Abstract:
:Congenic breeding strategies are becoming increasingly important as a greater number of complex trait linkages are identified. Traditionally, the development of a congenic strain has been a time-consuming endeavour, requiring ten generations of backcrosses. The recent advent of a dense molecular genetic map of the mouse permits methods that can reduce the time needed for congenic-strain production by 18-24 months. We present a theoretical evaluation of marker-assisted congenic production and provide the empirical data that support it. We present this 'speed congenic' method in a user-friendly manner to encourage other investigators to pursue this or similar methods of congenic production.
journal_name
Nat Genetjournal_title
Nature geneticsauthors
Markel P,Shu P,Ebeling C,Carlson GA,Nagle DL,Smutko JS,Moore KJdoi
10.1038/ng1197-280subject
Has Abstractpub_date
1997-11-01 00:00:00pages
280-4issue
3eissn
1061-4036issn
1546-1718journal_volume
17pub_type
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