Nat Genet

journal_title

Nature genetics

authors

Davies W,Isles A,Smith R,Karunadasa D,Burrmann D,Humby T,Ojarikre O,Biggin C,Skuse D,Burgoyne P,Wilkinson L

doi

10.1038/ng1577

keywords:

subject

Has Abstract

pub_date

2005-06-01 00:00:00

pages

625-9

issue

6

eissn

1061-4036

issn

1546-1718

pii

ng1577

journal_volume

37

pub_type

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