A dynamic ratio of the alpha+ and alpha- isoforms of the tight junction protein ZO-1 is characteristic of Caco-2 cells and correlates with their degree of differentiation.

abstract：:Ghrelin-O-acyltransferase (GOAT) is a membrane-bound enzyme that attaches eight-carbon octanoate to a serine residue in ghrelin and thereby acylates inactive ghrelin to produce active ghrelin. In this study, we investigated the function of GOAT in the intestinal mucosal barrier. The intestinal mucosal barrier prevents...

journal_title：Cell biology international

authors： Tian P,Lu X,Jin N,Shi J

更新日期：2020-08-01 00:00:00

abstract：:Receptor-interacting serine/threonine kinase 4 (RIPK4) and transforming growth factor-β 1 (TGF-β1) play critical roles in the development and maintenance of the epidermis. A negative correlation between the expression patterns of RIPK4 and TGF-β signaling during epidermal homeostasis-related events and suppression of ...

journal_title：Cell biology international

authors： Dinçer T,Boz Er AB,Er İ,Toraman B,Yildiz G,Kalay E

更新日期：2020-03-01 00:00:00

abstract：:Epicatechin, a flavonoid belonging to the group of compounds collectively called catechins, have been reported to possess insulin-like properties. Besides their anti-diabetic properties, catechins also show growth inhibition. Since cytosolic pH (pHi) plays a role in cell proliferation and the Na/H exchanger (NHE) is t...

journal_title：Cell biology international

authors： Matteucci E,Rizvi SI,Giampietro O

更新日期：2001-01-01 00:00:00

abstract：:Neuroblastoma is the most common tumor diagnosed in children and infants, with high recurrence and poor prognosis. Angelica sinensis polysaccharide (AP) whose average molecular weight is 72,900 Da possesses various bioactivities. We aimed to explore the effects of AP on neuroblastoma SH-SY5Y cells as well as the under...

journal_title：Cell biology international

authors： Yang J,Shao X,Jiang J,Sun Y,Wang L,Sun L

更新日期：2018-07-01 00:00:00

abstract：:Long noncoding RNAs (lncRNAs) play important roles in diverse cellular processes and carcinogenesis. Homeobox A cluster antisense RNA 2 (HOXA-AS2) is a 1,048-basepairs lncRNA located between human HOXA3 and HOXA4 genes, whose overactivation was previously found to promote the proliferation and invasion of solid tumors...

journal_title：Cell biology international

authors： Qu Y,Wang Y,Wang P,Lin N,Yan X,Li Y

更新日期：2020-08-01 00:00:00

abstract：:The effects of melanin preparations from black yeast fungi (BYF) on the proliferation and differentiation of normal cultivated human skin keratinocytes and embryonic pulmonary fibroblasts have been investigated. Melanin preparations in the range of 5-0.1 microg/ml were optimally active, with a more pronounced effect o...

journal_title：Cell biology international

authors： Blinova MI,Yudintseva NM,Kalmykova NV,Kuzminykh EV,Yurlova NA,Ovchinnikova OA,Potokin IL

更新日期：2003-01-01 00:00:00

abstract：:TNF-α has long been implicated in the progression of rheumatoid arthritis (RA). However, how the receptors of TNF-α, namely TNFR1 and TNFR2, mediate TNF-α-induced inflammatory responses in fibroblast-like synoviocytes (FLS) in RA has not been elucidated. In the present study, primary FLS cells were isolated from RA pa...

journal_title：Cell biology international

authors： Zhang H,Xiao W

更新日期：2017-04-01 00:00:00

abstract：:ES (embryonic stem)-derived cells have been investigated in many animal models of severe injury and degenerative disease. However, few studies have examined the ability of ES-derived cells to improve functional outcome following partially damaged breast and also the modification of mammary tissue to produce costly pro...

journal_title：Cell biology international

authors： Huang HJ,Gao QS,Qian YG,Zhang YD,Tao BF,Xiang M,Peng J,Jiang SW,Hause B

更新日期：2010-10-01 00:00:00

abstract：:TZDs (thiazolidinediones) are prescribed as anti-Type II diabetes drugs, but little is known regarding whether TZDs regulate the expression of sPLA2 (secretory phospholipase A2) in macrophages. We have investigated the effects of pioglitazone on LPS (lipopolysaccharide)-induced production of TNF-alpha (tumour necrosis...

journal_title：Cell biology international

authors： Ao C,Huo Y,Qi L,Xiong Z,Xue L,Qi Y

更新日期：2010-07-01 00:00:00

abstract：:Tripartite motif-containing 22 (TRIM22) is reported to participate in numerous cellular activities. Recent studies confirm that TRIM22 is a target gene for P53, and inhibits clonogenic growth of leukemic U-937 cells. The current study aims to discover the effect of TRIM22 in progression of human chronic myeloid leukem...

journal_title：Cell biology international

authors： Li L,Qi Y,Ma X,Xiong G,Wang L,Bao C

更新日期：2018-09-01 00:00:00

abstract：:At the early stage of atherosclerosis, neointima is formed due to the migration of vascular smooth muscle cells (VSMCs) from the media to the intima. VSMCs are surrounded by highly adhesive 3D matrices. They take specific strategies to cross various 3D matrices in the media, including heterogeneous collagen and mechan...

journal_title：Cell biology international

authors： Chi Q,Shan J,Ding X,Yin T,Wang Y,Jia D,Wang G

更新日期：2017-06-01 00:00:00

abstract：:GDNF plays an important role in the survival and differentiation of primary dopaminergic neurons, but it requires multiple factors for its entire range of activities. This study investigated the effects of GDNF and its cofactors on the development of bFGF-responsive neural progenitor cells (NPCs), mesencephalic and co...

journal_title：Cell biology international

authors： Sun ZH,Lai YL,Li P,Zuo HC,Xie ZP

更新日期：2004-01-01 00:00:00

abstract：:Oxidative stress can be defined as the increase of oxidizing agents like reactive oxygen and nitrogen species, or the imbalance between the antioxidative defense mechanism and oxidants. Cell cycle checkpoint response can be defined as the arrest of the cell cycle functioning after damaging chemical exposure. This temp...

journal_title：Cell biology international

authors： Akcakaya H,Dal F,Tok S,Cinar SA,Nurten R

更新日期：2015-02-01 00:00:00

abstract：:Steroid hormones and their receptors play pivotal roles in avian reproduction and development. 17β-estradiol (E2 ) is an essential mediator in ovarian development. In this study, Day 3 (D3) chicks were injected with E2 (0.025, 0.25 or 2.5 mg/kg body weight) for 4 days to assess the effects of estrogen on avian follicl...

journal_title：Cell biology international

authors： Zhao D,Lv C,Liu G,Mi Y,Zhang C

更新日期：2017-06-01 00:00:00

abstract：:Insulin-like growth factor-1 (IGF-1) is a positive regulator in proliferation and differentiation of skeletal muscle cells, while myostatin (MSTN) is a member of transforming growth factor beta superfamily that acts as a negative regulator of skeletal muscle mass. The present study was performed to detail whether a co...

journal_title：Cell biology international

authors： Miyake M,Hayashi S,Sato T,Taketa Y,Watanabe K,Hayashi S,Tanaka S,Ohwada S,Aso H,Yamaguchi T

更新日期：2007-10-01 00:00:00

abstract：:It has been demonstrated that the crude extract of mosquito larvae alters the mitotic rate of several mouse cell populations of young growing mice (25 +/- 1 days old). Furthermore, the dialysed fraction of the extract inhibited proliferation of hepatocytes from hepatectomized adult male mice (90 days old). Sampling du...

journal_title：Cell biology international

authors： Ronderos JR,Riccillo FL,Ottino A

更新日期：1996-08-01 00:00:00

abstract：:Non-small-cell carcinoma (NSCLC) is the most common cancer along with high mortality rate worldwide. In the present study, our data showed that lncRNA MAF BZIP Transcription Factor G Antisense RNA 1 (MAFG-AS1) was over-expressed in NSCLC tissues and cell lines. Overexpression of MAFG-AS1 promoted the migration, invasi...

journal_title：Cell biology international

authors： Jia YC,Wang JY,Liu YY,Li B,Guo H,Zang AM

更新日期：2019-04-01 00:00:00

abstract：:Transforming growth factor-β (TGF-β) is a potent inhibitor of the growth of normal mammary epithelial cells, and has a pleiotropic, context-dependent, concentration-dependent action. We found attenuation of TGF-β signalling in mammary adenoma carcinoma cells. Phosphorylation at the linker site of Smad2 occurred in a c...

journal_title：Cell biology international

authors： Sengupta S,Kundu S,Bhattacharyya A

更新日期：2013-05-01 00:00:00

abstract：:Cell proliferation rates of diagnostic marrow aspirate cells of 21 children with Acute Lymphoblastic Leukaemia and 16 controls were compared using immunocytochemical labelling of PCNA and Ki-67 antigen as assessed by Confocal Laser Scanning Microscopy. The results showed an unexpected, highly significant degree of dis...

journal_title：Cell biology international

authors： Ball LM,Pope J,Howard CV,Eccles P,van Velzen D

更新日期：1994-09-01 00:00:00

abstract：:Osteosarcoma (OS) is the most common type of primary bone tumor that exhibits invasive growth and long-distance organ metastasis. Thus, investigating the specifically targeted therapeutic agents against metastatic osteosarcoma depends on understanding the molecular mechanisms. The long noncoding RNAs (lncRNA) XIST (X-...

journal_title：Cell biology international

authors： Wen JF,Jiang YQ,Li C,Dai XK,Wu T,Yin WZ

更新日期：2020-10-01 00:00:00

abstract：:Transcriptional regulation and binding interactions between soluble nucleoproteins and the hormone response elements (REs) of the rat haptoglobin (Hp) and alpha 2-macroglobulin (alpha 2MG) genes was examined in the livers of rats during the acute-phase reaction. Our results demonstrate that the elevation of the Hp and...

journal_title：Cell biology international

authors： Petrović M,Bogojević D,Grigorov I,Sevaljević L

更新日期：1995-12-01 00:00:00

abstract：:The possible role of protein kinase C (PKC) and mitogen activated protein (MAP) kinases in the stimulation of cholesterol esterification by acetylated low density lipoprotein (acLDL) in human monocyte-derived macrophages (HMDM) was studied. Cholesterol esterification, as assessed by the rate of incorporation of [3H]-o...

journal_title：Cell biology international

authors： Napolitano M,Avella M,Goode NT,Botham KM,Bravo E

更新日期：2004-01-01 00:00:00

abstract：:The single-minded 2 gene (Sim2) plays a crucial role in the mental retardation of Down Syndrome (DS). To explore how Sim2 influences spatial memory, a DNA plasmid-encoding mouse Sim2 (mSim2) wrapped with liposome was bilaterally injected into the hippocampus of rats. The effect of overexpressing mSim2 on spatial learn...

journal_title：Cell biology international

authors： Meng X,Peng B,Shi J,Zheng Y,Chen H,Zhang J,Li L,Zhang C

更新日期：2006-10-01 00:00:00

abstract：:Lysosomal permeability to potassium ions is an important property of the organelle. Influence of the membrane physical state on the potassium ion permeability of isolated lysosomes was assessed by measuring the membrane potential with bis(3-propyl-5-oxoisoxazol-4-yl)pentamethine oxonol and monitoring the lysosomal pro...

journal_title：Cell biology international

authors： Wang J,Zhang GJ

更新日期：2005-06-01 00:00:00

abstract：:X-box-binding protein 1 (XBP-1) is a basic-region leucine zipper protein in the cyclic AMP response element binding protein/activating transcription factor (CREB/ATF) family of transcription factors involved in different cell-differentiation processes. We have investigated the expression of XBP-1 in differentiating MC...

journal_title：Cell biology international

authors： Zambelli A,Mongiardini E,Villegas SN,Carri NG,Boot-Handford RP,Wallis GA

更新日期：2005-08-01 00:00:00

abstract：:To identify the molecular basis by which nonpermissive temperature (NPT) induces cell differentiation in Sertoli TTE3 cells harboring temperature-sensitive SV40 large T-antigen, we performed global scale microarray and computational gene network analyses. In TTE3 cells, inactivation of the large T-antigen by a NPT at ...

journal_title：Cell biology international

authors： Tabuchi Y,Takasaki I,Suto A,Kondo T,Suzuki Y,Obinata M

更新日期：2007-10-01 00:00:00

abstract：:Tissue engineering of bone has been increasingly used in the bone defect repair. To generate osteoblasts is a major approach, and here we have examined ways of improving the efficiency of producing osteoblasts. Adipose stem cells (ADSC) were prepared from rat mesentery tissue, and transfected with Cbfa1 gene vector or...

journal_title：Cell biology international

authors： Wang L,Wang H,Xu X,Wang D,Liu H

更新日期：2013-11-01 00:00:00

abstract：:The diabetic milieu is believed to change the activity, or result in damage of podocytes-a key component of the glomerular filtration barrier and known to secrete matrix for glomerular basement membrane. This in turn contributes to diabetic nephropathy. However, how podocyte dysfunction is triggered in diabetic nephro...

journal_title：Cell biology international

authors： Liu Y,Long L,Yuan F,Liu F,Liu H,Peng Y,Sun L,Chen G

更新日期：2015-02-01 00:00:00

abstract：:The expression and immunohistochemical localization of galectin-3, a beta-galactoside-binding protein, was studied in several mouse tissues. Galectin-3 expression was low in the cerebrum, heart, and pancreas, and moderate in the liver, ileum, kidney, and adrenal gland. High expression of galectin-3 was found in the lu...

journal_title：Cell biology international

authors： Kim H,Lee J,Hyun JW,Park JW,Joo HG,Shin T

更新日期：2007-07-01 00:00:00

abstract：:Ricin is internalized after binding at the cell surface via lectin activity of the B-chain recognizing terminal galactose residues. Ricin-A chain is then translocated to the cytosol from various endocytic structures. Cell death is the result of catalytic inactivation of protein synthesis. Using (125)I-ricin overlays, ...

journal_title：Cell biology international

authors： Alami M,Taupiac MP,Beaumelle B

更新日期：1997-03-01 00:00:00