CRYPTOCHROME mediates behavioral executive choice in response to UV light.

abstract：:We have cloned an additional member (GC-D) of the membrane receptor guanylyl cyclase [GTP pyrophosphate-lyase (cyclizing), EC 4.6.1.2] family that is specifically expressed in a subpopulation of olfactory sensory neurons. The extracellular, putative ligand-binding domain of the olfactory cyclase is similar in primary ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fülle HJ,Vassar R,Foster DC,Yang RB,Axel R,Garbers DL

更新日期：1995-04-11 00:00:00

abstract：:In previous papers of this series, emphasis has been placed on the steady-state phase transition and critical properties of large lattices of interacting, symmetrical, and identical enzyme molecules. The present paper is concerned with a number of examples of enzyme--enzyme interactions that do not belong to the class...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hill TL

更新日期：1978-03-01 00:00:00

abstract：:Transcriptional interference between genes and the regulatory elements of simple eukaryotes such as Saccharomyces cerevisiae is an unavoidable consequence of their compressed genetic arrangement. We have shown previously that with the tandem arranged genes GAL10 and GAL7, inefficient transcriptional termination of the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Prescott EM,Proudfoot NJ

更新日期：2002-06-25 00:00:00

abstract：:Fossil glycoproteins of the soluble organic matrix are present in an 80-million-year-old mollusk shell from the Late Cretaceous Period. Discrete molecular weight components, as determined by gel electrophoresis, are preserved. The fossil organic matrix was compared with the organic matrix of a living representative sp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Weiner S,Lowenstam HA,Hood L

更新日期：1976-08-01 00:00:00

abstract：:Thermodynamics and kinetics of the interaction between T cell receptor specific for cytomegalovirus peptide (TCR(CMV)) and its specific ligand, pp65-HLA-A*0201 complex, were studied by surface plasmon resonance and stopped-flow methods. In the latter measurements, fluorescence resonance energy transfer (FRET) between ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gakamsky DM,Lewitzki E,Grell E,Saulquin X,Malissen B,Montero-Julian F,Bonneville M,Pecht I

更新日期：2007-10-16 00:00:00

abstract：:We used 5,6-dichloro-beta D-ribofuranosyl-benzimidazole (DRB), a selective and reversible inhibitor of mRNA production, to investigate the regulation of the pathway leading to resistance to viruses in cells treated with interferon (IF). DRB allows initiation of transcription but promotes premature termination of the n...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gordon I,Stevenson D

更新日期：1980-01-01 00:00:00

abstract：:Brown adipose tissue (BAT) is present throughout life in rodents and plays an important role in energy balance. However, whereas BAT is clearly recognizable in the neonates of larger mammals (including dogs, cats, sheep, cattle, and humans), it is undetectable or present in only small quantities in adults of these spe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Champigny O,Ricquier D,Blondel O,Mayers RM,Briscoe MG,Holloway BR

更新日期：1991-12-01 00:00:00

abstract：:Invasive potentials of carcinomas greatly contribute to their metastasis, which is a major threat in most cancers. We have recently shown that Arf6 plays a pivotal role in breast cancer invasive activities and identified AMAP1 as an effector of GTP-Arf6 in invasion. Expression of AMAP1 correlates well with invasive ph...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hashimoto S,Hirose M,Hashimoto A,Morishige M,Yamada A,Hosaka H,Akagi K,Ogawa E,Oneyama C,Agatsuma T,Okada M,Kobayashi H,Wada H,Nakano H,Ikegami T,Nakagawa A,Sabe H

更新日期：2006-05-02 00:00:00

abstract：:An in vitro enzyme system for the conversion of amino acid to oxime in the biosynthesis of glucosinolates has been established by the combined use of an improved isolation medium and jasmonic acid-induced etiolated seedlings of Sinapis alba L. An 8-fold induction of de novo biosynthesis of the L-tyrosine-derived p-hyd...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Du L,Lykkesfeldt J,Olsen CE,Halkier BA

更新日期：1995-12-19 00:00:00

abstract：:Preclinical animal models have largely ignored the immune-suppressive mechanisms that are important in human cancers. The identification and use of such models should allow better predictions of successful human responses to immunotherapy. As a model for changes induced in nonmalignant cells by cancer, we examined T-c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gorgun G,Ramsay AG,Holderried TA,Zahrieh D,Le Dieu R,Liu F,Quackenbush J,Croce CM,Gribben JG

更新日期：2009-04-14 00:00:00

abstract：:The genomic RNA of the avian influenza A virus, fowl plague, was fractionated into eight species by electrophoresis in polyacrylamide-agarose gels containing 6 M urea. The separated 32P-labeled RNA species were characterized by digestion with RNase T1 and fractionation of the resulting oligonucleotides by two-dimensio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McGeoch D,Fellner P,Newton C

更新日期：1976-09-01 00:00:00

abstract：:Bacteriophage lambda integrates into the chromosome of its Escherichia coli host by means of a site-specific recombination between a locus on the phage chromosome (phage att site) and a locus on the bacterial chromosome (bacterial att site). The nucleotide sequence of four lambda att sites altered in site-specific rec...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hoess RH,Landy A

更新日期：1978-11-01 00:00:00

abstract：:Endogenous circadian rhythms have been described in a wide range of organisms from prokaryotes to man. Although basic circadian mechanisms at the molecular level are genetically fixed, certain properties of circadian rhythms at the organismic level can be modified by environmental conditions and subsequently retained ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brandstätter R,Kumar V,Abraham U,Gwinner E

更新日期：2000-10-24 00:00:00

abstract：:We report that oxytocin (Oxt) receptors (Oxtrs), on stimulation by the ligand Oxt, translocate into the nucleus of osteoblasts, implicating this process in the action of Oxt on osteoblast maturation. Sequential immunocytochemistry of intact cells or isolated nucleoplasts stripped of the outer nuclear membrane showed p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Di Benedetto A,Sun L,Zambonin CG,Tamma R,Nico B,Calvano CD,Colaianni G,Ji Y,Mori G,Grano M,Lu P,Colucci S,Yuen T,New MI,Zallone A,Zaidi M

更新日期：2014-11-18 00:00:00

abstract：:Although prostate cancer (CaP) is the most frequently diagnosed malignant tumor and the second leading cause of cancer deaths in American men, the mechanisms explaining the development and progression of CaP remain largely unknown. Recent studies have shown that some aberrantly expressed microRNAs (miRNAs) are involve...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shi XB,Xue L,Yang J,Ma AH,Zhao J,Xu M,Tepper CG,Evans CP,Kung HJ,deVere White RW

更新日期：2007-12-11 00:00:00

abstract：:Stable isotope values of carbon (delta13C) and nitrogen (delta15N) in blood, feathers, eggshell, and bone have been used in seabird studies since the 1980s, providing a valuable source of information on diet, foraging patterns, and migratory behavior in these birds. These techniques can also be applied to fossil mater...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Emslie SD,Patterson WP

更新日期：2007-07-10 00:00:00

abstract：:A number of studies have noted that nucleotide substitution rates at the chloroplast-encoded rbcL locus violate the molecular clock principle. Substitution rate variation at this plastid gene is particularly pronounced between palms and grasses; for example, a previous study estimated that substitution rates in rbcL s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gaut BS,Morton BR,McCaig BC,Clegg MT

更新日期：1996-09-17 00:00:00

abstract：:Functional lysosomes mediate autophagy and macropinocytosis for nutrient acquisition. Pancreatic ductal adenocarcinoma (PDAC) tumors exhibit high basal lysosomal activity, and inhibition of lysosome function suppresses PDAC cell proliferation and tumor growth. However, the codependencies induced by lysosomal inhibitio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Elliott IA,Dann AM,Xu S,Kim SS,Abt ER,Kim W,Poddar S,Moore A,Zhou L,Williams JL,Capri JR,Ghukasyan R,Matsumura C,Tucker DA,Armstrong WR,Cabebe AE,Wu N,Li L,Le TM,Radu CG,Donahue TR

更新日期：2019-04-02 00:00:00

abstract：:Lost myelin can be replaced after injury or during demyelinating diseases in a regenerative process called remyelination. In the central nervous system (CNS), the myelin sheaths, which protect axons and allow the fast propagation of electrical impulses, are produced by oligodendrocytes. The abundance and widespread di...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bielecki B,Mattern C,Ghoumari AM,Javaid S,Smietanka K,Abi Ghanem C,Mhaouty-Kodja S,Ghandour MS,Baulieu EE,Franklin RJ,Schumacher M,Traiffort E

更新日期：2016-12-20 00:00:00

abstract：:The role of the serum proteolytic system plasminogen/plasminogen activator as a biochemical tool used by the glia or neurons, or both, for maintaining their temporary and flexible cellular interactions during histogenesis of the nervous system is under study. The present report identifies a glia cell type, the Schwann...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kalderon N

更新日期：1984-11-01 00:00:00

abstract：:It has been a widely accepted hypothesis that the molecular clock slows down during evolution of higher primates. By molecular cloning and nucleotide sequence comparison of a rhesus macaque alpha-globin gene to its homologs in man, orangutan, olive baboon, and other mammals, we demonstrate a burst of evolution of the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shaw JP,Marks J,Shen CC,Shen CK

更新日期：1989-02-01 00:00:00

abstract：:Mammalian DAI (DNA-dependent activator of IFN-regulatory factors), an activator of the innate immune response, senses cytosolic DNA by using 2 N-terminal Z-DNA binding domains (ZBDs) and a third putative DNA binding domain located next to the second ZBD. Compared with other previously known ZBDs, the second ZBD of hum...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ha SC,Kim D,Hwang HY,Rich A,Kim YG,Kim KK

更新日期：2008-12-30 00:00:00

abstract：:Gene expression has a stochastic component because of the single-molecule nature of the gene and the small number of copies of individual DNA-binding proteins in the cell. We show how the statistics of such systems can be mapped onto quantum many-body problems. The dynamics of a single gene switch resembles the spin-b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sasai M,Wolynes PG

更新日期：2003-03-04 00:00:00

abstract：:The regulation of the photosynthetic genes by DNA supercoiling in Rhodobacter capsulatus has been studied by using gyrase inhibitors in vivo and by measurement of mRNA levels of more than a dozen genes. The results demonstrate that the levels of mRNA for light-harvesting (I, II) and reaction center (L, M, H) proteins,...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhu YS,Hearst JE

更新日期：1988-06-01 00:00:00

abstract：:The main sources of information regarding ancient Mesopotamian history and culture are clay cuneiform tablets. Many of these tablets are damaged, leading to missing information. Currently, the missing text is manually reconstructed by experts. We investigate the possibility of assisting scholars, by modeling the langu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fetaya E,Lifshitz Y,Aaron E,Gordin S

更新日期：2020-09-15 00:00:00

abstract：:The prion protein (PrP) is a scrapie-associated fibril protein that accumulates in the brains of hamsters and mice infected with the scrapie agent, and also in the brains of persons affected with kuru or Creutzfeldt-Jakob disease. It has been previously proposed that PrP could be either the primary transmissible agent...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Locht C,Chesebro B,Race R,Keith JM

更新日期：1986-09-01 00:00:00

abstract：:The amino-acid sequence of the gamma-carboxyglutamic acid-containing protein of bovine bone is presented. The sequence of 43 of the 49 residues was determined automatically on the intact protein and on a tryptic peptide. The remainder was determined by conventional procedures on tryptic and chymotrytic peptides. Resid...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Price PA,Poser JW,Raman N

更新日期：1976-10-01 00:00:00

abstract：:Neurotrophins are potent survival factors for developing and injured neurons. However, they are not being used to treat neurodegenerative diseases because of difficulties in administration and numerous side effects that have been encountered in previous clinical trials. Their biological activities use Trk (tropomyosin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wiese S,Jablonka S,Holtmann B,Orel N,Rajagopal R,Chao MV,Sendtner M

更新日期：2007-10-23 00:00:00

abstract：:We have noted consistent structural similarities among unrelated proteases. In comparison with other proteins of similar size, proteases have smaller than average surface areas, smaller radii of gyration, and higher C(alpha) densities. These findings imply that proteases are, as a group, more tightly packed than other...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stawiski EW,Baucom AE,Lohr SC,Gregoret LM

更新日期：2000-04-11 00:00:00

abstract：:Pbx-regulating protein-1 (Prep1) is a tumor suppressor, whereas myeloid ecotropic viral integration site-1 (Meis1) is an oncogene. We show that, to perform these activities in mouse embryonic fibroblasts, both proteins competitively heterodimerize with pre-B-cell leukemia homeobox-1 (Pbx1). Meis1 alone transforms Prep...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dardaei L,Longobardi E,Blasi F

更新日期：2014-03-11 00:00:00