Molecular testing for somatic mutations in common cancers: the views of UK oncologists.

abstract：BACKGROUND:Cardiac remodelling after acute myocardial infarction (AMI) is characterised by molecular and cellular mechanisms involving both left and right ventricles, and biventricular failure identifies patients with an extremely unfavourable prognosis. AIMS:To assess whether a link exists between increased myocardia...

journal_title：Journal of clinical pathology

authors： Bussani R,Abbate A,Biondi-Zoccai GG,Dobrina A,Leone AM,Camilot D,Di Marino MP,Baldi F,Silvestri F,Biasucci LM,Baldi A

更新日期：2003-09-01 00:00:00

abstract：:This memorandum proposes a standardized system of reporting the histology of human lymph nodes based on commonly used simple staining techniques. The purpose is to provide a uniform, internationally acceptable system by which the histological structure of lymph nodes can be correlated with other parameters of immunolo...

journal_title：Journal of clinical pathology

authors： Cottier H,Turk J,Sobin L

更新日期：1973-05-01 00:00:00

abstract：BACKGROUND:Although Bulgaria has one of the highest rates of cervical cancer incidence and mortality in the EU, data on HPV type distribution are limited. AIM:To determine the prevalence of HPV types 16 and 18 in archival specimens from cervical cancer cases from Bulgaria. METHODS:A total of 145 formalin-fixed, paraf...

journal_title：Journal of clinical pathology

authors： Todorova I,Ganchev G,Shikova E

更新日期：2010-12-01 00:00:00

abstract：BACKGROUND:Clinical outcome in patients with diffuse large B cell lymphomas (DLBCL) is highly variable and poorly predictable. Microarray studies showed that patients with DLBCL with a germinal centre B cell-like (GCB) phenotype have a better prognosis than those with an activated B cell-like (ABC) phenotype. The BMI1 ...

journal_title：Journal of clinical pathology

authors： van Galen JC,Muris JJ,Oudejans JJ,Vos W,Giroth CP,Ossenkoppele GJ,Otte AP,Raaphorst FM,Meijer CJ

更新日期：2007-02-01 00:00:00

abstract：:A 45-year-old female patient underwent right hemihepatectomy for metastatic rectal adenocarcinoma. Preoperative imaging demonstrated an area of focal nodular hyperplasia (FNH) in segment VIII and metastatic carcinoma in segment VI of the liver. Gross and microscopic examination of the former lesion showed features typ...

journal_title：Journal of clinical pathology

authors： Nisar PJ,Zaitoun AM,Damera A,Hodi Z,Tierney GM,Beckingham IJ

更新日期：2002-12-01 00:00:00

abstract：:The T(4)-free thyroxine index was used as the thyroid function test of first choice in a district general hospital for one year. Ninety-two patients were assessed both initially and at follow up by a single physician. The index agreed with clinical assessment in 69 out of 74 patients in whom diagnosis was unequivocal....

journal_title：Journal of clinical pathology

authors： Howorth PJ,Ward RL

更新日期：1972-03-01 00:00:00

abstract：:A saccharogenic method is described for estimating amylase activity in human urine. Results accord with those reported elsewhere except that in this study the peak in the beta zone is a new finding. Comparison between normal and pathological urines suggests that the amylase activity of the beta peak is not of pancreat...

journal_title：Journal of clinical pathology

authors： Franzini C

更新日期：1965-09-01 00:00:00

abstract：:Lymphocyte-depleted classical Hodgkin lymphoma (LDCHL) is the rarest entity among the classical Hodgkin lymphoma (CHL) subtypes, accounting for <1% of CHL cases in Western countries. Similarly, primary splenic Hodgkin lymphoma is a rare diagnosis among all cases of lymphomatous involvement of spleen. Representing a co...

journal_title：Journal of clinical pathology

authors： Parekh V,Peker D

更新日期：2015-11-01 00:00:00

abstract：:In vitro morphological and functional studies were carried out on platelets which had been cryopreserved in the presence of 5% dimethyl sulphoxide (DMSO). Overall loss of platelets was around 50%. Those which survived freezing and reconstitution showed marked morphological deterioration, increase of procoagulant activ...

journal_title：Journal of clinical pathology

authors： Baythoon H,Tuddenham EG,Hutton RA

更新日期：1982-08-01 00:00:00

abstract：:Using a short series of biochemical tests already in use in many routine laboratories, it is possible to identify strains of the genus Klebsiella and to differentiate K. aerogenes from other types. Marked production of slime is not peculiar to the group and colonial appearance alone is not a satisfactory basis for ide...

journal_title：Journal of clinical pathology

authors： DARRELL JH,HURDLE AD

更新日期：1964-11-01 00:00:00

abstract：:Foveolar dysplasia is an uncommon form of dysplasia that is encountered in the stomach and oesophagus in the context of Barrett’s oesophagus. Glands displaying foveolar dysplasia also show architectural abnormalities that are similar to those encountered in adenomatous dysplasia. However, from a cytological point of v...

journal_title：Journal of clinical pathology

authors： Serra S,Chetty R

更新日期：2014-10-01 00:00:00

abstract：AIMS:To evaluate aspects of the current practice of sentinel lymph node (SLN) pathology in breast cancer via a questionnaire based survey, to recognise major issues that the European guidelines for mammography screening should address in the next revision. METHODS:A questionnaire was circulated by mail or electronical...

journal_title：Journal of clinical pathology

authors： Cserni G,Amendoeira I,Apostolikas N,Bellocq JP,Bianchi S,Boecker W,Borisch B,Connolly CE,Decker T,Dervan P,Drijkoningen M,Ellis IO,Elston CW,Eusebi V,Faverly D,Heikkila P,Holland R,Kerner H,Kulka J,Jacquemier J,La

更新日期：2004-07-01 00:00:00

abstract：:Histological assessment of melanocytic naevi constitutes a substantial proportion of a dermatopathologist's daily workload. Although they may be excised for cosmetic reasons, most lesions encountered are clinically atypical and are biopsied or excised to exclude melanoma. Although dysplastic naevi are most often encou...

journal_title：Journal of clinical pathology

authors： Culpepper KS,Granter SR,McKee PH

更新日期：2004-11-01 00:00:00

abstract：:Electron microscopical and cytochemical studies of intestinal biopsies from a patient with typical features of the Cronkhite-Canada syndrome show that the primary process affects the crypts. This results in cystic dilatation associated with expansion and focal degeneration of the crypt compartment of the intestinal ep...

journal_title：Journal of clinical pathology

authors： Jenkins D,Stephenson PM,Scott BB

更新日期：1985-03-01 00:00:00

abstract：:The congenital dyserythropoietic anaemias (CDAs) are a group of rare hereditary disorders characterised by ineffective erythropoiesis and morphological abnormalities in the erythroblasts. Patients may present with jaundice or with symptoms of anaemia, gall stones or iron overload. The diagnosis can be challenging and ...

journal_title：Journal of clinical pathology

authors： Dukka S,King MJ,Hill QA

更新日期：2014-04-01 00:00:00

abstract：:Rapid diagnoses were made on 510 breast lumps by three methods in sequence and the results compared with those obtained by paraffin histology.Naked-eye examination of the excised lumps correctly distinguished between benign and malignant tumours in 95.1% of cases with 23 (4.5%) false negative and two (0.4%) false posi...

journal_title：Journal of clinical pathology

authors： Tribe CR

更新日期：1973-04-01 00:00:00

abstract：:In-vivo studies of fibrinogen metabolism were carried out using an I-120 labelled preparation of fibrinogen supplied commercially by the Radiochemical Centre, Amerhsham for use in the diagnosis of deep venous thrombosis. These studies show that the material is suitable for obtaining the main metabolic parameters of c...

journal_title：Journal of clinical pathology

authors： Bradley J,Hickman JA

更新日期：1975-06-01 00:00:00

abstract：AIMS:To describe the prostatic adenectomy specimens of six patients with symptomatic benign prostatic hyperplasia (BPH) who failed to respond to long term treatment with a 5-alpha-reductase inhibitor, finasteride. METHODS:Histological sections from six cases of BPH who had been treated with finasteride were investigat...

journal_title：Journal of clinical pathology

authors： Montironi R,Valli M,Fabris G

更新日期：1996-04-01 00:00:00

abstract：:A comprehensive neuropathological study was undertaken on 87 children aged between 2 and 15 years with fatal head injuries to identify those features which occurred at the time of head injury (fractured skull, contusions, intracranial haematoma and diffuse axonal injury) and those which were subsequently produced by c...

journal_title：Journal of clinical pathology

authors： Graham DI,Ford I,Adams JH,Doyle D,Lawrence AE,McLellan DR,Ng HK

更新日期：1989-01-01 00:00:00

abstract：:Gastroblastoma is a rare gastric epitheliomesenchymal biphasic tumour composed of spindle and epithelial cells, reported by Miettinen et al in a series of three cases in 2009. All those cases arose in stomachs of young adults. Neither the epithelial nor the mesenchymal component displayed sufficient atypia to diagnose...

journal_title：Journal of clinical pathology

authors： Shin DH,Lee JH,Kang HJ,Choi KU,Kim JY,Park DY,Lee CH,Sol MY,Park JH,Kim HY,Montgomery E

更新日期：2010-03-01 00:00:00

abstract：AIMS:The IHC4+C score combines assessment of oestrogen receptor (ER), progesterone receptor (PgR), HER2 and Ki67 with clinicopathological parameters to identify the risk of distant disease recurrence in patients with breast cancer, so, aiding treatment decision-making on adjuvant chemotherapy. Despite low cost and wide...

journal_title：Journal of clinical pathology

authors： Dodson A,Zabaglo L,Yeo B,Miller K,Smith I,Dowsett M

更新日期：2016-02-01 00:00:00

abstract：:In two out of three cases of idiopathic fibrosis of the mediastinum there was also retroperitoneal fibrosis, and in one of them extensive fibrosis of the lungs. One of these, a fit middle-aged man, died suddenly with severe coronary artery stenosis due to fibrosis. The third case was that of a young man with a solitar...

journal_title：Journal of clinical pathology

authors： Light AM

更新日期：1978-01-01 00:00:00

abstract：:The diagnostic value of the Becton Dickinson Radioassay Kit (125I) for the the assay of red cell folate has been investigated. The assay was acceptable with regards to precision but was non-linear with changing packed cell volume. Sensitivity of the assay was satisfactory, with 24 of 25 folate deficient patients givin...

journal_title：Journal of clinical pathology

authors： Bain BJ,Wickramasinghe SN,Broom GN,Litwinczuk RA,Sims J

更新日期：1984-08-01 00:00:00

abstract：AIMS:Personalised breast cancer therapy requires pathological characterisation of tumours. The proliferative index, based on Ki67, is pivotal, but a standard method has not been established. Here we look for an easy and practical way to evaluate Ki67. METHODS:Immunohistochemical staining of estrogen receptors, progest...

journal_title：Journal of clinical pathology

authors： Hida AI,Bando K,Sugita A,Maeda T,Ueda N,Matsukage S,Nakanishi M,Kito K,Miyazaki T,Ohtsuki Y,Oshiro Y,Inoue H,Kawaguchi H,Yamashita N,Aogi K,Moriya T

更新日期：2015-05-01 00:00:00

abstract：:A family with hypobetalipoproteinaemia was studied to examine the Lp(a) lipoprotein, lipoprotein cholesterol, and triglyceride composition of the serum lipids. Lp(a) lipoprotein was measured by immunoassay. Serum lipoproteins were separated by ultracentrifugation. Cholesterol and triglycerides were measured using stan...

journal_title：Journal of clinical pathology

authors： Crook M,Swaminathan R

更新日期：1995-06-01 00:00:00

abstract：BACKGROUND:Accurate assessment of invasive breast cancer grade on needle core biopsy (NCB) is important as it guides treatment. AIM:To assess the agreement between grade of invasive cancer on NCB and excision and determine whether altering the mitotic count score threshold on NCB improves it. METHODS:Pathology slides...

journal_title：Journal of clinical pathology

authors： Dhaliwal CA,Graham C,Loane J

更新日期：2014-12-01 00:00:00

abstract：:A 67 year old woman with rheumatoid arthritis was admitted to hospital in acute renal failure. Her clinical features included increasing dyspnoea and oedema, and a computed tomogram of the abdomen showed a large mass in the retroperitoneum. Twenty six days later, she died, and a post mortem examination was carried out...

journal_title：Journal of clinical pathology

authors： Shimada M,Kojima M,Tani G,Komatsumoto S,Nara M

更新日期：1993-11-01 00:00:00

abstract：:The haematological features of 118 cases of primary myelodysplastic syndromes (PMDS) were reviewed to see how these could be related and classified according to the recent FAB proposals. A majority of the cases were elderly who presented with a macrocytic or normocytic anaemia and reticulocytopenia. Cases of acquired ...

journal_title：Journal of clinical pathology

authors： Juneja SK,Imbert M,Jouault H,Scoazec JY,Sigaux F,Sultan C

更新日期：1983-10-01 00:00:00

abstract：AIMS:Because sentinel lymph node (SLN) biopsy for breast cancer has become well established, one of the challenges now is to determine which patients require a completion axillary dissection following a positive SLN biopsy. METHODS:A prospective database of patients who underwent SLN biopsy for invasive breast cancer ...

journal_title：Journal of clinical pathology

authors： Fleming FJ,Kavanagh D,Crotty TB,Quinn CM,McDermott EW,O'Higgins N,Hill AD

更新日期：2004-01-01 00:00:00

abstract：AIMS:To estimate the expression of substance P in the haematopoietic cells of hypoplastic bone marrow and define its relationship with the course of bone marrow hypoplasia. METHODS:Bone marrow specimens were obtained from 42 children with bone marrow hypoplasia who were hospitalised in the Department of Pediatric Onco...

journal_title：Journal of clinical pathology

authors： Nowicki M,Ostalska-Nowicka D,Konwerska A,Miskowiak B

更新日期：2006-09-01 00:00:00