Matrix metalloproteinase-2 promoter variability in psoriasis.

abstract：:Epstein-Barr virus (EBV) can infect epithelial cells as well as B lymphocytes. Infection of the male and female genital tracts has recently been demonstrated, and it has been suggested that the virus may be sexually transmissible. In our study we investigated whether EBV can be found in the anal region of sexually act...

journal_title：Archives of dermatological research

authors： Näher H,Lenhard B,Wilms J,Nickel P

更新日期：1995-01-01 00:00:00

abstract：:The deposition of immunoglobulin (Ig) at the dermo-epidermal junction (DEJ) of the skin, frequently observed in autoimmune mouse strains, is similar to that seen in patients with systemic lupus erythematosus (SLE). MRL/Mp-lpr/lpr (MRL/lpr) mice have an autosomal recessive mutant gene, lpr, which produces massive T-cel...

journal_title：Archives of dermatological research

authors： Furukawa F,Ohshio G,Imamura S

更新日期：1993-01-01 00:00:00

abstract：:The presence, distribution and cellular localization of tumour necrosis factor-alpha (TNF alpha) were investigated in normal human and murine epidermis using immunohistological and immunoelectron microscopic methods with monoclonal and polyclonal antibodies. The immunostaining revealed an intercellular plasma membrane...

journal_title：Archives of dermatological research

authors： Kolde G,Schulze-Osthoff K,Meyer H,Knop J

更新日期：1992-01-01 00:00:00

abstract：:Whereas the inflammatory infiltrates of malignant melanoma have been widely investigated, little is known about the infiltrates accompanying benign melanocytic naevi. Using monoclonal antibodies directed against HLA-DR antigens, the CD1 antigen, the transferrin receptor and functionally divergent macrophage subpopulat...

journal_title：Archives of dermatological research

authors： Bröcker EB,Reckenfeld C,Hamm H,Ruiter DJ,Sorg C

更新日期：1992-01-01 00:00:00

abstract：:There are differences concerning reported mortality rates and prognostic factors of bullous pemphigoid (BP) patients in different studies. Our objectives were to evaluate the mortality rates and prognostic factors among Israeli BP patients compared to matched control subjects. Three age- and sex-matched patients witho...

journal_title：Archives of dermatological research

authors： Rozenblat M,Halaj A,Rozenblat T,Fisher S,Sah M,Dodiuk-Gad RP,Ziv M

更新日期：2019-01-01 00:00:00

abstract：:Thymocyte selection-associated high-mobility group box (TOX) is aberrantly expressed in cutaneous T-cell lymphomas. In a recent study, TOX expression was noted unexpectedly in the follicle center (germinal center) B-cells of reactive lymph nodes and tonsils, used as external controls. To evaluate whether TOX is also e...

journal_title：Archives of dermatological research

authors： Schrader AM,Jansen PM,Willemze R

更新日期：2016-08-01 00:00:00

abstract：:In a group of 40 patients suffering from wide-spread psoriasis oral administration of a retinoid (Ro 10-9359) was followed by PUVA therapy. The clearance rate was increased by 30% as compared to PUVA alone. Except for cheilitis no side effects were seen. Histological analysis in 20 patients before, during and after th...

journal_title：Archives of dermatological research

authors： Heidbreder G,Christophers E

更新日期：1979-05-04 00:00:00

abstract：:Sphingosylphosphorylcholine (SPC) has been reported to stimulate wound healing by its potent mitogenic effect. Fibronectin (FN) is a cell-adhesion protein that plays an important role in cell migration and collagen deposition during wound healing. In order to elucidate further the mechanism involved in the accelerated...

journal_title：Archives of dermatological research

authors： Suhr KB,Tsuboi R,Seo EY,Piao YJ,Lee JH,Park JK,Ogawa H

更新日期：2003-01-01 00:00:00

abstract：:Antihistamines are the first-line treatment for chronic urticaria (CU). However, some CU patients are relatively refractory to antihistamines. The mechanism underlying the interindividual variation is still unknown. The α-chain of the high-affinity IgE receptor is crucial to the IgE-mediated allergic response. The pre...

journal_title：Archives of dermatological research

authors： Guo A,Zhu W,Zhang C,Wen S,Chen X,Chen M,Zhang J,Su J,Chen W,Zhao Y,Yan S,He Y,Liu Z,Zhou H,Chen X,Li J

更新日期：2015-03-01 00:00:00

abstract：:The injured skin produces a number of mediators that directly or indirectly modulate cell chemotaxis, migration, proliferation, and angiogenesis. Components of the kinin pathway including the kinin B1 receptor (B1R) have been found to occur in the human skin, but information about its role on keratinocyte biology is s...

journal_title：Archives of dermatological research

authors： Mejia AJ,Matus CE,Pavicic F,Concha M,Ehrenfeld P,Figueroa CD

更新日期：2015-11-01 00:00:00

abstract：:Koebner response was studied in 35 psoriatic patients. Two punch biopsies per patient were taken from non-lesional psoriatic skin before, and 6 h, 2 days, 7 days, 14 days and 21 days after, tape stripping. Alterations in the numbers of CD1+ Langerhans cells, CD4+ and CD8+ T cells and CD11c+ macrophages were mapped mor...

journal_title：Archives of dermatological research

authors： Paukkonen K,Naukkarinen A,Horsmanheimo M

更新日期：1992-01-01 00:00:00

abstract：:T Cells from 14 patients in the active stage of bullous pemphigoid and 10 patients in the inactive stage of the disease were studied with Leu-1, Leu-2, and Leu-3 monoclonal antibodies. The proportions of total T cells and T cells expressing either helper or suppressor phenotype in the peripheral blood of patients were...

journal_title：Archives of dermatological research

authors： Ahmed AR

更新日期：1985-01-01 00:00:00

abstract：:Interleukin-6-like (IL-6-like) immunoreactivity was sought in inflamed and normal human skin using the same immunohistochemical technique as for detection of neuropeptides. Such immunoreactivity was found in dermal and in a few intraepidermal nerve-like fibres in biopsy specimens from inflamed skin from patients with ...

journal_title：Archives of dermatological research

authors： Nordlind K,Chin LB,Ahmed AA,Brakenhoff J,Theodorsson E,Lidén S

更新日期：1996-07-01 00:00:00

abstract：:The mechanism of action of thalidomide in the treatment of patients with Behçet's disease (BD) is poorly understood. There is some evidence to suggest that certain immunological abnormalities are associated with the pathogenesis of BD. A BD-like mouse model induced by herpes simplex virus (HSV) inoculation shows simil...

journal_title：Archives of dermatological research

authors： Lee ES,Kim YA,Kwon HJ,Bang D,Lee S,Sohn S

更新日期：2004-09-01 00:00:00

abstract：:The effect of skin delipidization in humans on the percutaneous penetration of hydrocortisone was investigated in a cross-over trial. The delipidizing agent was 1:1:1 trichloroethane, a common industrial organic solvent. The findings do not show any significant difference in the topical absorption of hydrocortisone wi...

journal_title：Archives of dermatological research

authors： Bucks DA,Maibach HI,Menczel E,Wester RC

更新日期：1983-01-01 00:00:00

abstract：:The skin is the major site on anaphylaxis, and cutaneous mast cells have an important role in its reactions. The isolation and purification of rat cutaneous mast cells are described here. Rat abdominal skin was digested with collagenase and hyaluronidase, and centrifuged with Percoll. The buoyant density of cutaneous ...

journal_title：Archives of dermatological research

authors： Hachisuka H,Kusuhara M,Higuchi M,Okubo K,Sasai Y

更新日期：1988-01-01 00:00:00

abstract：:The topical application of a mixture of sugar and povidone--iodine (PI) has been reported to accelerate the healing of cutaneous wounds and ulcers by promoting re-epithelialization and granulation tissue formation as well as having an anti-microbial effect. To clarify the mechanisms accounting for the efficacy of a 70...

journal_title：Archives of dermatological research

authors： Nakao H,Yamazaki M,Tsuboi R,Ogawa H

更新日期：2006-09-01 00:00:00

abstract：:The calcipotriol/betamethasone dipropionate fixed-combination gel is widely used for topical treatment of psoriasis vulgaris. It has been hypothesized that calcipotriol counteracts glucocorticoid-induced skin atrophy which is associated with changes in the extracellular matrix (ECM). To elucidate the combined effects ...

journal_title：Archives of dermatological research

authors： Norsgaard H,Kurdykowski S,Descargues P,Gonzalez T,Marstrand T,Dünstl G,Røpke M

更新日期：2014-10-01 00:00:00

abstract：:Although chemokines are critical elements for the selective attraction and activation of various leukocyte subsets in the inflammatory process, there are few findings concerning T helper (Th) 1 or Th2 chemokines in autoimmune blistering disease (ABD). To determine whether serum levels of chemokines that are preferenti...

journal_title：Archives of dermatological research

authors： Echigo T,Hasegawa M,Shimada Y,Inaoki M,Takehara K,Sato S

更新日期：2006-06-01 00:00:00

abstract：:Recent studies have demonstrated that tumor necrosis factor-alpha (TNF-alpha) selectively decreases production of collagens I and III, the major types of collagen in the dermis, and increases production of collagenase in cultured dermal fibroblasts. The effects of TNF-alpha on collagens I, III and VI, fibronectin and ...

journal_title：Archives of dermatological research

authors： Takeda K,Hatamochi A,Arakawa M,Ueki H

更新日期：1993-01-01 00:00:00

abstract：:Enhancement strategies are necessary to improve the dermal/transdermal bioavailability of drugs applied to the skin due to its amazing barrier, the stratum corneum. Strategies to overcome this barrier, thus improving drug release to the skin include the use of penetration enhancers, specific delivery systems, supersat...

journal_title：Archives of dermatological research

authors： Pierre MB,Dos Santos Miranda Costa I

更新日期：2011-11-01 00:00:00

abstract：:Organ size regulation is a highly coordinated process involving complex mechanisms. Yes-associated protein (YAP) and transcriptional co-activator with PDZ-binding motif, also known as WWTR1 (TAZ) have recently been linked to organ size determination and cell proliferation. Pilomatrixoma (PM) is a benign tumor of the a...

journal_title：Archives of dermatological research

authors： Cappellesso R,Bellan A,Saraggi D,Salmaso R,Ventura L,Fassina A

更新日期：2015-05-01 00:00:00

abstract：:A 2% commercial solution formulation of 5-fluorouracil (5-FU) was significantly better at delivering 5-FU than either a 1% or 5% solution. Among single component suspension formulations the highest transdermal delivery was obtained from the vehicle in which 5-FU was least soluble, isopropyl myristate (IPM), while chan...

journal_title：Archives of dermatological research

authors： Sherertz EF,Sloan KB,McTiernan RG

更新日期：1990-01-01 00:00:00

abstract：:This study was designed to investigate the effects of griseofulvin, 5-fluorocytosine (5-FC), and amphotericin B on pancreatic and gastric secretion after the administration of a single large dose, or repeated small doses for 3 weeks, in male albino rats. The exocrine functions of the main digestive glands were only sl...

journal_title：Archives of dermatological research

authors： Park YK,Lee S,Kim WJ,Hong SS

更新日期：1979-10-01 00:00:00

abstract：:Typical confluent lesions of lichen planus were transplanted onto nude mice and cultured in organ culture. The characteristic histologic appearance of lichen planus disappeared after grafting and became similar to normal skin within 6 weeks on nude mice; the dense lymphocyte infiltrate in dermis disappeared, the basal...

journal_title：Archives of dermatological research

authors： Tammi R,Hyyryläinen A,Fräki JE

更新日期：1988-01-01 00:00:00

abstract：BACKGROUND:Data on how patients with a history of skin cancer apply sunscreen are lacking. OBJECTIVE:To characterize (1) gender differences in sunscreen application technique (quantity used, anatomic site coverage, and time allocated) and (2) differences in sunscreen application to unaffected skin versus previous skin...

journal_title：Archives of dermatological research

authors： Dang J,Reserva J,Tung-Hahn E,Vasicek B,Krol C,Adams W,Tung R,Alam M

更新日期：2020-12-01 00:00:00

abstract：:Human epidermal keratinocytes were grown in culture and the uptake of hematoporphyrin derivatives (HPDs) used in photodynamic therapy was estimated. Keratinocytes loaded with HPDs were irradiated with laser light of 632 nm generated by a helium-neon laser and cell toxicity was determined by the trypan blue exclusion t...

journal_title：Archives of dermatological research

authors： Artuc M,Ramshad M,Kappus H

更新日期：1989-01-01 00:00:00

abstract：:Three per cent boric acid incorporated in an anhydrous, water-emulsifying ointment causes no increase of boron levels in blood and urine during a period of 1-9 days after a single topical application. The same amount of boric acid incorporated in a water-based jelly does cause an increase in blood and urine levels, be...

journal_title：Archives of dermatological research

authors： Stüttgen G,Siebel T,Aggerbeck B

更新日期：1982-01-01 00:00:00

abstract：:Vitiliginous patients undergoing photochemotherapy with TMP were less susceptible to a sun burn. To investigate this point, the MED for UV-B was measured before, 2 h, and 24 h after oral intake of TMP in 10 healthy volunteers. There was an increase of MED when UV exposure had taken place 2 h after TMP intake (P < 0.01...

journal_title：Archives of dermatological research

authors： Agache PG,Coupez L

更新日期：1980-01-01 00:00:00

abstract：:Mitochondrial DNA (mtDNA) mutations have recently been proposed as important contributors to ageing and degenerative diseases. In this study, we applied the polymerase chain reaction technique to detect 4.977 bp-deleted mtDNA, the most common and abundant deletion of mtDNA, in normal human skin. None of the skin speci...

journal_title：Archives of dermatological research

authors： Yang JH,Lee HC,Lin KJ,Wei YH

更新日期：1994-01-01 00:00:00