Restoration of fragmentary Babylonian texts using recurrent neural networks.

abstract：:Assembly of protein complexes is a key mechanism for achieving spatial and temporal coordination in processes involving many enzymes. Growth of rod-shaped bacteria is a well-studied example requiring such coordination; expansion of the cell wall is thought to involve coordination of the activity of synthetic enzymes w...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lee TK,Tropini C,Hsin J,Desmarais SM,Ursell TS,Gong E,Gitai Z,Monds RD,Huang KC

更新日期：2014-03-25 00:00:00

abstract：:Several lines of evidence suggest that the mixed lineage leukemia protein (MLL, ALL-1, HRX) plays a role in regulating myelomonocytic differentiation. In this study we examined the effect of expression of MLL-AF9 on differentiation of the monoblastic U937 cell line by using a tetracycline-inducible expression system. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Caslini C,Shilatifard A,Yang L,Hess JL

更新日期：2000-03-14 00:00:00

abstract：:Activation of protein kinase C (PKC) by phorbol ester facilitates hormonal secretion and transmitter release, and phorbol ester-induced synaptic potentiation (PESP) is a model for presynaptic facilitation. A variety of PKC isoforms are expressed in the central nervous system, but the isoform involved in the PESP has n...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Saitoh N,Hori T,Takahashi T

更新日期：2001-11-20 00:00:00

abstract：:cDNA array technology has proven to be a powerful way to monitor global changes in gene expression patterns. Here, we present an approach that extends the current utility of cDNA arrays to allow the evaluation of the relative roles of transcription and mRNA turnover in governing gene expression on a global basis, comp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fan J,Yang X,Wang W,Wood WH 3rd,Becker KG,Gorospe M

更新日期：2002-08-06 00:00:00

abstract：:Natural products have long served as both a source and inspiration for pharmaceuticals. Modifying the structure of a natural product often improves the biological activity of the compound. Metabolic engineering strategies to ferment "unnatural" products have been enormously successful in microbial organisms. However, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Runguphan W,Maresh JJ,O'Connor SE

更新日期：2009-08-18 00:00:00

abstract：:Human mammary epithelial cells secrete and express on their cell surfaces complex mucin glycoproteins (Mr greater than 250,000) that are developmentally regulated, tumor-associated, and highly immunogenic. Studies using monoclonal antibodies directed to these glycoproteins suggest that their molecular structures can v...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gendler SJ,Burchell JM,Duhig T,Lamport D,White R,Parker M,Taylor-Papadimitriou J

更新日期：1987-09-01 00:00:00

abstract：:The endodermis acts as a "second skin" in plant roots by providing the cellular control necessary for the selective entry of water and solutes into the vascular system. To enable such control, Casparian strips span the cell wall of adjacent endodermal cells to form a tight junction that blocks extracellular diffusion ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hosmani PS,Kamiya T,Danku J,Naseer S,Geldner N,Guerinot ML,Salt DE

更新日期：2013-08-27 00:00:00

abstract：:To explore the pathogenic mechanism of dominant mutations affecting the carboxyl terminus of rhodopsin that cause retinitis pigmentosa, we generated five lines of transgenic mice carrying the proline-347 to serine (P347S) mutation. The severity of photoreceptor degeneration correlated with the levels of transgene expr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li T,Snyder WK,Olsson JE,Dryja TP

更新日期：1996-11-26 00:00:00

abstract：:Maintaining the fidelity of nascent peptide chain (NP) synthesis is essential for proteome integrity and cellular health. Ribosome-associated quality control (RQC) serves to resolve stalled translation, during which untemplated Ala/Thr residues are added C terminally to stalled peptide, as shown during C-terminal Ala ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li S,Wu Z,Tantray I,Li Y,Chen S,Dong J,Glynn S,Vogel H,Snyder M,Lu B

更新日期：2020-10-06 00:00:00

abstract：:The release of catecholamines from adrenal chromaffin cells is known to be blocked by dihydropyridines, such as nitrendipine, and enhanced by others, such as BAY K8644. On the other hand, release from sympathetic neurons is predominantly insensitive to these agents. Release of [3H]norepinephrine from undifferentiated ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kongsamut S,Miller RJ

更新日期：1986-04-01 00:00:00

abstract：:Amplitude-modulated phosphorescence/microwave double-resonance (AM-PMDR) spectra are reported for complexes of methylmercury(II) cation, designated CH3Hg(II), with tryptophan and glyceraldehyde-3-phosphate dehydrogenase (GPDHase; from rabbit muscle). Wavelength shifts are observed in the AM-PMDR spectra of CH3Hg(II)-t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Davis JM,Maki AH

更新日期：1982-07-01 00:00:00

abstract：:Ribosomal RNA (rRNA) genes are down-regulated during osteogenesis, myogenesis, and adipogenesis, necessitating a mechanistic understanding of interrelationships between growth control and phenotype commitment. Here, we show that cell fate-determining factors [MyoD, myogenin (Mgn), Runx2, C/EBPbeta] occupy rDNA loci an...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ali SA,Zaidi SK,Dacwag CS,Salma N,Young DW,Shakoori AR,Montecino MA,Lian JB,van Wijnen AJ,Imbalzano AN,Stein GS,Stein JL

更新日期：2008-05-06 00:00:00

abstract：:The in vitro biological activities of several rabies virus-neutralizing monoclonal antibodies (mAbs) were compared with their ability to prevent a lethal rabies virus encephalomyelitis. The protective activity of a particular mAb in vivo did not correlate with its virus-neutralizing activity in vitro; rather it was re...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dietzschold B,Kao M,Zheng YM,Chen ZY,Maul G,Fu ZF,Rupprecht CE,Koprowski H

更新日期：1992-08-01 00:00:00

abstract：:We have used oligonucleotide-directed mutagenesis to make a specific change in the beta-lactamase (EC 3.5.2.6) (ampicillin resistance) gene of the plasmid pBR322. Evidence suggests that the active site for this enzyme may include a serine-threonine dyad (residues 70 and 71). By priming in vitro DNA synthesis with a ch...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dalbadie-McFarland G,Cohen LW,Riggs AD,Morin C,Itakura K,Richards JH

更新日期：1982-11-01 00:00:00

abstract：:Pulmonary pathologies including adult respiratory distress syndrome are characterized by disruption of pulmonary integrity and edema compromising respiratory function. Sphingosine 1-phosphate (S1P) is a lipid mediator synthesized and/or stored in mast cells, platelets, and epithelial cells, with production up-regulate...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gon Y,Wood MR,Kiosses WB,Jo E,Sanna MG,Chun J,Rosen H

更新日期：2005-06-28 00:00:00

abstract：:High-pressure methods are increasingly used to produce new dense materials with unusual properties. Increasing efforts to understand the reaction mechanisms at the microscopic level, to set up and optimize synthetic approaches, are currently directed at carbon-based solids. A fundamental, but still unsolved, question ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Citroni M,Bini R,Foggi P,Schettino V

更新日期：2008-06-03 00:00:00

abstract：:The amyloid beta-protein precursor (AbetaPP) is best known as the parent molecule to the amyloid beta-peptide that accumulates in the brains of patients with Alzheimer's disease. Secreted isoforms of AbetaPP that contain the Kunitz proteinase inhibitor domain are analogous to the previously identified cell-secreted pr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xu F,Davis J,Miao J,Previti ML,Romanov G,Ziegler K,Van Nostrand WE

更新日期：2005-12-13 00:00:00

abstract：:Ride-sharing services are transforming urban mobility by providing timely and convenient transportation to anybody, anywhere, and anytime. These services present enormous potential for positive societal impacts with respect to pollution, energy consumption, congestion, etc. Current mathematical models, however, do not...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Alonso-Mora J,Samaranayake S,Wallar A,Frazzoli E,Rus D

更新日期：2017-01-17 00:00:00

abstract：:The preliminary structural characterization of a reversible ferrous dioxygen complex is reported. Mono(N-methyl imidazole) (dioxygen) meso-tetra (alpha,alpha,alpha,alpha-o-pivalamidephenyl) porphinatorino(II), [Fe(O(2))-(N-Me imid) (alpha,alpha,alpha,alpha-TpivPP)], 1, isolated from toluene solution, crystallizes in t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Collman JP,Gagne RR,Reed CA,Robinson WT,Rodley GA

更新日期：1974-04-01 00:00:00

abstract：:The mechanisms for plant growth restriction during stress conditions remains unclear. Here, we demonstrate that a phytochrome-interacting factor-like protein, OsPIL1/OsPIL13, acts as a key regulator of reduced internode elongation in rice under drought conditions. The level of OsPIL1 mRNA in rice seedlings grown under...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Todaka D,Nakashima K,Maruyama K,Kidokoro S,Osakabe Y,Ito Y,Matsukura S,Fujita Y,Yoshiwara K,Ohme-Takagi M,Kojima M,Sakakibara H,Shinozaki K,Yamaguchi-Shinozaki K

更新日期：2012-09-25 00:00:00

abstract：:The concept of contagion has steadily expanded from its original grounding in epidemic disease to describe a vast array of processes that spread across networks, notably social phenomena such as fads, political opinions, the adoption of new technologies, and financial decisions. Traditional models of social contagion ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ugander J,Backstrom L,Marlow C,Kleinberg J

更新日期：2012-04-17 00:00:00

abstract：:A rat model of hereditary renal carcinoma (RC) was found in a rat colony of the Sprague-Dawley strain in Japan and named the "Nihon" rat. In heterozygotes, RCs, predominantly the clear cell type, develop from early preneoplastic lesions, which began to appear as early as 3 weeks of age, to adenocarcinomas by the age o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Okimoto K,Sakurai J,Kobayashi T,Mitani H,Hirayama Y,Nickerson ML,Warren MB,Zbar B,Schmidt LS,Hino O

更新日期：2004-02-17 00:00:00

abstract：:Insects impact human health through vector-borne diseases and cause major economic losses by damaging crops and stored agricultural products. Insect-specific growth regulators represent attractive control agents because of their safety to the environment and humans. We identified plant compounds that serve as juvenile...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lee SH,Oh HW,Fang Y,An SB,Park DS,Song HH,Oh SR,Kim SY,Kim S,Kim N,Raikhel AS,Je YH,Shin SW

更新日期：2015-02-10 00:00:00

abstract：:In an earlier paper, the author jointly with S. Suryawanshi proposed statistical analysis of shape through triangulation of landmarks on objects. It was observed that the angles of the triangles are invariant to scaling, location, and rotation of objects. No distinction was made between an object and its reflection. T...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rao CR

更新日期：2000-03-28 00:00:00

abstract：:Hematopoietic stem/progenitor cells (HSPCs) possess the potentials of self-renewal, proliferation, and differentiation toward different lineages of blood cells. These cells not only play a primordial role in hematopoietic development but also have important clinical application. Characterization of the gene expression...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mao M,Fu G,Wu JS,Zhang QH,Zhou J,Kan LX,Huang QH,He KL,Gu BW,Han ZG,Shen Y,Gu J,Yu YP,Xu SH,Wang YX,Chen SJ,Chen Z

更新日期：1998-07-07 00:00:00

abstract：:Opioid receptors are differentially coupled to ion channels. Mu- and delta-opioid receptors are coupled to calcium- and/or voltage-dependent potassium channels and kappa-opioid receptors are coupled to voltage-dependent calcium channels. Using the single-electrode voltage-clamp technique, we investigated the effect of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gross RA,Macdonald RL

更新日期：1987-08-01 00:00:00

abstract：:After more than a decade of experiments generating and studying the physics of quantized vortices in atomic gas Bose-Einstein condensates, research is beginning to focus on the roles of vortices in quantum turbulence, as well as other measures of quantum turbulence in atomic condensates. Such research directions have ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： White AC,Anderson BP,Bagnato VS

更新日期：2014-03-25 00:00:00

abstract：:Integrins contain two structurally homologous but distantly related domains: an I-like domain that is present in all beta-subunits and an I domain that is present in some alpha-subunits. Atomic resolution and mutagenesis studies of alpha I domains demonstrate a C-terminal, axial displacement of the alpha7-helix that a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yang W,Shimaoka M,Chen J,Springer TA

更新日期：2004-02-24 00:00:00

abstract：:Fibrodysplasia ossificans progressiva (FOP) patients carry a missense mutation in ACVR1 [617G > A (R206H)] that leads to hyperactivation of BMP-SMAD signaling. Contrary to a previous study, here we show that FOP fibroblasts showed an increased efficiency of induced pluripotent stem cell (iPSC) generation. This positiv...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hayashi Y,Hsiao EC,Sami S,Lancero M,Schlieve CR,Nguyen T,Yano K,Nagahashi A,Ikeya M,Matsumoto Y,Nishimura K,Fukuda A,Hisatake K,Tomoda K,Asaka I,Toguchida J,Conklin BR,Yamanaka S

更新日期：2016-11-15 00:00:00

abstract：:Examples of finite-dimensional Hopf algebras over a field, whose antipodes have arbitrary even orders >/=4 as mappings, are furnished. The dimension of the Hopf algebra is q(n+1), where the antipode has order 2q, q >/= 2, and n is an arbitrary positive integer. The algebras are not semisimple, and neither they nor the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Taft EJ

更新日期：1971-11-01 00:00:00