Synthesis and bioassay of improved mosquito repellents predicted from chemical structure.

abstract：:Drosophila melanogaster CRYPTOCHROME (CRY) mediates behavioral and electrophysiological responses to blue light coded by circadian and arousal neurons. However, spectroscopic and biochemical assays of heterologously expressed CRY suggest that CRY may mediate functional responses to UV-A (ultraviolet A) light as well. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Baik LS,Fogle KJ,Roberts L,Galschiodt AM,Chevez JA,Recinos Y,Nguy V,Holmes TC

更新日期：2017-01-24 00:00:00

abstract：:In rod photoreceptors, several phototransduction components display light-dependent translocation between cellular compartments. Notably, the G protein transducin translocates from rod outer segments to inner segments/spherules in bright light, but the functional consequences of translocation remain unclear. We genera...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Majumder A,Pahlberg J,Boyd KK,Kerov V,Kolandaivelu S,Ramamurthy V,Sampath AP,Artemyev NO

更新日期：2013-07-23 00:00:00

abstract：:mtDNA mutations occur in a wide variety of degenerative diseases and cancer. mtDNA seems to be more susceptible to DNA damage and consequently sustains higher rates of mutation than does nuclear DNA (nDNA). Many of the somatic mtDNA mutations in human cancers are located in the displacement loop (D-loop) and in partic...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mambo E,Gao X,Cohen Y,Guo Z,Talalay P,Sidransky D

更新日期：2003-02-18 00:00:00

abstract：:The members of the cytoplasmic 70-kDa heat shock protein family are involved in appropriate folding and trafficking of newly synthesized proteins in the cell. Hsc70, which is expressed constitutively, and Hsp70, the expression of which is stress- and heat shock-induced, are often considered to have similar cellular fu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Goldfarb SB,Kashlan OB,Watkins JN,Suaud L,Yan W,Kleyman TR,Rubenstein RC

更新日期：2006-04-11 00:00:00

abstract：:Three lines of evidence for abrupt tropical climate change, both past and present, are presented. First, annually and decadally averaged delta(18)O and net mass-balance histories for the last 400 and 2,000 yr, respectively, demonstrate that the current warming at high elevations in the mid- to low latitudes is unprece...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Thompson LG,Mosley-Thompson E,Brecher H,Davis M,León B,Les D,Lin PN,Mashiotta T,Mountain K

更新日期：2006-07-11 00:00:00

abstract：:A procedure for combined sequential affinity adsorption-electrophoresis has been devised. Its use for the rapid purification of a calcium-dependent cyclic nucleotide phosphodiesterase from bovine brain in high yield is described. In this procedure, proteins bound to a solid phase of calcium-dependent regulatory protei...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kincaid RL,Vaughan M

更新日期：1979-10-01 00:00:00

abstract：:The glycogen content of yeast rises dramatically just before the onset of the stationary phase of growth. Concomitantly, a rapid increase was found in the glucose 6-phosphate-independent (I) activity of glycogen synthetase, as well as in the total amount of enzyme. A mutant (GS 1-36) was obtained, which did not accumu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rothman-Denes LB,Cabib E

更新日期：1970-07-01 00:00:00

abstract：:Relying on a quantitative analysis of the patenting and assignment behavior of inventors, we highlight the evolution of institutions that encouraged trade in technology and a growing division of labor between those who invented new technologies and those who exploited them commercially over the nineteenth and early-tw...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lamoreaux NR,Sokoloff KL

更新日期：1996-11-12 00:00:00

abstract：:The imino sugar N-butyldeoxynojirimycin (NBDNJ) is a potent inhibitor of the oligosaccharide-trimming enzyme alpha-glucosidase I. Hepatitis B virus (HBV) contains three surface proteins (HBs proteins) of different sizes that are singly or doubly N-glycosylated and are essential for the formation of infectious virus. T...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Block TM,Lu X,Platt FM,Foster GR,Gerlich WH,Blumberg BS,Dwek RA

更新日期：1994-03-15 00:00:00

abstract：:Protein-based hydrogels have emerged as promising alternatives to synthetic hydrogels for biomedical applications, owing to the precise control of structure and function enabled by protein engineering. Nevertheless, strategies for assembling 3D molecular networks that carry the biological information encoded in full-l...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sun F,Zhang WB,Mahdavi A,Arnold FH,Tirrell DA

更新日期：2014-08-05 00:00:00

abstract：:13C-labeled precorrin-6x is biosynthesized by cell-free protein preparations from Pseudomonas denitrificans in separate experiments using delta-amino[5-13C]levulinic acid and the corresponding delta-amino[4-13C]- and delta-amino[3-13C]levulinic acid-labeled forms in conjunction with S-[methyl-13C]adenosylmethionine fo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Thibaut D,Blanche F,Debussche L,Leeper FJ,Battersby AR

更新日期：1990-11-01 00:00:00

abstract：:A defect in the yeast GEF1 gene, a CLC chloride channel homolog leads to an iron requirement and cation sensitivity. The iron requirement is due to a failure to load Cu2+ onto a component of the iron uptake system, Fet3. This process, which requires both Gef1 and the Menkes disease Cu2+-ATPase yeast homolog Ccc2, occu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gaxiola RA,Yuan DS,Klausner RD,Fink GR

更新日期：1998-03-31 00:00:00

abstract：:We have analyzed the level of intraindividual sequence variability (heteroplasmy) of mtDNA in human brain by denaturing gradient gel electrophoresis and sequencing. Single base substitutions, as well as insertions or deletions of single bases, were numerous in the noncoding control region (D-loop), and 35-45% of the m...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jazin EE,Cavelier L,Eriksson I,Oreland L,Gyllensten U

更新日期：1996-10-29 00:00:00

abstract：:Transforming growth factor betas (TGF-betas) regulate key aspects of embryonic development and major human diseases. Although Smad2, Smad3, and extracellular signal-regulated kinase (ERK) mitogen-activated protein kinases (MAPKs) have been proposed as key mediators in TGF-beta signaling, their functional specificities...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yang YC,Piek E,Zavadil J,Liang D,Xie D,Heyer J,Pavlidis P,Kucherlapati R,Roberts AB,Böttinger EP

更新日期：2003-09-02 00:00:00

abstract：:Two brefeldin A (BFA)-inhibited guanine nucleotide-exchange proteins for ADP-ribosylation factors, 200-kDa BIG1 and 190-kDa BIG2, were copurified from bovine brain cytosol associated with >670-kDa macromolecular complexes. When observed by immunofluorescence in HeLa S3 and HepG2 cells, endogenous BIG1 and coexpressed ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yamaji R,Adamik R,Takeda K,Togawa A,Pacheco-Rodriguez G,Ferrans VJ,Moss J,Vaughan M

更新日期：2000-03-14 00:00:00

abstract：:Two formal models of clonal attenuation [Kirkwood, T. B. L. & Holliday, R. (1975) J. Theor. Biol. 53, 481-496; Shall, S. & Stein, W. D. (1979) J. Theor. Biol. 76, 219-231] are considered in the light of recent data on the changing distribution of replicative potential among individual cultured fibroblasts on subclonin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Prothero J,Gallant JA

更新日期：1981-01-01 00:00:00

abstract：:Peroxisome proliferators (PP) induce a highly predictable pleiotropic response in rat and mouse liver that is characterized by hepatomegaly, increase in peroxisome number in hepatocytes, and induction of certain peroxisomal enzymes. The PP-binding protein (PPbP) was purified from rat liver cytosol by a two-step proced...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lalwani ND,Alvares K,Reddy MK,Reddy MN,Parikh I,Reddy JK

更新日期：1987-08-01 00:00:00

abstract：:Despite its theoretical prominence and sound principles, integrated pest management (IPM) continues to suffer from anemic adoption rates in developing countries. To shed light on the reasons, we surveyed the opinions of a large and diverse pool of IPM professionals and practitioners from 96 countries by using structur...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Parsa S,Morse S,Bonifacio A,Chancellor TC,Condori B,Crespo-Pérez V,Hobbs SL,Kroschel J,Ba MN,Rebaudo F,Sherwood SG,Vanek SJ,Faye E,Herrera MA,Dangles O

更新日期：2014-03-11 00:00:00

abstract：:Serum levels of apolipoprotein CIII (apoCIII) are increased in type 1 diabetic patients, and when β cells are exposed to these diabetic sera, apoptosis occurs, an effect abolished by an antibody against apoCIII. We have investigated the BB rat, an animal model that develops a human-like type 1 diabetes, and found that...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Holmberg R,Refai E,Höög A,Crooke RM,Graham M,Olivecrona G,Berggren PO,Juntti-Berggren L

更新日期：2011-06-28 00:00:00

abstract：:Studies of natural killer (NK) cell function in vivo have been challenging primarily due to the lack of animal models in which NK cells are genetically and selectively deficient. Here, we describe a transgenic mouse with defective natural killing and selective deficiency in NK1.1(+) CD3(-) cells. Despite functionally ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kim S,Iizuka K,Aguila HL,Weissman IL,Yokoyama WM

更新日期：2000-03-14 00:00:00

abstract：:The first crystal structure of the neurotransmitter/sodium symporter homolog LeuT revealed an occluded binding pocket containing leucine and 2 Na(+); later structures showed tricyclic antidepressants (TCAs) in an extracellular vestibule approximately 11 A above the bound leucine and 2 Na(+). We recently found this reg...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Quick M,Winther AM,Shi L,Nissen P,Weinstein H,Javitch JA

更新日期：2009-04-07 00:00:00

abstract：:The 8;21 translocation is one of the most common specific rearrangements in acute myelogenous leukemia. We have identified markers (D21S65 and a Not I boundary clone, Not-42, referred to as probe B) flanking the chromosome 21 translocation breakpoint (21q22.3) that demonstrate physical linkage in normal genomic DNA, b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gao J,Erickson P,Gardiner K,Le Beau MM,Diaz MO,Patterson D,Rowley JD,Drabkin HA

更新日期：1991-06-01 00:00:00

abstract：:Phagocytic cells are a critical line of defense against infection. The ability of a pathogen to survive and even replicate within phagocytic cells is a potent method of evading the defense mechanisms of the host. A number of pathogens survive within macrophages after phagocytosis and this contributes to their virulenc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lindgren SW,Stojiljkovic I,Heffron F

更新日期：1996-04-30 00:00:00

abstract：:Avian leukosis virus subgroup J (ALV-J) is an important concern for the poultry industry. Replication of ALV-J depends on a functional cellular receptor, the chicken Na+/H+ exchanger type 1 (chNHE1). Tryptophan residue number 38 of chNHE1 (W38) in the extracellular portion of this molecule is a critical amino acid for...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Koslová A,Trefil P,Mucksová J,Reinišová M,Plachý J,Kalina J,Kučerová D,Geryk J,Krchlíková V,Lejčková B,Hejnar J

更新日期：2020-01-28 00:00:00

abstract：:The effects of temperature and of the action of a purified phospholipase C enzyme preparation on human red blood cell membranes has been investigated by chemical analyses, circular dichroism, and proton magnetic resonance measurements. The results indicate that a substantial fraction of the phospholipids and the prote...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Glaser M,Simpkins H,Singer SJ,Sheetz M,Chan SI

更新日期：1970-03-01 00:00:00

abstract：:Cancer stem-like cells (CSCs) are a highly tumorigenic cell type present as a minority population in developmentally diverse tumors and cell lines. Using a genetic screen in an inducible model of CSC formation in a breast cell line, we identify microRNAs (miRNAs) that inhibit CSC growth and are down-regulated in CSCs....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Polytarchou C,Iliopoulos D,Struhl K

更新日期：2012-09-04 00:00:00

abstract：:Genetic analysis has revealed that the accumulation of several chloroplast mRNAs of the green alga Chlamydomonas reinhardtii requires specific nucleus-encoded functions. To gain insight into this process, we have cloned the nuclear gene encoding the Mbb1 factor by genomic rescue of a mutant specifically deficient in t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vaistij FE,Boudreau E,Lemaire SD,Goldschmidt-Clermont M,Rochaix JD

更新日期：2000-12-19 00:00:00

abstract：:Osmotic homeostasis in the brain involves movement of water through aquaporin-4 (AQP4) membrane channels. Perivascular astrocyte end-feet contain distinctive orthogonal lattices (square arrays) assembled from 4- to 6-nm intramembrane particles (IMPs) corresponding to individual AQP4 tetramers. Two isoforms of AQP4 res...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Furman CS,Gorelick-Feldman DA,Davidson KG,Yasumura T,Neely JD,Agre P,Rash JE

更新日期：2003-11-11 00:00:00

abstract：:The cell surface of embryonic peripheral neurons provides a mitogenic stimulus for Schwann cells. We report (i) the solubilization of this mitogenic activity from rat dorsal root ganglion neurons grown in tissue culture and (ii) the solubilization and partial purification of mitogenic activity from neonatal rat brains...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ratner N,Hong DM,Lieberman MA,Bunge RP,Glaser L

更新日期：1988-09-01 00:00:00

abstract：:Protein aggregation is a complex physiological process, primarily determined by stress-related factors revealing the hidden aggregation propensity of proteins that otherwise are fully soluble. Here we report a mechanism by which glycolytic glyceraldehyde-3-phosphate dehydrogenase of Arabidopsis thaliana (AtGAPC1) is p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zaffagnini M,Marchand CH,Malferrari M,Murail S,Bonacchi S,Genovese D,Montalti M,Venturoli G,Falini G,Baaden M,Lemaire SD,Fermani S,Trost P

更新日期：2019-12-17 00:00:00