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Identification of plant compounds that disrupt the insect juvenile hormone receptor complex.

Abstract：

:Insects impact human health through vector-borne diseases and cause major economic losses by damaging crops and stored agricultural products. Insect-specific growth regulators represent attractive control agents because of their safety to the environment and humans. We identified plant compounds that serve as juvenile hormone antagonists (PJHANs). Using the yeast two-hybrid system transformed with the mosquito JH receptor as a reporter system, we demonstrate that PJHANs affect the JH receptor, methoprene-tolerant (Met), by disrupting its complex with CYCLE or FISC, formation of which is required for mediating JH action. We isolated five diterpene secondary metabolites with JH antagonist activity from two plants: Lindera erythrocarpa and Solidago serotina. They are effective in causing mortality of mosquito larvae at relatively low LD50 values. Topical application of two diterpenes caused reduction in the expression of Met target genes and retardation of follicle development in mosquito ovaries. Hence, the newly discovered PJHANs may lead to development of a new class of safe and effective pesticides.

journal_name

Proc Natl Acad Sci U S A

journal_title

Proceedings of the National Academy of Sciences of the United States of America

authors

Lee SH,Oh HW,Fang Y,An SB,Park DS,Song HH,Oh SR,Kim SY,Kim S,Kim N,Raikhel AS,Je YH,Shin SW

doi

10.1073/pnas.1424386112

subject

Has Abstract

pub_date

2015-02-10 00:00:00

pages

1733-8

issue

6

eissn

0027-8424

issn

1091-6490

pii

1424386112

journal_volume

112

pub_type

杂志文章

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