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The apolipoprotein(a) gene is regulated by sex hormones and acute-phase inducers in YAC transgenic mice.

Abstract：

:High plasma concentrations of apolipoprotein (a) (apo(a)) have been implicated as a major independent risk factor for atherosclerosis in humans. Apo(a) is a large, evolutionarily new gene (present primarily in primates) for which considerable controversy exists concerning the factors that regulate its expression. To investigate the in vivo regulation of apo(a), we have created several lines of YAC transgenic mice containing a 110-kb human apo(a) gene surrounded by greater than 60 kb of 5' and 3' flanking DNA. Studies in humans have suggested that acute-phase inducers increase and sex steroids decrease apo(a) concentrations, but these results are controversial. Analysis of the YAC transgenic mice conclusively supports the hypothesized role of sex steroids and refutes the suggested role of acute-phase inducers in regulating the apo(a) gene.

journal_name

Nat Genet

journal_title

Nature genetics

authors

Frazer KA,Narla G,Zhang JL,Rubin EM

doi

10.1038/ng0495-424

subject

Has Abstract

pub_date

1995-04-01 00:00:00

pages

424-31

issue

4

eissn

1061-4036

issn

1546-1718

journal_volume

9

pub_type

杂志文章

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