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Biological and biomedical implications of the co-evolution of pathogens and their hosts.

Abstract：

:Co-evolution between host and pathogen is, in principle, a powerful determinant of the biology and genetics of infection and disease. Yet co-evolution has proven difficult to demonstrate rigorously in practice, and co-evolutionary thinking is only just beginning to inform medical or veterinary research in any meaningful way, even though it can have a major influence on how genetic variation in biomedically important traits is interpreted. Improving our understanding of the biomedical significance of co-evolution will require changing the way in which we look for it, complementing the phenomenological approach traditionally favored by evolutionary biologists with the exploitation of the extensive data becoming available on the molecular biology and molecular genetics of host-pathogen interactions.

journal_name

Nat Genet

journal_title

Nature genetics

authors

Woolhouse ME,Webster JP,Domingo E,Charlesworth B,Levin BR

doi

10.1038/ng1202-569

keywords:

subject

Has Abstract

pub_date

2002-12-01 00:00:00

pages

569-77

issue

4

eissn

1061-4036

issn

1546-1718

pii

ng1202-569

journal_volume

32

pub_type

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