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A single-nucleotide polymorphism tagging set for human drug metabolism and transport.

Abstract：

:Interindividual variability in drug response, ranging from no therapeutic benefit to life-threatening adverse reactions, is influenced by variation in genes that control the absorption, distribution, metabolism and excretion of drugs. We genotyped 904 single-nucleotide polymorphisms (SNPs) from 55 such genes in two population samples (European and Japanese) and identified a set of tagging SNPs that represents the common variation in these genes, both known and unknown. Extensive empirical evaluations, including a direct assessment of association with candidate functional SNPs in a new, larger population sample, validated the performance of these tagging SNPs and confirmed their utility for linkage-disequilibrium mapping in pharmacogenetics. The analyses also suggest that rare variation is not amenable to tagging strategies.

journal_name

Nat Genet

journal_title

Nature genetics

authors

Ahmadi KR,Weale ME,Xue ZY,Soranzo N,Yarnall DP,Briley JD,Maruyama Y,Kobayashi M,Wood NW,Spurr NK,Burns DK,Roses AD,Saunders AM,Goldstein DB

doi

10.1038/ng1488

keywords:

subject

Has Abstract

pub_date

2005-01-01 00:00:00

pages

84-9

issue

1

eissn

1061-4036

issn

1546-1718

pii

ng1488

journal_volume

37

pub_type

杂志文章

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