Abstract:
:The amino-acid sequence of the gamma-carboxyglutamic acid-containing protein of bovine bone is presented. The sequence of 43 of the 49 residues was determined automatically on the intact protein and on a tryptic peptide. The remainder was determined by conventional procedures on tryptic and chymotrytic peptides. Residue 9 in the sequence has been identified as 4-hydroxyproline. The protein contains three gamma-carboxyglutamic acid residues, which are located at positions 17, 21, and 24. The role of these unusual amino acids in the binding interaction between the protein and hydroxyapatite crystals is discussed.
journal_name
Proc Natl Acad Sci U S Aauthors
Price PA,Poser JW,Raman Ndoi
10.1073/pnas.73.10.3374keywords:
subject
Has Abstractpub_date
1976-10-01 00:00:00pages
3374-5issue
10eissn
0027-8424issn
1091-6490journal_volume
73pub_type
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