当前位置： SCI文献检索 > NATURE GENETICS期刊下所有文献 > Distinct in vivo requirements for establishment versus maintenance of transcriptional repression.

Distinct in vivo requirements for establishment versus maintenance of transcriptional repression.

Abstract：

:Low-level ectopic expression of the Runt transcription factor blocks activation of the Drosophila melanogaster segmentation gene engrailed (en) in odd-numbered parasegments and is associated with a lethal phenotype. Here we show, by using a genetic screen for maternal factors that contribute in a dose-dependent fashion to Runt-mediated repression, that there are two distinct steps in the repression of en by Runt. The initial establishment of repression is sensitive to the dosage of the zinc-finger transcription factor Tramtrack. By contrast, the co-repressor proteins Groucho and dCtBP, and the histone deacetylase Rpd3, do not affect establishment but instead maintain repression after the blastoderm stage. The distinction between establishment and maintenance is confirmed by experiments with Runt derivatives that are impaired specifically for either co-repressor interaction or DNA binding. Other transcription factors can also establish repression in Rpd3-deficient embryos, which indicates that the distinction between establishment and maintenance may be a general feature of eukaryotic transcriptional repression.

journal_name

Nat Genet

journal_title

Nature genetics

authors

Wheeler JC,VanderZwan C,Xu X,Swantek D,Tracey WD,Gergen JP

doi

10.1038/ng942

keywords:

subject

Has Abstract

pub_date

2002-09-01 00:00:00

pages

206-10

issue

1

eissn

1061-4036

issn

1546-1718

pii

ng942

journal_volume

32

pub_type

杂志文章

相关文献

NATURE GENETICS文献大全
  • Specific interaction between genotype, smoking and autoimmunity to citrullinated alpha-enolase in the etiology of rheumatoid arthritis.

    abstract：:Gene-environment associations are important in rheumatoid arthritis (RA) susceptibility, with an association existing between smoking, HLA- DRB1 'shared epitope' alleles, PTPN22 and antibodies to cyclic citrullinated peptides (CCP). Here, we test the hypothesis that a subset of the anti-CCP response, with specific aut...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng.480

    authors： Mahdi H,Fisher BA,Källberg H,Plant D,Malmström V,Rönnelid J,Charles P,Ding B,Alfredsson L,Padyukov L,Symmons DP,Venables PJ,Klareskog L,Lundberg K

    更新日期：2009-12-01 00:00:00

  • Convergent evolution of the genomes of marine mammals.

    abstract：:Marine mammals from different mammalian orders share several phenotypic traits adapted to the aquatic environment and therefore represent a classic example of convergent evolution. To investigate convergent evolution at the genomic level, we sequenced and performed de novo assembly of the genomes of three species of m...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng.3198

    authors： Foote AD,Liu Y,Thomas GW,Vinař T,Alföldi J,Deng J,Dugan S,van Elk CE,Hunter ME,Joshi V,Khan Z,Kovar C,Lee SL,Lindblad-Toh K,Mancia A,Nielsen R,Qin X,Qu J,Raney BJ,Vijay N,Wolf JB,Hahn MW,Muzny DM,Worley KC,

    更新日期：2015-03-01 00:00:00

  • Common variants at 11p13 are associated with susceptibility to tuberculosis.

    abstract：:After imputation of data from the 1000 Genomes Project into a genome-wide dataset of Ghanaian individuals with tuberculosis and controls, we identified a resistance locus on chromosome 11p13 downstream of the WT1 gene (encoding Wilms tumor 1). The strongest signal was obtained at the rs2057178 SNP (P = 2.63 × 10(-9))....

    journal_title：Nature genetics

    pub_type： 杂志文章,meta分析

    doi：10.1038/ng.1080

    authors： Thye T,Owusu-Dabo E,Vannberg FO,van Crevel R,Curtis J,Sahiratmadja E,Balabanova Y,Ehmen C,Muntau B,Ruge G,Sievertsen J,Gyapong J,Nikolayevskyy V,Hill PC,Sirugo G,Drobniewski F,van de Vosse E,Newport M,Alisjahbana B,

    更新日期：2012-02-05 00:00:00

  • Cadmium is a mutagen that acts by inhibiting mismatch repair.

    abstract：:Most errors that arise during DNA replication can be corrected by DNA polymerase proofreading or by post-replication mismatch repair (MMR). Inactivation of both mutation-avoidance systems results in extremely high mutability that can lead to error catastrophe. High mutability and the likelihood of cancer can be caused...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng1172

    authors： Jin YH,Clark AB,Slebos RJ,Al-Refai H,Taylor JA,Kunkel TA,Resnick MA,Gordenin DA

    更新日期：2003-07-01 00:00:00

  • Mutation of NLRC4 causes a syndrome of enterocolitis and autoinflammation.

    abstract：:Upon detection of pathogen-associated molecular patterns, innate immune receptors initiate inflammatory responses. These receptors include cytoplasmic NOD-like receptors (NLRs) whose stimulation recruits and proteolytically activates caspase-1 within the inflammasome, a multiprotein complex. Caspase-1 mediates the pro...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng.3066

    authors： Romberg N,Al Moussawi K,Nelson-Williams C,Stiegler AL,Loring E,Choi M,Overton J,Meffre E,Khokha MK,Huttner AJ,West B,Podoltsev NA,Boggon TJ,Kazmierczak BI,Lifton RP

    更新日期：2014-10-01 00:00:00

  • A murine model of Menkes disease reveals a physiological function of metallothionein.

    abstract：:Human Menkes disease and the murine Mottled phenotype are X-linked diseases that result from copper deficiency due to mutations in a copper-effluxing ATPase, designated ATP7A. Male mice with the Mottled-Brindled allele (Mo-brJ) accumulate copper in the intestine, fail to export copper to peripheral organs and die a fe...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng0696-219

    authors： Kelly EJ,Palmiter RD

    更新日期：1996-06-01 00:00:00

  • Loss-of-function mutations in FGFR1 cause autosomal dominant Kallmann syndrome.

    abstract：:We took advantage of overlapping interstitial deletions at chromosome 8p11-p12 in two individuals with contiguous gene syndromes and defined an interval of roughly 540 kb associated with a dominant form of Kallmann syndrome, KAL2. We establish here that loss-of-function mutations in FGFR1 underlie KAL2 whereas a gain-...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng1122

    authors： Dodé C,Levilliers J,Dupont JM,De Paepe A,Le Dû N,Soussi-Yanicostas N,Coimbra RS,Delmaghani S,Compain-Nouaille S,Baverel F,Pêcheux C,Le Tessier D,Cruaud C,Delpech M,Speleman F,Vermeulen S,Amalfitano A,Bachelot Y,Boucha

    更新日期：2003-04-01 00:00:00

  • Recessive mutations in the gene encoding the tubby-like protein TULP1 in patients with retinitis pigmentosa.

    abstract：:A recessive mutation in the tub gene causes obesity, deafness and retinal degeneration in tubby mice. The tub gene is a member of a family of tubby-like genes (TULPs) that encode proteins of unknown function. Members of this family have been identified in plants, vertebrates and invertebrates. The TULP proteins share ...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng0298-174

    authors： Hagstrom SA,North MA,Nishina PL,Berson EL,Dryja TP

    更新日期：1998-02-01 00:00:00

  • Integration of summary data from GWAS and eQTL studies predicts complex trait gene targets.

    abstract：:Genome-wide association studies (GWAS) have identified thousands of genetic variants associated with human complex traits. However, the genes or functional DNA elements through which these variants exert their effects on the traits are often unknown. We propose a method (called SMR) that integrates summary-level data ...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng.3538

    authors： Zhu Z,Zhang F,Hu H,Bakshi A,Robinson MR,Powell JE,Montgomery GW,Goddard ME,Wray NR,Visscher PM,Yang J

    更新日期：2016-05-01 00:00:00

  • Epilepsy and brain abnormalities in mice lacking the Otx1 gene.

    abstract：:The morphogenesis of the brain and the differentiation of the neural structures are highly complex processes. A series of temporally and spatially regulated morphogenetic events gives rise to smaller areas that are phylogenetically, functionally and often morphogenetically different. Candidate genes for positional inf...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng1096-218

    authors： Acampora D,Mazan S,Avantaggiato V,Barone P,Tuorto F,Lallemand Y,Brûlet P,Simeone A

    更新日期：1996-10-01 00:00:00

  • De novo deletions of SNRPN exon 1 in early human and mouse embryos result in a paternal to maternal imprint switch.

    abstract：:Prader-Willi syndrome (PWS) is a neurogenetic disease characterized by infantile hypotonia, gonadal hypoplasia, obsessive behaviour and neonatal feeding difficulties followed by hyperphagia, leading to profound obesity. PWS is due to a lack of paternal genetic information at 15q11-q13 (ref. 2). Five imprinted, paterna...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/75629

    authors： Bielinska B,Blaydes SM,Buiting K,Yang T,Krajewska-Walasek M,Horsthemke B,Brannan CI

    更新日期：2000-05-01 00:00:00

  • Germline mutations affecting the proofreading domains of POLE and POLD1 predispose to colorectal adenomas and carcinomas.

    abstract：:Many individuals with multiple or large colorectal adenomas or early-onset colorectal cancer (CRC) have no detectable germline mutations in the known cancer predisposition genes. Using whole-genome sequencing, supplemented by linkage and association analysis, we identified specific heterozygous POLE or POLD1 germline ...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng.2503

    authors： Palles C,Cazier JB,Howarth KM,Domingo E,Jones AM,Broderick P,Kemp Z,Spain SL,Guarino E,Salguero I,Sherborne A,Chubb D,Carvajal-Carmona LG,Ma Y,Kaur K,Dobbins S,Barclay E,Gorman M,Martin L,Kovac MB,Humphray S,COR

    更新日期：2013-02-01 00:00:00

  • Understanding multicellular function and disease with human tissue-specific networks.

    abstract：:Tissue and cell-type identity lie at the core of human physiology and disease. Understanding the genetic underpinnings of complex tissues and individual cell lineages is crucial for developing improved diagnostics and therapeutics. We present genome-wide functional interaction networks for 144 human tissues and cell t...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng.3259

    authors： Greene CS,Krishnan A,Wong AK,Ricciotti E,Zelaya RA,Himmelstein DS,Zhang R,Hartmann BM,Zaslavsky E,Sealfon SC,Chasman DI,FitzGerald GA,Dolinski K,Grosser T,Troyanskaya OG

    更新日期：2015-06-01 00:00:00

  • Transferrin receptor is necessary for development of erythrocytes and the nervous system.

    abstract：:Plasma iron circulates bound to transferrin (Trf), which solubilizes the ferric ion and attenuates its reactivity. Diferric Trf interacts with cell-surface Trf receptor (Trfr) to undergo receptor-mediated endocytosis into specialized endosomes. Endosomal acidification leads to iron release, and iron is transported out...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/7727

    authors： Levy JE,Jin O,Fujiwara Y,Kuo F,Andrews NC

    更新日期：1999-04-01 00:00:00

  • A Y-encoded subunit of the translation initiation factor Eif2 is essential for mouse spermatogenesis.

    abstract：:In mouse and man, deletions of specific regions of the Y chromosome have been linked to early failure of spermatogenesis and consequent sterility; the Y chromosomal gene(s) with this essential early role in spermatogenesis have not been identified. The partial deletion of the mouse Y short arm (the Sxrb deletion) that...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng717

    authors： Mazeyrat S,Saut N,Grigoriev V,Mahadevaiah SK,Ojarikre OA,Rattigan A,Bishop C,Eicher EM,Mitchell MJ,Burgoyne PS

    更新日期：2001-09-01 00:00:00

  • Large-scale analysis of the regulatory architecture of the mouse genome with a transposon-associated sensor.

    abstract：:We present here a Sleeping Beauty-based transposition system that offers a simple and efficient way to investigate the regulatory architecture of mammalian chromosomes in vivo. With this system, we generated several hundred mice and embryos, each with a regulatory sensor inserted at a random genomic position. This lar...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng.790

    authors： Ruf S,Symmons O,Uslu VV,Dolle D,Hot C,Ettwiller L,Spitz F

    更新日期：2011-03-20 00:00:00

  • G protein-coupled receptor P2Y5 and its ligand LPA are involved in maintenance of human hair growth.

    abstract：:Hypotrichosis simplex is a group of nonsyndromic human alopecias. We mapped an autosomal recessive form of this disorder to chromosome 13q14.11-13q21.33, and identified homozygous truncating mutations in P2RY5, which encodes an orphan G protein-coupled receptor. Furthermore, we identified oleoyl-L-alpha-lysophosphatid...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng.84

    authors： Pasternack SM,von Kügelgen I,Al Aboud K,Lee YA,Rüschendorf F,Voss K,Hillmer AM,Molderings GJ,Franz T,Ramirez A,Nürnberg P,Nöthen MM,Betz RC

    更新日期：2008-03-01 00:00:00

  • The genomic landscape of balanced cytogenetic abnormalities associated with human congenital anomalies.

    abstract：:Despite the clinical significance of balanced chromosomal abnormalities (BCAs), their characterization has largely been restricted to cytogenetic resolution. We explored the landscape of BCAs at nucleotide resolution in 273 subjects with a spectrum of congenital anomalies. Whole-genome sequencing revised 93% of karyot...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng.3720

    authors： Redin C,Brand H,Collins RL,Kammin T,Mitchell E,Hodge JC,Hanscom C,Pillalamarri V,Seabra CM,Abbott MA,Abdul-Rahman OA,Aberg E,Adley R,Alcaraz-Estrada SL,Alkuraya FS,An Y,Anderson MA,Antolik C,Anyane-Yeboa K,Atkin JF

    更新日期：2017-01-01 00:00:00

  • A mouse model for spinal muscular atrophy.

    abstract：:The survival motor neuron gene is present in humans in a telomeric copy, SMN1, and several centromeric copies, SMN2. Homozygous mutation of SMN1 is associated with proximal spinal muscular atrophy (SMA), a severe motor neuron disease characterized by early childhood onset of progressive muscle weakness. To understand ...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/71709

    authors： Hsieh-Li HM,Chang JG,Jong YJ,Wu MH,Wang NM,Tsai CH,Li H

    更新日期：2000-01-01 00:00:00

  • Haplotype-resolved genome analyses of a heterozygous diploid potato.

    abstract：:Potato (Solanum tuberosum L.) is the most important tuber crop worldwide. Efforts are underway to transform the crop from a clonally propagated tetraploid into a seed-propagated, inbred-line-based hybrid, but this process requires a better understanding of potato genome. Here, we report the 1.67-Gb haplotype-resolved ...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/s41588-020-0699-x

    authors： Zhou Q,Tang D,Huang W,Yang Z,Zhang Y,Hamilton JP,Visser RGF,Bachem CWB,Robin Buell C,Zhang Z,Zhang C,Huang S

    更新日期：2020-10-01 00:00:00

  • Evidence in the Legionella pneumophila genome for exploitation of host cell functions and high genome plasticity.

    abstract：:Legionella pneumophila, the causative agent of Legionnaires' disease, replicates as an intracellular parasite of amoebae and persists in the environment as a free-living microbe. Here we have analyzed the complete genome sequences of L. pneumophila Paris (3,503,610 bp, 3,077 genes), an endemic strain that is predomina...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng1447

    authors： Cazalet C,Rusniok C,Brüggemann H,Zidane N,Magnier A,Ma L,Tichit M,Jarraud S,Bouchier C,Vandenesch F,Kunst F,Etienne J,Glaser P,Buchrieser C

    更新日期：2004-11-01 00:00:00

  • Genome-wide meta-analyses identify three loci associated with primary biliary cirrhosis.

    abstract：:A genome-wide association screen for primary biliary cirrhosis risk alleles was performed in an Italian cohort. The results from the Italian cohort replicated IL12A and IL12RB associations, and a combined meta-analysis using a Canadian dataset identified newly associated loci at SPIB (P = 7.9 x 10(-11), odds ratio (OR...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng.627

    authors： Liu X,Invernizzi P,Lu Y,Kosoy R,Lu Y,Bianchi I,Podda M,Xu C,Xie G,Macciardi F,Selmi C,Lupoli S,Shigeta R,Ransom M,Lleo A,Lee AT,Mason AL,Myers RP,Peltekian KM,Ghent CN,Bernuzzi F,Zuin M,Rosina F,Borghesio E

    更新日期：2010-08-01 00:00:00

  • Transposon mutagenesis identifies genetic drivers of Braf(V600E) melanoma.

    abstract：:Although nearly half of human melanomas harbor oncogenic BRAF(V600E) mutations, the genetic events that cooperate with these mutations to drive melanogenesis are still largely unknown. Here we show that Sleeping Beauty (SB) transposon-mediated mutagenesis drives melanoma progression in Braf(V600E) mutant mice and iden...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng.3275

    authors： Mann MB,Black MA,Jones DJ,Ward JM,Yew CC,Newberg JY,Dupuy AJ,Rust AG,Bosenberg MW,McMahon M,Print CG,Copeland NG,Jenkins NA

    更新日期：2015-05-01 00:00:00

  • Germline duplication of ATG2B and GSKIP predisposes to familial myeloid malignancies.

    abstract：:No major predisposition gene for familial myeloproliferative neoplasms (MPN) has been identified. Here we demonstrate that the autosomal dominant transmission of a 700-kb duplication in four genetically related families predisposes to myeloid malignancies, including MPN, frequently progressing to leukemia. Using induc...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng.3380

    authors： Saliba J,Saint-Martin C,Di Stefano A,Lenglet G,Marty C,Keren B,Pasquier F,Valle VD,Secardin L,Leroy G,Mahfoudhi E,Grosjean S,Droin N,Diop M,Dessen P,Charrier S,Palazzo A,Merlevede J,Meniane JC,Delaunay-Darivon C,F

    更新日期：2015-10-01 00:00:00

  • Establishment of functional imprinting of the H19 gene in human developing placentae.

    abstract：:We have found that the imprinted H19 gene can be expressed either biallelically or monoallelically in the developing human placentae. H19 biallelic expression is confined to the placenta until 10 weeks of gestation, after which it becomes exclusively maternal, and does not affect allele-specificity or levels of IGF2 e...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng0795-318

    authors： Jinno Y,Ikeda Y,Yun K,Maw M,Masuzaki H,Fukuda H,Inuzuka K,Fujishita A,Ohtani Y,Okimoto T

    更新日期：1995-07-01 00:00:00

  • Error-prone bypass of DNA lesions during lagging-strand replication is a common source of germline and cancer mutations.

    abstract：:Studies in experimental systems have identified a multitude of mutational mechanisms including DNA replication infidelity and DNA damage followed by inefficient repair or replicative bypass. However, the relative contributions of these mechanisms to human germline mutation remain unknown. Here, we show that error-pron...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/s41588-018-0285-7

    authors： Seplyarskiy VB,Akkuratov EE,Akkuratova N,Andrianova MA,Nikolaev SI,Bazykin GA,Adameyko I,Sunyaev SR

    更新日期：2019-01-01 00:00:00

  • Identification of recurrent SMO and BRAF mutations in ameloblastomas.

    abstract：:Here we report the discovery of oncogenic mutations in the Hedgehog and mitogen-activated protein kinase (MAPK) pathways in over 80% of ameloblastomas, locally destructive odontogenic tumors of the jaw, by genomic analysis of archival material. Mutations in SMO (encoding Smoothened, SMO) are common in ameloblastomas o...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng.2986

    authors： Sweeney RT,McClary AC,Myers BR,Biscocho J,Neahring L,Kwei KA,Qu K,Gong X,Ng T,Jones CD,Varma S,Odegaard JI,Sugiyama T,Koyota S,Rubin BP,Troxell ML,Pelham RJ,Zehnder JL,Beachy PA,Pollack JR,West RB

    更新日期：2014-07-01 00:00:00

  • Cultivated tomato clock runs slow.

    abstract：:The plant circadian clock is a complex network of genes crucial for plant survival. A new study finds that domestication gradually slowed down the circadian clock of tomato via selection on two major genes-one that delayed phasing of the clock with daylight, whereas the other induced a longer period. ...

    journal_title：Nature genetics

    pub_type： 评论,杂志文章

    doi：10.1038/ng.3476

    authors： Kay SA,Remigereau MS

    更新日期：2016-01-01 00:00:00

  • HLA DR-DQ associations with cervical carcinoma show papillomavirus-type specificity.

    abstract：:Cervical carcinoma is now known to be associated with human papillomaviruses (HPV), but the evidence for a link with specific HLA loci is controversial. The role of genetic variation at the HLA class II loci and among HPV types in cervical carcinoma was investigated by PCR DNA amplification and oligonucleotide probe t...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng0294-157

    authors： Apple RJ,Erlich HA,Klitz W,Manos MM,Becker TM,Wheeler CM

    更新日期：1994-02-01 00:00:00

  • Expression pattern of the Kallmann syndrome gene in the olfactory system suggests a role in neuronal targeting.

    abstract：:Kallmann syndrome is a genetic disorder characterized by a defect in olfactory system development, which appears to be due to an abnormality in the migration of olfactory axons and gonadotropin releasing hormone (Gn-RH) producing neurons. The X-linked Kallmann syndrome gene shares significant similarities with molecul...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng0593-19

    authors： Rugarli EI,Lutz B,Kuratani SC,Wawersik S,Borsani G,Ballabio A,Eichele G

    更新日期：1993-05-01 00:00:00