The biocompatability of mesoporous inorganic-organic hybrid resin films with ionic and hydrophilic characteristics.

abstract：:Cancer therapeutics are developed through extensive screening; however, many therapeutics evaluated with 2D in vitro cultures during pre-clinical trials suffer from lower efficacy in patients. Replicating the in vivo tumor microenvironment in vitro with three-dimensional (3D) porous scaffolds offers the possibility of...

journal_title：Biomaterials

authors： Florczyk SJ,Wang K,Jana S,Wood DL,Sytsma SK,Sham J,Kievit FM,Zhang M

更新日期：2013-12-01 00:00:00

abstract：:Intravascular catheter-associated infections (CAIs), which are normally induced by microbial adhesion and subsequent biofilm formation, are a major cause of morbidity and mortality. Therefore, strategies to prevent CAIs are in great demand. In this study, a series of diblock copolymers of PEG and cationic polycarbonat...

journal_title：Biomaterials

authors： Ding X,Yang C,Lim TP,Hsu LY,Engler AC,Hedrick JL,Yang YY

更新日期：2012-10-01 00:00:00

abstract：:We studied the adhesion and proliferation of human endothelial cells on photochemically modified polytetrafluoroethylene samples. The polymer surfaces were modified by exposure to the ultraviolet light of a Xe(2)(*)-excimer lamp at a wavelength of 172 nm in an ammonia atmosphere. Treatment times were between 10 and 20...

journal_title：Biomaterials

authors： Gumpenberger T,Heitz J,Bäuerle D,Kahr H,Graz I,Romanin C,Svorcik V,Leisch F

更新日期：2003-12-01 00:00:00

abstract：:We describe a near-infrared fluorescent heptamethine dye (IR-780 iodide) with unique properties for sentinel lymph node (SLN) mapping in both small and large animals. This dye has a significant photobrightening effect in serum and a long retention time in the lymphatic system which allows to acquire much higher signal...

journal_title：Biomaterials

authors： Zhang C,Wang S,Xiao J,Tan X,Zhu Y,Su Y,Cheng T,Shi C

更新日期：2010-03-01 00:00:00

abstract：:Chitosans with various degrees of deacetylation were synthesized by acetylation with acetic anhydride. These chitosans were evaluated for efficacy of nanoparticle formation, DNA binding efficiency, morphology, and in vitro and in vivo gene transfection efficiency. DNA binding efficacy was reduced as degree of deacetyl...

journal_title：Biomaterials

authors： Kiang T,Wen J,Lim HW,Leong KW

更新日期：2004-10-01 00:00:00

abstract：:The poor biocompatibility of metallic coronary stents which leads to un-satisfying restenosis rates is mainly caused by contact activation of blood cells, smooth muscle cells and endothelial cells. Mimicking a metal surface with a biocompatible coating that actively suppresses mechanisms leading to restenosis may over...

journal_title：Biomaterials

authors： Lahann J,Klee D,Pluester W,Hoecker H

更新日期：2001-04-01 00:00:00

abstract：:Biomimetic strategies focusing on presenting short bioadhesive oligopeptides, including the arginine-glycine-aspartic acid (RGD) motif present in numerous adhesive proteins, on a non-fouling support have emerged as promising approaches to improve cellular activities and healing responses. Nevertheless, these bio-inspi...

journal_title：Biomaterials

authors： Petrie TA,Capadona JR,Reyes CD,García AJ

更新日期：2006-11-01 00:00:00

abstract：:We design a class of imprinted hybrid microgels that can optically monitor glucose levels with high sensitivity and selectivity in complex media at physiological pH, acting like a "glucose-indicator". Such imprinted hybrid microgels were made of Ag nanoparticles (NPs) in situ immobilized in molecularly imprinted gluco...

journal_title：Biomaterials

authors： Wu W,Shen J,Li Y,Zhu H,Banerjee P,Zhou S

更新日期：2012-10-01 00:00:00

abstract：:The phenomenon of light-induced cell detachment is reported. Mouse calvaria-derived, pre-osteoblastic (MC3T3-E1) cells were cultured on a TiO(2) nanodot-coated quartz substrate. After 20 min of UV365 illumination, over 90% of the cells would detach from the surface. Moreover, intact cell sheets could be obtained in th...

journal_title：Biomaterials

authors： Hong Y,Yu M,Weng W,Cheng K,Wang H,Lin J

更新日期：2013-01-01 00:00:00

abstract：:The nanopore size and roughness of nanoporous surface are two critical variables in determining stem cell fate, but little is known about the contribution from each cue individually. To address this gap, we use two-dimensional nanoporous membranes with controlled nanopore size and roughness to culture bone marrow-deri...

journal_title：Biomaterials

authors： Xia J,Yuan Y,Wu H,Huang Y,Weitz DA

更新日期：2020-07-01 00:00:00

abstract：:3D printing is known as a cost-effective technique that shows huge potential in fabrication of graft substitutes for bone tissue regeneration. However, the tradeoff between 3D printability, mechanical strength and bioactivity of the printed materials (i.e., inks) remains a challenge. In this work, we present a novel p...

journal_title：Biomaterials

authors： Yang Y,Zhang Q,Xu T,Zhang H,Zhang M,Lu L,Hao Y,Fuh JH,Zhao X

更新日期：2020-12-01 00:00:00

abstract：:Intercellular interactions in the cell microenvironment play a critical role in determining cell fate, but the effects of these interactions on pathways governing human embryonic stem cell (hESC) behavior have not been fully elucidated. We and others have previously reported that 3-D culture of hESCs affects cell fate...

journal_title：Biomaterials

authors： Azarin SM,Lian X,Larson EA,Popelka HM,de Pablo JJ,Palecek SP

更新日期：2012-03-01 00:00:00

abstract：:Theranostics, the integration of diagnostics and therapies, has become a new concept in the battles with various major diseases such as cancer. Here, we report a multifunctional nanoplatform, which is developed by covalently grafting core-shell structured upconversion nanoparticles (UCNPs) with nanographene oxide (NGO...

journal_title：Biomaterials

authors： Wang Y,Wang H,Liu D,Song S,Wang X,Zhang H

更新日期：2013-10-01 00:00:00

abstract：:Apart from partial or total joint replacement, no surgical procedure is currently available to treat large and deep cartilage defects associated with advanced diseases such as osteoarthritis. In this work, we developed a perfusion bioreactor system to engineer human cartilage grafts in a size with clinical relevance f...

journal_title：Biomaterials

authors： Santoro R,Olivares AL,Brans G,Wirz D,Longinotti C,Lacroix D,Martin I,Wendt D

更新日期：2010-12-01 00:00:00

abstract：:To investigate the role that the micro/nano-environment plays on the differentiation pathway of bone marrow stromal cells (BMSCs) into osteoblasts, we employed a 2D substrate coated with turnip yellow mosaic virus (TYMV) particles. TYMV is a non-enveloped icosahedral plant virus which has an average diameter 28 nm and...

journal_title：Biomaterials

authors： Kaur G,Valarmathi MT,Potts JD,Wang Q

更新日期：2008-10-01 00:00:00

abstract：:Mandibular reconstruction requires functional and aesthetic repair and is further complicated by contamination from oral and skin flora. Antibiotic-releasing porous space maintainers have been developed for the local release of vancomycin and to promote soft tissue attachment. In this study, mandibular defects in six ...

journal_title：Biomaterials

authors： Watson E,Smith BT,Smoak MM,Tatara AM,Shah SR,Pearce HA,Hogan KJ,Shum J,Melville JC,Hanna IA,Demian N,Wenke JC,Bennett GN,van den Beucken JJJP,Jansen JA,Wong ME,Mikos AG

更新日期：2020-10-01 00:00:00

abstract：:Microbial polyhydroxyalkanoates (PHA) including poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) (PHBHHx) were found to induce chondrogenesis of mesenchymal stem cells (MSCs) and preserve chondrocytic phenotype as well as support chondrocytes-specific extracellular matrix (ECM) secretion. In this study, mouse MSCs cultur...

journal_title：Biomaterials

authors： Yan C,Wang Y,Shen XY,Yang G,Jian J,Wang HS,Chen GQ,Wu Q

更新日期：2011-09-01 00:00:00

abstract：:A method to fabricate porous, biodegradable conduits using a combined injection molding, thermally induced phase transition technique was developed which produced conduits with dimensionally toleranced, longitudinally aligned channels. The geometry of the channels was designed to approximate the architecture of periph...

journal_title：Biomaterials

authors： Sundback C,Hadlock T,Cheney M,Vacanti J

更新日期：2003-02-01 00:00:00

abstract：:Osteoarthritis (OA) is a progressively degenerative disease that is accompanied by articular cartilage deterioration, sclerosis of the underlying bone and ultimately joint destruction. Although therapeutic medicine and surgical treatment are done to alleviate the symptoms of OA, it is difficult to restore normal carti...

journal_title：Biomaterials

authors： Kim SJ,Kim JE,Kim SH,Kim SJ,Jeon SJ,Kim SH,Jung Y

更新日期：2016-01-01 00:00:00

abstract：:Semiconduction activation energies of adenine, guanine, thymine and uracil complexes with acridine orange dye at various dye concentrations were measured in both Ohmic and space charge limited (SCL) current regimes. The behaviour of the complexes is non-extrinsic at high dye concentrations but extrinsic at low dye con...

journal_title：Biomaterials

authors： Sarkar D,Misra TN

更新日期：1989-04-01 00:00:00

abstract：:Safety and high efficacy of vectors are essential requirements for gene therapy. To address these challenges, poly(carboxy betaine methacrylate ethyl ester)-poly(carboxy betaine methacrylate) (PCBMAEE-PCBMA) diblock copolymers were synthesized to form core-shell vector for gene delivery. The hydrophobic PCBMAEE segmen...

journal_title：Biomaterials

authors： Zhang J,Wang Z,Lin W,Chen S

更新日期：2014-09-01 00:00:00

abstract：:Periprosthetic tissues observed at sites of loose total joint implants exhibit abundant macrophages, lymphocytes, fibroblasts and particulate debris. Macrophages phagocytose orthopaedic debris and release proinflammatory cytokines, chemokines, matrix metalloproteinases and other substances. In addition, other cell typ...

journal_title：Biomaterials

authors： Trindade MC,Lind M,Sun D,Schurman DJ,Goodman SB,Smith RL

更新日期：2001-02-01 00:00:00

abstract：:The changes in protein adsorption onto aluminium surfaces coated with different thicknesses of oxide layers were examined. The oxide layers on aluminium substrates were derived by the anodizing technique. Protein adsorption studies were conducted using 125I-labelled albumin and the amount of albumin adsorbed was estim...

journal_title：Biomaterials

authors： Sharma CP,Sunny MC

更新日期：1990-05-01 00:00:00

abstract：:Resorbable calcium phosphate (CaP) biomaterials have demonstrated considerable efficacy in bone reconstructive surgery. Furthermore, bisphosphonates (BPs) are well known anti-resorptive agents largely used in clinical treatments for osteoporosis. An injectable BP-combined CaP matrix has been developed in order to biol...

journal_title：Biomaterials

authors： Verron E,Gauthier O,Janvier P,Pilet P,Lesoeur J,Bujoli B,Guicheux J,Bouler JM

更新日期：2010-10-01 00:00:00

abstract：:Single-stranded oligonucleotide-conjugated lipids (ssDNA-PEG-lipids) that associate with the cell membrane confer to the cell an artificial adhesive capability via sequence-specific hybridization to complementary oligonucleotides, forming bonds of double stranded oligonucleotides (dsDNA). Such artificial tethers permi...

journal_title：Biomaterials

authors： Hoffecker IT,Takemoto N,Arima Y,Iwata H

更新日期：2015-01-01 00:00:00

abstract：:The aim of this study was to develop a hydrogel which would be suitable for corneal cell re-epithelialization when used as a corneal implant. To achieve this, a series of hydrogels were functionalized with primary amines by post-polymerization reactions between amine compounds and glycidyl ether groups attached to the...

journal_title：Biomaterials

authors： Rimmer S,Johnson C,Zhao B,Collier J,Gilmore L,Sabnis S,Wyman P,Sammon C,Fullwood NJ,MacNeil S

更新日期：2007-12-01 00:00:00

abstract：:A series of novel cationic star polymers were synthesized by conjugating multiple oligoethylenimine (OEI) arms onto an alpha-cyclodextrin (alpha-CD) core as nonviral gene delivery vectors. The molecular structures of the alpha-CD-OEI star polymers, which contained linear or branched OEI arms with different chain lengt...

journal_title：Biomaterials

authors： Yang C,Li H,Goh SH,Li J

更新日期：2007-07-01 00:00:00

abstract：:Literature has shown that slowing down the curing rate of light-initiated resin composites by lowering the light intensity of the light source improved the integrity of the adhesive composite-cavity interface as a result of a more gradual contraction stress development. This study investigated how the curing rate coul...

journal_title：Biomaterials

authors： Venhoven BA,de Gee AJ,Davidson CL

更新日期：1996-12-01 00:00:00

abstract：:Previous studies have shown that high impact strength can be conferred on denture-base poly(methyl methacrylate) polymers by modification with acrylic-terminated butadiene-styrene block copolymers, and that the acrylic end-group was necessary for effective reinforcement. It is now shown that, by solvent extraction stu...

journal_title：Biomaterials

authors： Rodford RA,Braden M

更新日期：1992-01-01 00:00:00

abstract：:The purpose of the present work was to examine the effect of different Ti-6Al-4V surface treatments on osteoblasts behaviour. Previous work in this laboratory has demonstrated that an ageing treatment reduces metal ion release from this alloy compared to standard passivation procedures. In this study. human osteosarco...

journal_title：Biomaterials

authors： Ku CH,Pioletti DP,Browne M,Gregson PJ

更新日期：2002-03-01 00:00:00