Abstract:
:Cellular homeostasis is linked tightly to mitochondrial functions. Some damage to mitochondrial proteins and nucleic acids can lead to the depolarization of the inner mitochondrial membrane, thereby sensitizing impaired mitochondria for selective elimination by autophagy. Mitochondrial dysfunction is one of the key aspects of the pathobiology of neurodegenerative disease. Parkin, an E3 ligase located in the cytosol and originally discovered as mutated in monogenic forms of Parkinson's disease (PD), was found recently to translocate specifically to uncoupled mitochondria and to induce their autophagy.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Tanaka Adoi
10.1016/j.febslet.2010.02.060subject
Has Abstractpub_date
2010-04-02 00:00:00pages
1386-92issue
7eissn
0014-5793issn
1873-3468pii
S0014-5793(10)00164-Xjournal_volume
584pub_type
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