Taurine attenuates radiation-induced lung fibrosis in C57/Bl6 fibrosis prone mice.

Abstract:

INTRODUCTION:The amino acid taurine has an established role in attenuating lung fibrosis secondary to bleomycin-induced injury. This study evaluates taurine's effect on TGF-beta1 expression and the development of lung fibrosis after single-dose thoracic radiotherapy. METHODS:Four groups of C57/Bl6 mice received 14 Gy thoracic radiation. Mice were treated with taurine or saline supplementation by gavage. After 10 days and 14 weeks of treatment, TGF-beta1 levels were measured in serum and bronchoalveolar lavage fluid (BALF). Lung collagen content was determined using hydroxyproline analysis. RESULTS:Ten days post radiotherapy, serum TGF-beta1 levels were significantly lower after gavage with taurine rather than saline (P = 0.033). BALF TGF-beta1 at 10 days was also significantly lower in mice treated with taurine (P = 0.031). Hydroxyproline content was also significantly lower at 14 weeks in mice treated with taurine (P = 0.020). CONCLUSION:This study presents novel findings of taurine's role in protecting from TGF-beta1-associated development of lung fibrosis after thoracic radiation.

journal_name

Ir J Med Sci

authors

Robb WB,Condron C,Moriarty M,Walsh TN,Bouchier-Hayes DJ

doi

10.1007/s11845-009-0389-2

subject

Has Abstract

pub_date

2010-03-01 00:00:00

pages

99-105

issue

1

eissn

0021-1265

issn

1863-4362

journal_volume

179

pub_type

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