当前位置： SCI文献检索 > JOURNAL OF ETHNOPHARMACOLOGY期刊下所有文献 > Inhibition of Helicobacter pylori-induced inflammation in human gastric epithelial AGS cells by Phyllanthus urinaria extracts.

Inhibition of Helicobacter pylori-induced inflammation in human gastric epithelial AGS cells by Phyllanthus urinaria extracts.

Abstract：

AIM OF THE STUDY:Helicobacter pylori is linked to a majority of peptic ulcers and to some types of gastric cancer, and its resistance to antibiotic treatment is now found worldwide. This study is aimed at evaluating the antimicrobial activity of Phyllanthus urinaria Linnea (Euphorbiaceae), chloroform (PUC) and methanol (PUM) extracts, and its eight isolates on H. pylori-infected human gastric epithelial AGS cells. MATERIALS AND METHODS:The in vitro anti-bacterial activity of P. urinaria chloroform (PUC) and methanol (PUM) extracts, and its eight isolates were determined. Additional experiments were also performed to know the PUC and PUM ability to inhibit the H. pylori adhesion to and invasion of AGS cells, in addition to the effect of PUC on NF-kappaB activity as well as IL-8 synthesis during H. pylori infection of AGS cells. RESULTS:The results revealed that crude extracts PUC and PUM showed potent antimicrobial activity against H. pylori than pure isolates. On the other hand, in vitroH. pylori-infection model revealed that the inhibition of bacterial adhesion and invasion to AGS cells has dramatically reduced by treatment of extract PUC, while PUM has the same moderate effect. Furthermore, H. pylori-induced nuclear factor (NF)-kappaB activation, and the subsequent release of interleukin (IL)-8 in AGS cells were also inhibited by the extract PUC. CONCLUSIONS:These results open the possibility of considering P. urinaria a chemopreventive agent for peptic ulcer or gastric cancer, but this bioactivity should be confirmed in vivo in the future.

journal_name

J Ethnopharmacol

journal_title

Journal of ethnopharmacology

authors

Lai CH,Fang SH,Rao YK,Geethangili M,Tang CH,Lin YJ,Hung CH,Wang WC,Tzeng YM

doi

10.1016/j.jep.2008.05.022

subject

Has Abstract

pub_date

2008-08-13 00:00:00

pages

522-6

issue

3

eissn

0378-8741

issn

1872-7573

pii

S0378-8741(08)00284-5

journal_volume

118

pub_type

杂志文章

相关文献

JOURNAL OF ETHNOPHARMACOLOGY文献大全
  • Enigma of drug-induced altered states of consciousness among the !Kung Bushmen of the Kalahari Desert.

    abstract：:This article examines data presented in Katz' book, Boiling Energy: Community Healing among the Kalahari Kung, particularly with regard to plant drugs present in the community during the 1968 visit. The author argues that the similarity of the Bushman trance state, kia and that of drug-induced altered states of consci...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/0378-8741(86)90168-6

    authors： Dobkin De Rios M

    更新日期：1986-03-01 00:00:00

  • Immunostimulant principles from Curculigo orchioides.

    abstract：:Curculigo orchioides Gaerten belongs to the family Amaryllidaceae. The rhizomes of the plants are used for the treatment of decline in strength, jaundice and asthma. Its methanolic extract has been shown to enhance phagocytic activity of macrophages. Present studies have led to the isolation of two phenolic glycosides...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/s0378-8741(03)00160-0

    authors： Lakshmi V,Pandey K,Puri A,Saxena RP,Saxena KC

    更新日期：2003-12-01 00:00:00

  • Inhibitory activity of Chrysanthemi sibirici herba extract on RBL-2H3 mast cells and compound 48/80-induced anaphylaxis.

    abstract：:The effects of extracts from various oriental medicinal herbs on mast cell-mediated allergic reaction were investigated. Among them, Chrysanthemi sibirici herba ethanol extract exerted the potent inhibitory activity on antigen-induced degranulation in RBL-2H3 mast cells. Chrysanthemi sibirici herba dose-dependently in...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2004.08.023

    authors： Lee JH,Seo JY,Ko NY,Chang SH,Her E,Park T,Lee HY,Han JW,Kim YM,Choi WS

    更新日期：2004-12-01 00:00:00

  • Anti-inflammatory and anti-nociceptive activities of Smilax china L. aqueous extract.

    abstract：:The aqueous extract of the tuber of Smilax china L., popularly known in China as "jin gang ten", was tested for its anti-inflammatory activities in rats by egg-albumin-induced edema and anti-nociceptive effects in mice using hot-plate test and acetic acid-induced abdominal constriction test, respectively. The aqueous ...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2005.08.004

    authors： Shu XS,Gao ZH,Yang XL

    更新日期：2006-02-20 00:00:00

  • The gastroprotective activity of the ethanol extract of Ageratum conyzoides.

    abstract：:The ethanol extract of Ageratum conyzoides was evaluated for gastroprotection in rats using the Ibuprofen, ethanol and cold restraint stress ulcer models. Efficacy was assessed by determination of mean ulcer size, ulcer number and ulcer index. Oral administration of the ethanol extract at dose levels of 500 and 750 mg...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/s0378-8741(03)00050-3

    authors： Shirwaikar A,Bhilegaonkar PM,Malini S,Kumar JS

    更新日期：2003-05-01 00:00:00

  • In vivo and in vitro effect of latex of Calotropis procera on gastrointestinal smooth muscles.

    abstract：:The present study was carried out to evaluate the effect of dry latex (DL) of Calotropis procera on smooth muscles of gastrointestinal tract. Oral administration of DL to rats (50-1000 mg/kg) produced a dose-dependent decrease in intestinal transit along with a decrease in intestinal content as compared to control gro...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2004.04.013

    authors： Kumar VL,Shivkar YM

    更新日期：2004-08-01 00:00:00

  • Immunostimulant effects of Capparis zeylanica Linn. leaves.

    abstract：:The present study was undertaken to explore the immunomodulatory activity of ethanolic and water extracts of Capparis zeylanica Linn. (family: Capparidaceae) leaves on neutrophil adhesion test, humoral response to sheep red blood cells, delayed-type hypersensitivity, phagocytic activity and cyclophosphamide-induced my...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2006.03.041

    authors： Ghule BV,Murugananthan G,Nakhat PD,Yeole PG

    更新日期：2006-11-24 00:00:00

  • Anti-angiogenic, antioxidant and xanthine oxidase inhibition activities of the mushroom Phellinus linteus.

    abstract：:Fruiting bodies of Phellinus linteus were extracted with 70% ethanol at room temperature. The Phellinus linteus extract (PL) showed strong anti-angiogenic activity, which was detected using the chick embryo chorioallantoic membrane (CAM) assay. The in vitro antioxidant activities of PL were evaluated using two differe...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/s0378-8741(03)00178-8

    authors： Song YS,Kim SH,Sa JH,Jin C,Lim CJ,Park EH

    更新日期：2003-09-01 00:00:00

  • The pharmacy of the Benedictine monks: the use of medicinal plants in Northeast Brazil during the nineteenth century (1823-1829).

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:The health of nineteenth century Brazilians is only alluded to in historical documents, and researchers still have much to discover. AIM OF THE STUDY:This study aims to show the medicinal plants used in the 19th century in Brazil. MATERIALS AND METHODS:To this end, information was obtai...

    journal_title：Journal of ethnopharmacology

    pub_type： 历史文章,杂志文章

    doi：10.1016/j.jep.2011.11.014

    authors： Medeiros MF,de Albuquerque UP

    更新日期：2012-01-06 00:00:00

  • Pharmacological screening of the anti-ulcerogenic effects of some Jordanian medicinal plants in rats.

    abstract：:Ethanolic extracts of 18 medicinal plants traditionally used in Jordan for the treatment of gastric ulcers were evaluated for their possible anti-ulcer activity. Among the tested plants, 12 extracts lowered the severity of ethanol-induced gastric damage in rats with curative ratios ranging from 62.9 to 99.5%. The most...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/s0378-8741(98)00126-3

    authors： Alkofahi A,Atta AH

    更新日期：1999-11-30 00:00:00

  • Pharmacological basis for use of Lychnophora trichocarpha in gouty arthritis: anti-hyperuricemic and anti-inflammatory effects of its extract, fraction and constituents.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:The ethanolic extract of Lychnophora trichocarpha Spreng. is used in Brazilian folk medicine to treat bruise, pain and inflammatory diseases. AIM OF THE STUDY:The present study aimed at investigating whether ethanolic extract of L. trichocarpha, its ethyl acetate fraction and its main bi...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2012.06.012

    authors： de Souza MR,de Paula CA,Pereira de Resende ML,Grabe-Guimarães A,de Souza Filho JD,Saúde-Guimarães DA

    更新日期：2012-08-01 00:00:00

  • Identification and pharmacological characterization of the anti-inflammatory principal of the leaves of dwarf elder (Sambucus ebulus L.).

    abstract：AIM OF THE STUDY:The performed investigations aimed on the identification of the anti-inflammatory principal of extracts of leaves of Sambucus ebulus L. (dwarf elder) in order to rationalize the traditional use of this plant for the treatment of chronically inflammatory diseases. MATERIALS AND METHODS:Dwarf elder leaf...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2010.10.049

    authors： Schwaiger S,Zeller I,Pölzelbauer P,Frotschnig S,Laufer G,Messner B,Pieri V,Stuppner H,Bernhard D

    更新日期：2011-01-27 00:00:00

  • Forsythiae Fructuse water extract attenuates liver fibrosis via TLR4/MyD88/NF-κB and TGF-β/smads signaling pathways.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Forsythiae Fructuse water extract (FSE) is a water-soluble component extracted from the traditional Chinese medicine Forsythiae Fructuse (The fruit of Forsythia suspensa (Thunb.) Vahl) usually used to treat inflammatory diseases. However, little is known about the therapeutic effect of FS...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2020.113275

    authors： Hu N,Guo C,Dai X,Wang C,Gong L,Yu L,Peng C,Li Y

    更新日期：2020-11-15 00:00:00

  • Antidiabetic activity of alcoholic stem extract of Nervilia plicata in streptozotocin-nicotinamide induced type 2 diabetic rats.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Nervilia plicata (Orchidaceae) has long been used in the antidiabetic medicinal preparations of traditional healers of Wayanad (Kerala), but recuperative potential of the plant was remained undefined. We demonstrated the regenerative potential of the plant extract on kidney affected by ty...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2010.10.025

    authors： Kumar EK,Janardhana GR

    更新日期：2011-01-27 00:00:00

  • Phytochemical screening of a Warao pharmacopoeia employed to treat gastrointestinal disorders.

    abstract：:A three-year medical-ethnobotanical investigation among the Warao of the Orinoco Delta in eastern Venezuela documented a pharmacopoeia of 100 plant species representing 45 families. Warao phytotherapists manipulate these plants in diverse manners to produce 259 remedies of various complexities to treat 52 classes of d...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/0378-8741(91)90183-e

    authors： Wilbert W,Haiek G

    更新日期：1991-08-01 00:00:00

  • Ethnobotanical survey in the Palestinian area: a classification of the healing potential of medicinal plants.

    abstract：:An ethnobotanical survey was carried out in the West Bank to evaluate the relative efficacy of the plants used to treat skin diseases and prostate cancer. A total number of 102 informants, 30 years and older and either native born or had been living in the West Bank for more than 30 years, were interviewed using a pre...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/s0378-8741(00)00316-0

    authors： Ali-Shtayeh MS,Yaniv Z,Mahajna J

    更新日期：2000-11-01 00:00:00

  • Delayed ossification in Wistar rats induced by Morinda citrifolia L. exposure during pregnancy.

    abstract：UNLABELLED:Different products of plant Morinda citrifolia L. (noni) have been marketed and used around the world based on properties described by Polynesian people that use them for more than 2000 years. Marketing of these products is based on their presumptive phytotherapic properties. However there is little scientif...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2009.12.029

    authors： Marques NF,Marques AP,Iwano AL,Golin M,De-Carvalho RR,Paumgartten FJ,Dalsenter PR

    更新日期：2010-03-02 00:00:00

  • Antihepatotoxic actions of gingerols and diarylheptanoids.

    abstract：:The antihepatotoxic effects of gingerols, shogaols, diarylheptanoids and related analogues were assessed utilizing carbon tetrachloride- and galactosamine-induced cytotoxicity in primary cultured rat hepatocytes. Most congeners exhibited significant actions in these assay methods. The carbon tetrachloride assay appear...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/0378-8741(85)90025-x

    authors： Hikino H,Kiso Y,Kato N,Hamada Y,Shioiri T,Aiyama R,Itokawa H,Kiuchi F,Sankawa U

    更新日期：1985-09-01 00:00:00

  • Improvement of the liver pathology by the aqueous extract and the n-butanol fraction of Sida pilosa Retz in Schistosoma mansoni-infected mice.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Sida pilosa Retz (Malvaceae) is a plant used in Africa for the treatment of intestinal helminthiasis, lower abdominal pains and dysmenorrhea. AIM OF THE STUDY:In order to determine the potential use of S. pilosa in the treatment of schistosomiasis mansoni, we evaluated the schistosomicid...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2016.01.017

    authors： Jatsa HB,Russo RC,Pereira CA,Aguilar EC,Garcia CC,Araújo ES,Oliveira JL,Rodrigues VF,de Oliveira VG,Alvarez-Leite JI,Braga FC,Louis-Albert Tchuem Tchuente,Kamtchouing P,Negrão-Corrêa DA,Teixeira MM

    更新日期：2016-03-02 00:00:00

  • Anti-diarrheal activity of (-)-epicatechin from Chiranthodendron pentadactylon Larreat: experimental and computational studies.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Chiranthodendron pentadactylon Larreat is frequently used in Mexican traditional medicine as well as in Guatemalan for several medicinal purposes, including their use in the control of diarrhea. AIM OF THE STUDY:This work was undertaken to obtain additional information that support the t...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2012.07.039

    authors： Velázquez C,Correa-Basurto J,Garcia-Hernandez N,Barbosa E,Tesoro-Cruz E,Calzada S,Calzada F

    更新日期：2012-09-28 00:00:00

  • Free radical scavenging activity of the alcoholic extract of Trewia polycarpa roots in arthritic rats.

    abstract：:The alcoholic extract of Trewia polycarpa roots (TPE), which exhibited significant anti-inflammatory activity, was evaluated for the possible mode of action by studying its antioxidant potential in adjuvant-induced arthritic rats. The biological defence system constituting the superoxide dismutase, glutathione peroxid...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/s0378-8741(03)00143-0

    authors： Chamundeeswari D,Vasantha J,Gopalakrishnan S,Sukumar E

    更新日期：2003-09-01 00:00:00

  • Phytochemical constituents, distributions and traditional usages of Arnebia euchroma: a review.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:The present study has indicated phytochemical composition, distribution and ethno-medicinal uses of Arnebia euchroma (Royle) I.M. Johnst, which is commonly known as "Ratanjot" in the Indian subcontinent. It has widely been used in the traditional systems of the Unani, Ayurvedic and Chines...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jep.2021.113896

    authors： Kumar A,Shashni S,Kumar P,Pant D,Singh A,Verma RK

    更新日期：2021-01-29 00:00:00

  • A novel approach using metabolomics coupled with hematological and biochemical parameters to explain the enriching-blood effect and mechanism of unprocessed Angelica sinensis and its 4 kinds of processed products.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Angelica sinensis (AS), root of Angelica sinensis (Oliv.) Diels, an important kind of Chinese traditional herbal medicine, has been used for women to enrich the blood for thousands of years. It is mainly distributed in Gansu province of China. According to Traditional Chinese medicine usa...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2017.09.028

    authors： Ji P,Wei Y,Hua Y,Zhang X,Yao W,Ma Q,Yuan Z,Wen Y,Yang C

    更新日期：2018-01-30 00:00:00

  • In vitro cytotoxic, antileishmanial and antifungal activities of ethnopharmacologically selected Gabonese plants.

    abstract：:Seventy-seven crude extracts from leaves and stem barks of 15 Gabonese plants used in traditional medicine were evaluated for their cytotoxic, antileishmanial and antifungal activities. Most of the extracts exhibited cytotoxic activities toward human monocytes, and most particularly the hydromethanolic 50% (v/v) fract...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2005.06.011

    authors： Lamidi M,DiGiorgio C,Delmas F,Favel A,Eyele Mve-Mba C,Rondi ML,Ollivier E,Nze-Ekekang L,Balansard G

    更新日期：2005-11-14 00:00:00

  • Potential anthelmintic activity of Pelargonium endlicherianum Fenzl.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:The decoction prepared from the roots of Pelargonium endlicherianum Fenzl. has been used for the treatment of gastrointestinal parasitism in small ruminants in Turkish Folk Medicine. AIM OF THE STUDY:The aim of the present study is to investigate in vitro anthelmintic activity of the ext...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2016.04.044

    authors： Kozan E,Küpeli Akkol E,Süntar I

    更新日期：2016-07-01 00:00:00

  • Crude terpene glycoside component from Radix paeoniae rubra protects against isoproterenol-induced myocardial ischemic injury via activation of the PI3K/AKT/mTOR signaling pathway.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Radix paeoniae rubra, also known as chishao (CS), is a frequently used traditional Chinese medicine that can promote blood circulation to remove blood stasis. It has been widely used for the prevention and treatment of cardiovascular diseases in China. Although terpene glycoside (TG), the...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2017.05.028

    authors： Ke Z,Wang G,Yang L,Qiu H,Wu H,Du M,Chen J,Song J,Jia X,Feng L

    更新日期：2017-07-12 00:00:00

  • Effect of Acanthopanax senticosus stem on mast cell-dependent anaphylaxis.

    abstract：:We studied the effect of Acanthopanax senticosus stem (ACPS) on mast cell-dependent anaphylaxis. ACPS inhibited compound 48/80-induced systemic anaphylaxis at a dose of 1.0 g/kg by 50%. ACPS also inhibited passive cutaneous anaphylaxis reaction and histamine release from mast cells in a dose-dependent manner, respecti...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/s0378-8741(01)00403-2

    authors： Yi JM,Hong SH,Kim JH,Kim HK,Song HJ,Kim HM

    更新日期：2002-03-01 00:00:00

  • Evaluation of anti-amnesic effect of extracts of selected Ocimum species using in-vitro and in-vivo models.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Ocimum species are traditionally used for the treatment of anxiety, nerve pain, convulsions and a variety of neurodegenerative disorders. The present study was undertaken to evaluate the anti-amnesic effect of O. basilicum L., O. sanctum L. and O. gratissimum L. extracts using in-vitro an...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2016.10.026

    authors： Singh V,Kahol A,Singh IP,Saraf I,Shri R

    更新日期：2016-12-04 00:00:00

  • Anti-melanoma activity of Cynanchi atrati Radix is mediated by regulation of NF-kappa B activity and pro-apoptotic proteins.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Cynanchi atrati Radix has been traditionally prescribed for patients with inflammatory fever or chronic tumoral disorders. Melanoma is one of the most devastating cancer types, in which overexpression of nuclear factor kappa B (NF-κB) enables the cancer to survive without apoptosis. To id...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2014.02.037

    authors： Son SW,Kim HG,Han JM,Lee JS,Choi MK,Lee JS,Son CG

    更新日期：2014-04-11 00:00:00

  • Antimalarial activity of extracts of Malaysian medicinal plants.

    abstract：:In vitro and in vivo studies revealed that Malaysian medicinal plants, Piper sarmentosum, Andrographis paniculata and Tinospora crispa produced considerable antimalarial effects. Chloroform extract in vitro did show better effect than the methanol extract. The chloroform extract showed complete parasite growth inhibit...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/s0378-8741(98)00135-4

    authors： Najib Nik A Rahman N,Furuta T,Kojima S,Takane K,Ali Mohd M

    更新日期：1999-03-01 00:00:00